C57bl 6 h 2kb

Manufactured by Janvier Labs

Sourced in France

The C57BL/6 (H-2Kb) is a laboratory mouse strain commonly used in medical research. It is a major histocompatibility complex (MHC) class I H-2Kb haplotype mouse.

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Lab products found in correlation

Balb c h 2kd, by Janvier Labs (3 mentions) Vil cre, by Jackson ImmunoResearch (1 mentions) B6 cg tg vil1 cre 997gum j mice, by Jackson ImmunoResearch (1 mentions)

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C57BL/6 (101 citations)

4 protocols using c57bl 6 h 2kb

Mouse Immune Response Evaluation

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Animal studies were approved by the local regulatory authority (Regierung von Oberbayern, Munich). All experiments were performed in accordance with the relevant guidelines and regulations. C57BL/6 (H-2kb) and Balb/c (H-2kd) were purchased from Janvier Labs (France). IFNaR1-deficient mice (Ifnar1^−/−) were provided by Ulrich Kalinke and were previously described^{17 (link)}. Mice were between 6 and 10 weeks of age at the onset of experiments.

Fischer J.C., Bscheider M., Göttert S., Thiele Orberg E., Combs S.E., Bassermann F., Heidegger S., Haas T, & Poeck H. (2019). Type I interferon signaling before hematopoietic stem cell transplantation lowers donor T cell activation via reduced allogenicity of recipient cells. Scientific Reports, 9, 14955.

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Mice for Immunology Research

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C57BL/6 (H-2Kb) and BALB/c (H-2Kd) mice were purchased from Janvier Labs or from the local stock at the animal facility of Medical Center–University of Freiburg. Rag2^−/−Il2rg^−/− mice were obtained from the local stock at the animal facility of Medical Center–University of Freiburg. Mice were used between 6 and 14 weeks of age, and only female donors were used for female recipients and vice versa. Animal protocols were approved by the animal ethics committee Regierungspräsidium Freiburg, Freiburg, Germany (protocol numbers: X15/10A, G17-093, G17-063, and G20-075).

Uhl F.M., Chen S., O'Sullivan D., Edwards-Hicks J., Richter G., Haring E., Andrieux G., Halbach S., Apostolova P., Büscher J., Duquesne S., Melchinger W., Sauer B., Shoumariyeh K., Schmitt-Graeff A., Kreutz M., Lübbert M., Duyster J., Brummer T., Boerries M., Madl T., Blazar B.R., Groß O., Pearce E.L, & Zeiser R. (2020). Metabolic reprogramming of donor T cells enhances graft-versus-leukemia effects in mice and humans. Science translational medicine, 12(567), eabb8969.

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Murine Allogeneic Transplantation Model

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C57BL/6 (H-2K^b) and BALB/c (H-2K^d) mice were purchased from Janvier Labs (France) or from the local stock of the animal facility at University of Freiburg. Mice were used between 6 and 14 weeks of age, and only female or male donor/recipient pairs were used. Animal protocols were approved by the animal ethics committee Regierungspräsidium Freiburg, Freiburg, Germany (No: G-22/103, G17/63, G18/36, G20/078, G22/007).

Maas-Bauer K., Stell A.V., Yan K.L., de Vega E., Vinnakota J.M., Unger S., Núñez N., Norona J., Talvard-Balland N., Koßmann S., Schwan C., Miething C., Martens U.S., Shoumariyeh K., Nestor R.P., Duquesne S., Hanke K., Rackiewicz M., Hu Z., El Khawanky N., Taromi S., Andrlova H., Faraidun H., Walter S., Pfeifer D., Follo M., Waldschmidt J., Melchinger W., Rassner M., Wehr C., Schmitt-Graeff A., Halbach S., Liao J., Häcker G., Brummer T., Dengjel J., Andrieux G., Grosse R., Tugues S., Blazar B.R., Becher B., Boerries M, & Zeiser R. (2024). ROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease. Nature Communications, 15, 446.

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Genetically Engineered Mouse Models

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BALB/c (H-2K^d) and C57BL/6 (H-2K^b) mice were purchased from Janvier Labs (Le Genest-Saint-Isle, France). Luciferase-transgenic C57BL/6 mice (H-2K^b) were bred in the animal facility of the Center for Clinical Research at the Medical Center – University of Freiburg, Germany. Mice carrying a floxed Xbp1 allele (Xbp1^fl/fl) have been previously described^{17 (link)} and were a kind gift from Dr. Laurie Glimcher, Cornell University, USA. B6. Cg-Tg(Vil^1-cre)997Gum/J mice expressing the Cre recombinase in villus and crypt intestinal epithelial cells (Vil^Cre) were purchased from the Jackson Laboratory. Vil^CreXbp1^fl/fl mice and Xbp1^fl/fl littermates were generated by crossing these two strains. All animals were housed under specific pathogen-free conditions at the animal facility of the Center for Clinical Research (ZKF, Freiburg, Germany). Genotypes were confirmed via polymerase chain reaction (PCR). All animal protocols (G-16/018, G-17/063, G-18/063; X-13/07J; X-15/10A; X20/06K) were approved by the Federal Ministry for Nature, Environment and Consumer Protection of the state of Baden-Württemberg, Germany.
All other methods are provided in the Online Supplementary Appendix.

Haring E., Andrieux G., Uhl F.M., Krausz M., Proietti M., Sauer B., Esser P.R., Martin S.F., Pfeifer D., Schmitt-Graeff A., Duyster J., Köhler N., Grimbacher B., Boerries M., Aumann K., Zeiser R, & Apostolova P. (2021). Therapeutic targeting of endoplasmic reticulum stress in acute graft-versus-host disease. Haematologica, 107(7), 1538-1554.

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