All experiments involving animals were performed in accordance with the animal protocol approved by the Institutional Animal Care and Use Committee at the Institute of Zoology, Chinese Academy of Sciences. Mice were housed in groups of 3~5 animals under a 12 h light/12 h dark cycle, and were fed ad libitum on a standard mouse diet. The miR-137f/f mice were generated as previously described [10 (link)]. The Emx1-Cre transgenic mice were bought from Jackson Laboratory (Stock No. 005628). The miR-137 conditional knockout mice were generated by breeding miR-137f/f mice with Emx1-Cre transgenic mice, as described previously [19 (link)].
Emx1 cre transgenic mice
Manufactured by Jackson ImmunoResearch
Sourced in United States
The Emx1-Cre transgenic mice express the Cre recombinase enzyme under the control of the Emx1 promoter, which is active in the dorsal telencephalon during embryonic development. This allows for the specific targeting and manipulation of gene expression in the cerebral cortex and hippocampus of these mice.
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Lab products found in correlation
2 protocols using emx1 cre transgenic mice
1
Genetic Engineering of miR-137 Knockout Mice
2
Transgenic Mouse Models for Muscular Dystrophy
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Emx1-Cre transgenic mice [33 (link)] were obtained from the Jackson Laboratories (Bar Harbor, ME, USA). POMT2-floxed mice have been reported [28 (link)]. These mice were purposely maintained on a 129SV and C57/B6 hybrid background to avoid artificial phenotypes that can be caused by homozygosity of inbred strains. Protocols for using laboratory mice were approved by the Institutional Committee for Use and Care of Laboratory Animals at State University of New York Upstate Medical University (CHUA#367) and adhered to the guidelines of the National Institutes of Health. All efforts were made to minimize pain and suffering of animals.
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