1 2 dichloroethane

Sulfuric acid (H₂SO₄, AR) and hydrochloric acid (HCl, AR) were purchased from Zhitang Chemical Company. Tetramethylammonium chloride (TMACl, ≥98%, TCI), lithium tetrakis(pentafluorophenyl)borate ethyl etherate (LiTPFB, Aldrich), potassium tetrakis(4-chlorophenyl)-borate (KTPBCl, ≥98%, Aldrich), bis(triphenylphosphoranylidene)-ammonium chloride (BTPPACl, ≥98%, Aldrich), bis(pentamethylcyclopentadienyl)iron (DMFc, ≥97%, Aldrich), tetraphenylporphyrin (H₂TPP, ≥98%, TCI), tetrathiafulvalene (TTF, ≥97%, Aldrich) were used as received without further purification. 1,2-Dichloroethane (DCE, ≥99%, Sinopharm Chemical Reagent Co.) was washed with triply distilled water before use. Bis-(triphenylphosphoranylidene)-ammonium tetrakis(4-chlorophenyl) borate (BTPPATPBCl) was synthesized by metathesis of equimolar solutions of BTPPACl and KTPBCl. The salts were recrystallized from acetone and then dried in an oven at 95 °C for 24 h. Tetramethylammonium tetrakis(pentafluorophenyl)borate (TMATPFB) was synthesized by the same method. All aqueous solutions were prepared from triply distilled water.

Divinylbenzene (DVB, 80 wt.%), methylacrylate (MA, >99%), benzoyl peroxide, and TC were obtained from J&K Chemical Co., Ltd., China. Tetraethylenepentamine, anhydrous ferric chloride, 1,2-dichloroethane, sodium chloride, hydrochloric acid, sodium hydroxide, and cupric nitrate trihydrate were all analytical reagents and purchased from Sinopharm Chemical Reagent Co., Ltd (China). DVB and MA were passed through a strong base anion exchange resin column to remove the inhibitors prior to use.

The 1,2-dichloroethane was purchased from Sinopharm Chemical Reagent Co., Ltd. (Ningbo, China). The BCA protein assay kit, multicolor prestained protein marker, and ECL plus kit were obtained from Thermo Fisher Scientific (Waltham, MA, USA). Antibodies for claudin 5 and occludin were obtained from Abcam (Cambridge, UK). Antibodies against glial fibrillary acidic protein (GFAP) and soluble calcium-binding protein 100B (S100B) were the products of ABMART (Shanghai, China). Antibodies against ionized calcium-binding adapter molecule1 (Iba-1), interleukin 6 (IL-6), cluster of differentiation 11b (CD11b), and nuclear factor-κB (NF-κB, p-p65) were obtained from ImmunoWay (Texas, USA). Antibodies for tumor necrosis factor α (TNF-α) and β-actin were purchased from Elabscience (Wuhan, China). Antibodies for arginase-1 (Arg-1), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), MMP-9, inducible nitric oxide synthase (iNOS), Toll-like receptor 4 (TLR4), and MyD88 were obtained from Wanleibio (Shenyang, China). RIPA lysis buffer and the PAGE Gel Kit were obtained from EpiZyme (Shanghai, China). Minocycline was purchased from Solarbio (Beijing, China). DL-Fluorocitric acid barium salt and melatonin were obtained from Sigma-Aldrich (St. Louis, MO, USA).

Divinylbenzene (DVB) (80 wt%), glycidyl methacrylate (GMA) (97 wt%), CPX, and HA were obtained from J&K Chemical Co. Ltd. (China). Benzoperoxide, ferric chloride, ferric chloride hexahydrate, ferrous chloride tetrahydrate, acetone, aqueous ammonia (25 wt%), oleic acid, methanol, ethanol, toluene, gelatin, trisodium phosphate, disodium hydrogen phosphate, sodium hydroxide, sodium chloride, hydrochloric acid, and 1,2-dichloroethane were of analytical grade and purchased from Sinopharm Chemical Reagent Co. Ltd. (China). Dimethylamine was produced by Shanghai Chemical Reagent Corp. (China). Five magnetic multifunctional resins designated as GMA10 to GMA90 were obtained through a sequence of polymerization, amination, and post-crosslinking reactions. Detailed procedures for the preparation of resins are described in the Supplementary Information.