Organic solvents used

sn-Glycero-3-phosphocholine (GPC) in the enantiomerically pure form was purchased from Bachem and converted to the cadmium chloride complex (GPC × CdCl₂) using the method described earlier [22 ]. Racemic acids: 3,7-dimethyl-3-vinyloct-6-enoic acid (1), (E)-3,7,11-trimethyl-3-vinyldodeca-6,10-dienoic acid (2), 2-(2-butylidene-1,3,3-trimethylcyclohexyl)-acetic acid (3) were obtained according to the procedure described before [23 ,24 ]. Organic solvents used in HPLC were purchased from Merck. Phospholipase A₂ (Lecitase 10 L; 10,000 LEU/mL) was a gift from Novozymes.

Fluoxetine hydrochloride, norfluoxetine (NFLX) and formic acid were purchased from Sigma‒Aldrich (St. Louis, MO, United States). Twenty-seven natural products were obtained from Shanghai Chuangsai Technology Co., Ltd. (Shanghai, China). Paroxetine hydrochloride, as an internal standard (IS), was purchased from Toronto Research Chemicals, Inc. (Toronto, ON, Canada). sf21 insect microsomes expressing wild-type and variant CYP2D6, cytochrome b5 and reductase were obtained from Beijing Hospital (Beijing, China). NADPH was obtained from Roche Pharmaceuticals Ltd. (Basel, Switzerland), and the NADPH regeneration system was obtained from Promega (Madison, WI, United States). Rat liver microsomes (RLMs) were obtained from Corning Life Sciences Co., Ltd. The organic solvents used were purchased from Merck (Darmstadt, Germany).