Zetasizer nano particle analyzer

Manufactured by Malvern Panalytical

Sourced in United Kingdom

The Zetasizer Nano Particle Analyzer is a dynamic light scattering (DLS) instrument used to measure the size and zeta potential of particles in a sample. It can determine the size distribution of particles ranging from 0.3 nanometers to 10 micrometers. The Zetasizer Nano also measures the zeta potential of particles, which is an indicator of the stability of colloidal dispersions.

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Lab products found in correlation

1260 infinity, by Agilent Technologies (2 mentions) Nicolet 5700, by Thermo Fisher Scientific (1 mentions) Newborn bovine serum, by Zhejiang Tianhang Biotechnology (1 mentions) Diamonsil c18, by Dikma Technologies (1 mentions)

Close spelling variants of this product

Zetasizer Nano ZS90 Particle Analyzer Zetasizer Nano ZS particle size analyzer Zetasizer Nano S particle size analyzer Zetasizer Nano ZS 90 particle size analyzer Zetasizer Nano ZS particle analyzer Zetasizer Nano analyzer Zetasizer Nano Zetasizer

9 protocols using zetasizer nano particle analyzer

Comprehensive Characterization of Functionalized Mesoporous Silica Nanocomposites

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The size and morphological structure
of samples were examined under
TEM (JEOL JEM 2100 TEM electron microscope). The size distribution
and surface charge of functionalized mesoporous silica nanocomposites
in a suspension were measured on a Zeta-sizer nanoparticle analyzer
(Malvern). The stability of PMS nanocomposites in 10% mouse serum
in DMEM (v/v) or 0.01 M PBS (pH 7.4) at 37 °C for 48 h was tested
by dynamic light scattering (DLS). The surface analysis was employed
by N₂ adsorption isotherms at 77 K (Micromeritics ASAP2020
absorptiometer). The particle surface areas were assessed by the BET
(Brunauer–Emmett–Teller) method and Barrett–Joyner–Halenda
(BJH) method used to calculate the pore size distributions of particles.
FTIR spectroscopy was used to investigate the functional groups at
range of 500–4000 cm^–1 in functionalized
MSNs (Thermo Scientific NICOLET 5700).

Murugan C., Venkatesan S, & Kannan S. (2017). Cancer Therapeutic Proficiency of Dual-Targeted Mesoporous Silica Nanocomposite Endorses Combination Drug Delivery. ACS Omega, 2(11), 7959-7975.

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Nanoliposome Sizing and Characterization

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The particle size and polydispersity of the solution were determined using Zetasizer Nano Particle Analyzer (model 3600, Malvern Instruments, Malvern, UK). The nanoliposomes were measured at an angle of 90° and laser light irradiation at 657 nm at 25 °C was used.

Moghadaszadeh M., Khayyati M., Spotin A., Norouzi R., Pagheh A.S., Oliveira S.M., Pereira M.D, & Ahmadpour E. (2021). Scolicidal and Apoptotic Activities of 5-hydroxy-1, 4-naphthoquinone as a Potent Agent against Echinococcus granulosus Protoscoleces. Pharmaceuticals, 14(7), 623.

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Characterizing Biomolecule-Surfactant Complexes

Cited 2 times

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The determination of hydrodynamic diameter (D_H = 2R_H, nm) and zeta potential of ONu and DNA molecules, as well as their complexes with surfactants, was carried out on a ZetaSizer Nano particle analyzer (Malvern Instruments Ltd., Worcestershire, UK) [49 (link),50 (link),51 (link)]. The hydrodynamic radius of the particles (R_H) was calculated based on the Stokes–Einstein Equation (1) [52 (link),53 (link),54 (link)]:
where k is the Boltzmann’s constant, T is the absolute temperature, η is the solvent’s viscosity, and R_H is the hydrodynamic radius.
The electrophoretic mobility of the samples was converted to zeta potential using the Smoluchowski Equation (2):
where ζ is the zeta potential, η is the dynamic viscosity of the solution, μ is the mobility of the particle, and ε is the dielectric constant.
The experiment was carried out at an initial concentration of ONu equal to 500 µM and DNA equal to 10 µM and at sequential titration of these systems with surfactant solutions to obtain a certain molar ratio of N/P (nitrogen/phosphorus − r).

Kuznetsova D.A., Kuznetsov D.M., Vasileva L.A., Amerhanova S.K., Valeeva D.N., Salakhieva D.V., Nikolaeva V.A., Nizameev I.R., Islamov D.R., Usachev K.S., Voloshina A.D, & Zakharova L.Y. (2022). Complexation of Oligo- and Polynucleotides with Methoxyphenyl-Functionalized Imidazolium Surfactants. Pharmaceutics, 14(12), 2685.

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Characterization and Evaluation of SHK@HA-MPDA Nanoparticles

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The size, polydispersity (PDI), and zeta potential of SHK@HA-MPDA nanoparticles were measured by a Zeta Sizer Nanoparticle Analyzer (Malvern Panalytical, Malvern, UK). The morphological observation of SHK@HA-MPDA was carried out by transmission electron microscopy (TEM). The drug encapsulation efficiency (EE%) and drug-loading capacity (DL%) of SHK@HA-MPDA were determined by high-performance liquid chromatography (HPLC) (1260 Infinity, Agilent Technologies, Santa Clara, USA) equipped with Agilent-C18 (5 μm, 250 mm × 4.6 mm). The chromatographic conditions for SHK determination were listed as follows: mobile phase composed of methanol (90%) and phosphoric acid (0.01%) aqueous solution, flow rate of 1 mL/min, and detection wavelength of 516 nm. The in vitro drug release was evaluated by a dialysis method using a dialysis membrane (MWCO 8,000–14,000 Da) in PBS (pH 5.0) containing 0.5% (w/v) SDS with 150 rpm/min shaking at 37 °C. The released drugs were quantified by HPLC as described above. The serum stability of SHK@HA-MPDA was evaluated by suspending them in PBS containing 10% new-born bovine serum (Zhejiang Tianhang Biotechnology Co., Ltd, Hangzhou, China) with a general shaking at 150 rpm at 37 °C. The size of particles at a specified time was measured by a Zeta Sizer Nanoparticle Analyzer.

Long L., Xiong W., Lin F., Hou J., Chen G., Peng T., He Y., Wang R., Xu Q, & Huang Y. (2023). Regulating lactate-related immunometabolism and EMT reversal for colorectal cancer liver metastases using shikonin targeted delivery. Journal of Experimental & Clinical Cancer Research : CR, 42, 117.

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Emulsion Droplet Size Determination

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The emulsion was prepared by dilution with distilled water in a 500-ml beaker and gentle agitation using a glass rod. The emulsion droplet diameter was subsequently determined by dynamic light scattering using a Zetasizer Nano Particle Analyzer (Malvern Instruments, UK). A helium–neon laser (4 mW) was operated at 633 nm with the scattering angle being fixed at 173° and the temperature being maintained at 25 °C. All the measurements were performed in triplicate (Li et al., 2010 ).

Anwar S.H., Hasni D., Rohaya S., Antasari M, & Winarti C. (2020). The role of breadfruit OSA starch and surfactant in stabilizing high-oil-load emulsions using high-pressure homogenization and low-frequency ultrasonication. Heliyon, 6(7), e04341.

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Time-Dependent Particle Size Analysis

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GEM@ZIF-67-HA NPs were diluted to a concentration of
0.1 mg/mL using PBS (pH = 7.4) buffer and 5% FBS-DMEM medium, respectively.
The particle size was measured at 1, 2, 3, 4, 5, 6, and 7 days using
a Malvern Zetasizer nanoparticle analyzer. Three readings were taken
for each sample, and the average value was recorded as the result.

Long C., Peng H., Yang W., Wang M., Luo B., Hao J., Dong Y, & Zuo W. (2024). Targeted Delivery of Gemcitabine for Precision Therapy of Cholangiocarcinoma Using Hyaluronic Acid-Modified Metal–Organic Framework Nanoparticles. ACS Omega, 9(10), 11998-12005.

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Liposome Formulation Characterization

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The modification efficiency of LF on LF-Lipo was determined by SDS-PAGE and quantitatively analyzed by ImageJ software (National Institutes of Health, Bethesda, MD, USA). The particle size, polydisperse index (PDI), and zeta potential of Lipo and LF-Lipo were measured by a Zeta Sizer Nanoparticle Analyzer (Malvern Panalytical, Malvern, UK). The morphological observation of the liposomes was performed using transmission electron microscopy (TEM). The drug encapsulation efficiency (EE%) and drug-loading capacity (DL%) of the liposomes were determined by high-performance liquid chromatography (HPLC) (1260 Infinity, Agilent technologies, Santa Clara, CA, USA) equipped with Diamonsil-C18 (5 μm, 250 mm × 4.6 mm, Dikma, Beijing, China). The chromatographic conditions are listed in Supporting Information Tables S1 and S2.

He Y., Fang Y., Zhang M., Zhao Y., Tu B., Shi M., Muhitdinov B., Asrorov A., Xu Q, & Huang Y. (2021). Remodeling “cold” tumor immune microenvironment via epigenetic-based therapy using targeted liposomes with in situ formed albumin corona. Acta Pharmaceutica Sinica. B, 12(4), 2057-2073.

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Particle Size and Swelling Dynamics in Enzymatic Hemicellulose Hydrolysis

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The dissolution of solid substrate particles and the swelling of the polymer in the hydrolyzing medium in the time course of enzymatic hydrolysis of hemicellulose are studied by measuring the average particle size and the particle size distribution by Dynamic Light Scattering (DLS) technique using zetasizer nanoparticle analyzer (Malvern, UK) with laser at a wavelength of 633 nm and at a constant temperature of 25 °C. A sample of 1.5 ml is taken, and the scattering intensity of the laser is measured at 90° angle with the counting time of 80s for each sample. The data collection is performed by DTS (Nano) software.

Dutta S.K, & Chakraborty S. (2016). Pore-scale dynamics of enzyme adsorption, swelling and reactive dissolution determine sugar yield in hemicellulose hydrolysis for biofuel production. Scientific Reports, 6, 38173.

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Synthesis of Citrate-Stabilized Gold Nanoparticles

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Au NPs were prepared by citrate-mediated reduction of HAuCl4. Briefly, 1 mL of 1% (w/v) hydrogen tetrachloroaurate solution was added to 99 mL of water. The solution was brought to boil and stirred vigorously. Then, 4 mL of 1% (w/v) sodium citrate was added to the boiling solution quickly. The solution was continuously stirred until the solution color turned to wine red. After another 5 min of stirring, the heat source was removed and the solution was cooled down to room temperature. The average size of gold nanoparticles identified by a Zetasizer nanoparticle analyzer (Malvern Instruments, UK) was about 16 ± 1 nm. In order to remove free sodium citrate in the solution, the Au NPs were isolated by centrifugation (12000 rpm for 20 min) and resuspended in ultrapure water.
The centrifugation-resuspension-recentrifugation cycle was repeated 2 times. The red oily precipitate was resuspended in ultrapure water, and was one-tenth of its original volume.
The concentration of the Au NPs was calculated to be 7.36 nmol dm -3 according to the Lambert-Beer law.

Kong Y., Shen J, & Fan A. (2017). Colorimetric Method for the Detection of Mercury Ions Based on Gold Nanoparticles and Mercaptophenyl Boronic Acid. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 33(8).

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