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2 3 dimercapto 1 propanol

Manufactured by Tokyo Chemical Industry
Sourced in China

2,3-dimercapto-1-propanol is a chemical compound with the formula C3H8OS2. It is a clear, viscous liquid with a characteristic odor. The compound contains two sulfhydryl (thiol) functional groups, which give it chelating properties.

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2 protocols using 2 3 dimercapto 1 propanol

1

In Vivo Evaluation of ATO and 2,3-Dimercapto-1-Propanol for Pancreatic Cancer

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Five-week-old female athymic nude mice were purchased from Shanghai SLAC Laboratory Animal Co., Ltd. (Shanghai, China) and maintained under specific pathogen-free conditions. The human pancreatic cancer cell line SW 1900 was obtained from the Cell Bank of the Chinese Academy of Science (Shanghai, China). RPMI medium and fetal bovine serum (FBS) were supplied by Gibco Invitrogen (Carlsbad, CA, USA), and cells were maintained in RPMI medium supplemented with 10% FBS. An ATO solution containing 0.9% sodium chloride was provided by Harbin Yida Pharmaceutical Co., Ltd. (China; Lot. 20190102) and 2,3-dimercapto-1-propanol was supplied by Tokyo Chemical Industry Co., Ltd. (Japan; Lot. WG5MB-AT) and stored in anhydrous alcohol. Other reagents were obtained from Sigma-Aldrich (St. Louis, MO, USA) unless otherwise specified. Protocols for animal experiments were approved by the Animal Experimental Ethics Committee of the Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University (HKDL2018329), in compliance with the National Institutes of Health guidelines for the care and use of laboratory animals.
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2

Xenograft model of pancreatic cancer

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Female athymic nude mice were purchased from Shanghai SLAC Laboratory Animal Co., Ltd. (Shanghai, China) and maintained under speci c pathogen-free (SPF) conditions. The human pancreatic cancer cell line used in this study, SW 1900, was obtained from the Cell Bank of the Chinese Academy of Science (Shanghai, China). Both RPMI medium and fetal bovine serum (FBS) were supplied by Gibco Invitrogen (Carlsbad, CA, USA), and cells were maintained in RPMI medium supplemented with 10% FBS. An ATO solution containing 0.9% sodium chloride was provided by Harbin Yida Pharmaceutical Co., Ltd.
(Lot.20190102); 2,3-dimercapto-1-propanol was supplied by Tokyo Chemical Industry Co., Ltd.
(Lot.WG5MB-AT) and stored in anhydrous alcohol. Other reagents were obtained from Sigma-Aldrich unless otherwise speci ed. Protocols for animal experiments were approved by the Animal Experimental Ethic Committee of the Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University.
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