Tomohd

Manufactured by Accuray

Sourced in United States

The TomoHD is a radiation therapy system designed for precise and accurate treatment of cancer. It utilizes advanced imaging and treatment delivery technologies to target tumors while minimizing exposure to healthy tissue.

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Lab products found in correlation

Tomotherapy planning station, by Accuray (1 mentions) Somatom sensation, by Siemens (1 mentions) Mr750, by GE Healthcare (1 mentions)

4 protocols using tomohd

Definitive RT for NPCa patients

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With the approval from the institutional review board (IRB SMC 2020-02-134-001), 10 consecutive NPCa patients, who underwent definitive RT between October 2017 and January 2018 at the authors’ department with helical tomotherapy (HT; TomoHD, Accuray, Sunnyvale, CA), were included in this study (Table 1).

Ju S.G., Ahn Y.C., Kim Y.B., Park S.G., Choi Y.M., Na C.H., Hong C.S., Oh D., Kwon D.Y., Kim C.C, & Kim D.H. (2020). Development of a Tongue Immobilization Device Using a 3D Printer for Intensity Modulated Radiation Therapy of Nasopharyngeal Cancer Patients. Cancer Research and Treatment : Official Journal of Korean Cancer Association, 53(1), 45-54.

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Comparison of VMAT and Helical Tomotherapy

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For VMAT, treatment planning was performed by Pinnacle TPS using the SmartArc optimization algorithm. Treatment machine, dose calculation algorithm, dose grid size and PTV margin setting were the same as in the aforementioned 3DCRT conditions. Beam energy was 10 MV, and one full arc (181 to 179° clockwise) with a collimator angle of 15° was used. All patients received a dose covering 50% volume (D50%) prescription of 76 Gy for PTV in 38 Fr. The dose constraints of the rectum were D2% < 74.4 Gy, D10% < 66.5 Gy and D50% < 20.0 Gy. The dose constraints of the bladder were D15% < 73 Gy, D25% < 70 Gy, D35% < 67 Gy and D50% < 57 Gy.
For HT, treatment planning was performed by Tomotherapy Planning Station (Accuray, Sunnyvale, CA) and TomoHD (Accuray, Sunnyvale, CA) was used as the treatment machine. The plans for HT were created with a dynamic jaw mode using a jaw size of 2.51 cm and pitch size of 0.287 cm in all cases. The convolutional/superposition algorithm with the fine dose grid was used as the dose calculation algorithm. The dose prescription and dose constraints were the same as those in VMAT.

Saito M., Suzuki T., Sugama Y., Marino K., Sano N., Komiyama T., Aoki S., Maehata Y., Yoshizawa K., Ashizawa K., Suzuki H., Ueda K., Miyasaka Y., Araya M., Takahashi H, & Onishi H. (2020). Comparison of rectal dose reduction by a hydrogel spacer among 3D conformal radiotherapy, volumetric-modulated arc therapy, helical tomotherapy, CyberKnife and proton therapy. Journal of Radiation Research, 61(3), 487-493.

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Tomotherapy Planning for Cancer Radiotherapy

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The HT plans were generated using a tomotherapy planning station with a 6-MV X-ray and performed on the Tomo HD (Accuray Inc., Madison, USA). The parameters for beamlet calculation included a field width of 2.5 cm, a pitch value of 0.287, a modulation factor of 3, and a normal dose calculation grid.

Lu S., Fan H., Hu X., Li X., Kuang Y., Yu D, & Yang S. (2021). Dosimetric Comparison of Helical Tomotherapy, Volume-Modulated Arc Therapy, and Fixed-Field Intensity-Modulated Radiation Therapy in Locally Advanced Nasopharyngeal Carcinoma. Frontiers in Oncology, 11, 764946.

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Multimodal Imaging for SPR Assessment

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The full multimodal imaging pipeline for determining SPR is depicted in Figure 3. Both MRI datasets were acquired on a 3 Tesla scanner (MR750; GE Healthcare, Milwaukee, WI) using 3D acquisition and 2mm slice thickness, with all images acquired using a transmit/receive quadrature birdcage-type head coil. This type of head coil allowed for a highly homogenous signal acquisition²¹ not requiring specific compensation for B₁ inhomogeneities. The Dixon water-only image was acquired using flip angle of 1°, TR of 3.77ms, and TE of 2.32ms and 1.12ms for the in-phase and out-of-phase images, respectively. The ZTE scan was acquired using flip angle of 0.6°, TR of 1.34ms, and TE of 0.016ms. kVCT images were acquired on a Siemens scanner (SOMATOM Sensation; Siemens, Erlangen, Germany) using 120kVp energy and 1mm slice thickness. MVCT images were acquired on a TomoTherapy system (TomoHD; Accuray, Sunnyvale, CA) using the 3.5MV energy MVCT beam with fine pitch and 1mm slice thickness reconstruction.

Scholey J.E., Chandramohan D., Naren T., Liu W., Larson P.E, & Sudhyadhom A. (2020). Technical note: A methodology for improved accuracy in stopping power estimation using MRI and CT. Medical physics, 48(1), 342-353.

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