Thrombomodulin bdca 3

Manufactured by R&D Systems

Sourced in United States

Thrombomodulin/BDCA-3 is a protein that plays a role in the regulation of blood clotting. It is a receptor for thrombin, an enzyme involved in the blood coagulation process. Thrombomodulin/BDCA-3 acts as a cofactor, enhancing the ability of thrombin to activate protein C, which helps to inhibit further blood clot formation.

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Lab products found in correlation

2 protocols using thrombomodulin bdca 3

Crocin and Inflammatory Pathways

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Crocin (purity assay of ≥ 98%) was purchased from Shanghai Yuanye Biological Technology Co., Ltd. Methylthiazolyldiphenyl-tetrazolium bromide (MTT), LPS, 4,6-diamidino-2-phenylindole dihydrochloride (DAPI), fluorescein isothiocyanate (FITC)-albumin, and dimethyl-sulfoxide (DMSO) were obtained from Sigma-Aldrich. Rabbit monoclonal antibody to HMGB1 (ab79823), NF-κB p65 (ab32536), IκBα (ab32518), p-IκBα (ab133462), JNK (ab112501), ERK (ab184699), p38 (ab170099), p-ERK (ab201015), p-JNK (ab4821), p-p38 (ab47363), LaminB1 (ab133741), MMP-9 (ab38898), HPA (ab85543), SDC-4 (ab24511), Ly6g (ab25377), β-actin (ab8224), GAPDH (ab181602), MMP-9 inhibitor (MMP-9 inhib, ab142180), and FITC (ab25539) were acquired from Abcam Trading Company Ltd. Mouse polyclonal antibody to cathepsin L (CTL) was purchased from Santa Cruz Biotechnology. Mouse polyclonal antibody to HS was purchased from AMS Biotechnology (Switzerland, MA). Thrombomodulin/BDCA-3 was obtained from R&D Systems (USA). HRP-conjugated goat anti-rabbit IgG, goat anti-rabbit IgG/Alexa Fluor 594, and rabbit anti-goat IgG/Alexa Fluor were purchased from Beijing Biosynthesis Biotechnology Co., Ltd. Cathepsin L inhibitor (CTL inhib, CAS 167498-29-5) was obtained from Santa Cruz Biotechnology.

Zhang D., Qi B.Y., Zhu W.W., Huang X, & Wang X.Z. (2020). Crocin alleviates lipopolysaccharide-induced acute respiratory distress syndrome by protecting against glycocalyx damage and suppressing inflammatory signaling pathways. Inflammation Research, 69(3), 267-278.

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Molecular Probes for Cell Surface Receptors

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Nef was purchased from Shanghai Ziqi Biology Technology Co., Ltd. (Shanghai, China), with purity of 99.16%. Mouse polyclonal to heparan sulfate antibody was purchased from AMS Biotechnology (Europe) (Switzerland, MA). Rabbit monoclonal to Syndecan-1 was purchased from Abcam (Cambridge, USA). Thrombomodulin /BDCA-3 was purchased from R&D Systems (Minnesota, USA). Fluorescein isothiocyanate (FITC)-conjugated anti-goat IgG and rhodamine-conjugated anti-mouse IgG were purchased from Zhongshan Golden Bridge Biotechnology (Beijing, China).

Liu X.Y., Xu H.X., Li J.K., Zhang D., Ma X.H., Huang L.N., Lü J.H, & Wang X.Z. (2018). Neferine Protects Endothelial Glycocalyx via Mitochondrial ROS in Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome. Frontiers in Physiology, 9, 102.

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