Rx daytona chemistry analyzer

Manufactured by Randox

Sourced in United Kingdom

The RX Daytona is a compact, fully automated chemistry analyzer designed for routine clinical chemistry testing. It utilizes photometric detection to perform a wide range of assays, including tests for enzymes, proteins, lipids, and other analytes. The RX Daytona is capable of handling a variety of sample types and provides accurate and reliable results to support clinical decision-making.

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Lab products found in correlation

Modular autoanalyzer, by Roche (1 mentions) G7 hplc analyzer, by Tosoh (1 mentions)

4 protocols using rx daytona chemistry analyzer

Comprehensive Characterization of Glomerular Diseases

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Demographic and clinical characteristics collected at study enrollment included age, sex, race, ethnicity, glomerular disease subtype, disease duration, medication use at or before enrollment, and treatment responsiveness (ie, steroid responsive, steroid‐resistant, or multidrug resistant, as noted in medical records by treating providers).
Other variables of interest included estimated glomerular filtration rate (eGFR), serum albumin, and urine protein‐to‐creatinine ratio (UPCR). The central CureGN laboratory utilized a Randox RX Daytona chemistry analyzer to measure serum and urine creatinine using the Jaffe method, and urine protein with a colorimetric method. When central measurements were not available (74% serum creatinine, 80% UPCR), serum creatinine and UPCR measurements performed in local laboratories within 60 days before and after enrollment were extracted from clinical records. Estimated GFR was calculated using the modified Schwartz formula.16

Ashoor I.F., Mansfield S.A., O'Shaughnessy M.M., Parekh R.S., Zee J., Vasylyeva T.L., Kogon A.J., Sethna C.B., Glenn D.A., Chishti A.S., Weaver D.J., Helmuth M.E., Fernandez H.E, & Rheault M.N. (2019). Prevalence of Cardiovascular Disease Risk Factors in Childhood Glomerular Diseases. Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 8(14), e012143.

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Biochemical Assays for Metabolic Markers

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Plasma glucose was measured using the hexokinase method on a Randox RX Daytona Chemistry Analyzer. Enzymatic colorimetric assays were used to measure triglycerides, total cholesterol and high-density lipoprotein cholesterol using the Roche Modular Auto Analyzer, while low-density lipoprotein cholesterol was calculated using direct methods. Coefficients of variation calculated from running 40 separate samples in duplicate were 3.0% for glucose, 3.1% for cholesterol, 3.1% for triglycerides and 3.4% for insulin.

Chivese T., Norris S.A, & Levitt N.S. (2019). High prevalence of cardiovascular risk factors and insulin resistance 6 years after hyperglycemia first detected in pregnancy in Cape Town, South Africa. BMJ Open Diabetes Research & Care, 7(1), e000740.

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Metabolic and Hormonal Biomarker Profiling

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At ~08:00 and after an overnight (10–12 hours) fast, blood samples were taken for the measurement of fasting insulin, glucose, liver enzymes (alanine transaminase (ALT), aspartate transaminase (AST), and gamma-glutamyl transferase (GGT)), gonadotrophins (luteinizing hormone (LH), follicle-stimulating hormone (FSH)), sex hormones (testosterone, estrogen, androstenedione, and dehydroepiandrosterone (DHEA)), lipids (total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG)), and glucocorticoids (cortisol and cortisone).
FSH and LH were measured with the ARCHITECT Chemiluminescent Microparticle Immunoassay assay (Abbott Laboratories). Sex steroids and glucocorticoids were measured by ultra-high performance liquid chromatography–tandem mass spectrometry.22 (link) Serum insulin and lipid concentrations were measured with Immulite 1000 Immunoassay System (Siemens Chemiluminescent Healthcare GmbH, Henkestr, Germany) and glucose concentrations with a Randox RX Daytona Chemistry Analyzer (Randox Laboratories, London, UK), respectively. TC, TG, and HDL-C were measured directly from the Immulite 1000 Immunoassay System (Siemens Chemiluminescent Healthcare GmbH). LDL-C was calculated with the Friedewald equation.23 (link)

Masango B., Goedecke J.H., Ramsay M., Storbeck K.H., Micklesfield L.K, & Chikowore T. (2024). Postprandial glucose variability and clusters of sex hormones, liver enzymes, and cardiometabolic factors in a South African cohort of African ancestry. BMJ Open Diabetes Research & Care, 12(2), e003927.

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Oral Glucose Tolerance Test Protocol

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An oral glucose load of 1.75 g per kg of body weight was administered up to a maximum of 75 g (Glucola, Fisherbrand, Waltham, MA, USA). Serial blood draws were performed at 30 min intervals for two hours and glucose homeostasis assays were conducted by the Michigan Diabetes Research Center (Ann Arbor, MI, USA). A Randox rX Daytona Chemistry Analyzer (Randox Laboratories Limited, Crumlin, UK) measured lipids (total cholesterol with the cholesterol enzymatic end point method, triglycerides with the GPO-PAP method, and HDL and LDL with the two step-direct method) and glucose with the glucose hexokinase method. A double-antibody radioimmunoassay was used to measure insulin. Both glucose and insulin were measured from plasma. Derived summary variables included FPG (0 min glucose), 2hrPG (120 min glucose), and dysglycemia, defined as having FPG > 100 mg/dL or 2hrPG > 140 mg/dL. HbA1c was quantified with a Tosoh G7 HPLC Analyzer (Tosoh Biosciences Inc., San Francisco, CA, USA).

Renier T.J., Mai H.J., Zheng Z., Vajravelu M.E., Hirschfeld E., Gilbert-Diamond D., Lee J.M, & Meijer J.L. (2024). Utilizing the Glucose and Insulin Response Shape of an Oral Glucose Tolerance Test to Predict Dysglycemia in Children with Overweight and Obesity, Ages 8–18 Years. Diabetology, 5(1), 96-109.

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