[11C] PiB-PET scanning was performed at Samsung Medical Center or Asan Medical Center using a Discovery STe PET/CT (computed tomography) scanner (GE Medical Systems, Milwaukee, WI) in three-dimensional (3D) scanning mode with 35 slices at 4.25-mm thickness spanning the entire brain. [11C] PiB was injected into the antecubital vein as a bolus at a mean dose of 420 MBq (i.e., range 259–550 MBq). A CT scan was performed for attenuation correction at 60 min after injection. A 30-min emission static PET scan was initiated. The specific radioactivity of [11C]-PiB at the time of administration was greater than 1500 Ci/mmol for patients, and the radiochemical yield was greater than 35%. The radiochemical purity of the tracer was greater than 95% in all PET studies.
Discovery ste pet ct
Manufactured by GE Healthcare
Sourced in Japan
The Discovery STE PET/CT is a diagnostic imaging system designed for Positron Emission Tomography (PET) and Computed Tomography (CT) scans. It combines the functionality of these two imaging modalities to provide comprehensive medical information for healthcare professionals.
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4 protocols using discovery ste pet ct
1
Amyloid PET Imaging Protocol
2
Standardized 18F-FDG PET-CT Imaging Protocol
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The patients fasted for at least 6 h prior to the 18F-FDG injection and serum glucose level was ensured to be <160 mg/dL in all patients. Patients were given intravenous injection of 296–370 MBq (8–10 mCi) of 18F-FDG. Thereafter, patients were asked to rest in an isolated quiet room for 45–60 min. The scan images were acquired on a dedicated PET-CT scanner (GE Discovery STE PET/CT with 16 slice CT). A contrast-enhanced CT transmission scan was performed first (120 KvP, 200 mAs, 0.8 s/CT rotation) with additional breathhold high-resolution CT for evaluation of lung fields. After transmission scanning, three-dimensional PET images were acquired immediately for 2 min per bed position without changing the patient position. CT-based attenuation correction of the emission images was employed. CT acquisition data were used for attenuation correction of the PET emission data and fusion of attenuation-corrected PET images with the corresponding CT images. PET images were reconstructed by using ordered-subset expectation maximization algorithm, CT attenuation correction, dead time correction, and decay correction to beginning of each scan.
3
18F-FDG-PET/CT Brain Imaging Protocol
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The exclusion criteria for 18F-FDG-PET/CT imaging were as follows: symptomatic status epilepticus, medical instability, uncooperative behavior or poor glycemic control. Patients were intravenously injected with 350 MBq of 18F-FDG following a period of at least 7 h of fasting. Image acquisition (Discovery® ST-E PET/CT, GE Healthcare, Tokyo, Japan) was then performed after 60 min.
The primary objective was to measure the maximum standardized uptake value (SUVmax) of the whole brain, each hemisphere, and the thalamus using three-dimensional volumes of interest (VOIs) based on commercial software (syngo.via®, Siemens, Tokyo, Japan). VOIs were set at 50% of the peak SUV value (Additional file1 : Figure S1).
The primary objective was to measure the maximum standardized uptake value (SUVmax) of the whole brain, each hemisphere, and the thalamus using three-dimensional volumes of interest (VOIs) based on commercial software (syngo.via®, Siemens, Tokyo, Japan). VOIs were set at 50% of the peak SUV value (Additional file
4
18F-FDG-PET Imaging Protocol for Nuclear Medicine
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All subjects underwent an 18F-FDG-PET imaging session, using 3D PET scans, either a General Electric Discovery LS PET/CT or a multi-ring General Electric Discovery STE PET/CT at the Department of Nuclear Medicine, San Raffaele Hospital, Milan, Italy. Patients received an intravenous injection of approximately 270 MBq of 18F-FDG (mean dose 250,60 MBq; SD: 56,41 range 179–351) in rest condition, lying supine in a quiet, dimly-lit room. Image acquisition started approximately 45min after injection, with a scan duration of 15 minutes. In particular, before radiopharmaceutical injection of 18F-FDG, subjects were fasted for at least 6 hours and measured blood glucose level threshold of <120 mg/dL. Image reconstruction followed an ordered subset expectation maximization (OSEM) algorithm. CT was co-registered and used for attenuation correction. Scatter correction was applied with software integrated in our scanner. The protocol has been approved by the San Raffaele Hospital Local Ethical Committee. All the patients gave informed written consent.
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