Mek162

Manufactured by CSNpharm

Sourced in United States

MEK162 is a laboratory equipment product. It is a small molecule that inhibits the mitogen-activated protein kinase kinase (MEK) enzyme. MEK162 is used for research purposes in cellular and biochemical assays.

Automatically generated - may contain errors

Lab products found in correlation

Cell cycle and apoptosis analysis kit, by Beyotime (1 mentions) Polyvinylidene fluoride (pvdf), by Merck Group (1 mentions) Ham s f12k kaighn s medium f12k, by Thermo Fisher Scientific (1 mentions) Annexin 5 fitc apoptosis detection kit c1062m, by Beyotime (1 mentions) Fast silver stain kit, by Beyotime (1 mentions) Cell counting kit 8 cck 8, by Targetmol (1 mentions) Super ecl detection reagent, by Yeasen (1 mentions)

2 protocols using mek162

Cucurbitacin B and MEK162 Protocol

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Cucurbitacin B (98%) was purchased from the Nanjing SenBeiJia Biological Technology Co., Ltd. (SBJ-I0498, Jiangsu, China). MEK162 was purchased from the CSNpharm (CSN16001, Chicago, USA). Fetal bovine serum (FBS, 42F6590K), RPMI-1640 medium HEPES (1640H, 22400089) and Ham's F12K (Kaighn's) medium (F12K, 21127022) were from Gibco (NY, USA). Phosphate buffer solution (PBS), phenylmethanesulfonyl fluoride (PMSF, 20104ES03), RIPA lysis buffer (20114ES60), penicillin–streptomycin (60162ES76), Super ECL Detection Reagent (36208ES60) were from Yeasen (Shanghai, China). Serum-free cell freezing medium was from NCM Biotech Co., Ltd. (C40050, Suzhou, China). Cell counting kit-8 (CCK-8) was procured from TargetMol (C0005, Boston, USA). Cell Cycle and Apoptosis Analysis Kit (C1052), Annexin V-FITC Apoptosis Detection Kit (C1062M) and Fast Silver Stain Kit (P0017S) were procured from Beyotime Biotechnology (Jiangsu, China). Multicolor protein markers were from Biorad (161-0394, CA, USA) and Yeasen (20352ES76, Shanghai, China). Polyvinylidene fluoride (PVDF) was from Merck Millipore (IPVH00010, Darmstadt, Germany).

Wei J., Chen X., Li Y., Li R., Bao K., Liao L., Xie Y., Yang T., Zhu J., Mao F., Ni S., Jia R., Xu X, & Li J. (2022). Cucurbitacin B-induced G2/M cell cycle arrest of conjunctival melanoma cells mediated by GRP78–FOXM1–KIF20A pathway. Acta Pharmaceutica Sinica. B, 12(10), 3861-3876.

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Chemical Reagents for Cell Culture

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Fangchinoline (98%) was from Chengdu DeSiTe Biological Technology Co., Ltd (DF0005, Chengdu, China). Cepharanthine, berbamine hydrochloride and tetrandrine (98%) were from Bidepharm. MEK162 was from CSNpharm (CSN16001, Chicago, USA). Dulbecco’s modified Eagle medium (DMEM) and phosphate buffer solution (PBS) were from Hyclone. Fetal bovine serum (FBS, 42F6590K), RPMI-1640 medium HEPES (1640H, 22400089) and Ham’s F12K (Kaighn’s) medium (F12K, 21127022) were from Gibco (Grand Island, NY, USA). Multicolour protein markers were from Absin Bioscience, Inc. (abs923, Shanghai, China) and Yeasen (20352ES76, Shanghai, China).

Bao K., Li Y., Wei J., Li R., Yang J., Shi J., Li B., Zhu J., Mao F., Jia R, & Li J. (2021). Fangchinoline suppresses conjunctival melanoma by directly binding FUBP2 and inhibiting the homologous recombination pathway. Cell Death & Disease, 12(4), 380.

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