Vosaroxin

Manufactured by Selleck Chemicals

Sourced in United Kingdom

Vosaroxin is a quinolone derivative that inhibits topoisomerase II, an enzyme essential for DNA replication and cell division. It is used as a laboratory reagent for studying DNA-protein interactions and cellular processes.

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Lab products found in correlation

Etoposide, by Bio-Techne (2 mentions) Ac220, by Selleck Chemicals (2 mentions) Selinexor, by Selleck Chemicals (1 mentions) A 1210477, by Chemietek (1 mentions) Tw 37, by Selleck Chemicals (1 mentions) Pladienolide b, by Santa Cruz Biotechnology (1 mentions) Calyculin a, by Santa Cruz Biotechnology (1 mentions) C2 ceramide, by Santa Cruz Biotechnology (1 mentions)

2 protocols using vosaroxin

Compound Screening in Cancer Research

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Drugs and suppliers used in the study were as follows: 17-AAG, rapamycin, sorafenib and torin1 from LC labs (www.lclabs.com); AC220, JQ1, selinexor, tosedostat, TW-37 and vosaroxin from Selleck (supplied by Stratech UK); ABT-199 from Adooq, www.adooq.com; ABT-737 from Sequoia, Pangbourne, UK; A-1210477 from Chemie Tek, www.chemietek.com; etoposide from Tocris, Bristol, UK; Mylotarg from Wyeth, Pearl River USA; Pladienolide B from Santa Cruz, supplied by Insight, Wembley, UK; TG02 was from Tragara, San Diego, USA. Other drugs and reagents were from Sigma (Poole, Dorset, UK) unless specified.

Grundy M., Seedhouse C., Jones T., Elmi L., Hall M., Graham A., Russell N, & Pallis M. (2018). Predicting effective pro-apoptotic anti-leukaemic drug combinations using co-operative dynamic BH3 profiling. PLoS ONE, 13(1), e0190682.

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Comprehensive Drug Screening Protocol

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Drugs and suppliers used in the study were as follows: 17-AAG, rapamycin, sorafenib, U0126 and torin 1 from LC labs (www.lclabs.com); AC220 and vosaroxin from Selleck (supplied by Stratech UK); etoposide from Tocris; gemtuzumab ozogamicin (GO) was a gift from Wyeth, Pearl River USA. C2 ceramide and Calyculin A were from Santa Cruz Biotechnology, Santa Cruz, CA, USA. Ly294006 was from Millipore, Watford, UK. Other drugs and reagents were from Sigma (Poole, Dorset, UK) unless specified.

Grundy M., Jones T., Elmi L., Hall M., Graham A., Russell N, & Pallis M. (2018). Early changes in rpS6 phosphorylation and BH3 profiling predict response to chemotherapy in AML cells. PLoS ONE, 13(5), e0196805.

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