For evaluation of suspected splenic tissue, a median of activity of 148 MBq (Q1–Q3 interquartile range, 140–153 MBq) technetium-99m heat damaged RBCs were prepared as described previously [4 ] and administered intravenously. SPECT and planar imaging were performed on a dual-headed Siemens Symbia T2 SPECT/CT or a Siemens Symbia Intevo T16 SPECT/CT system (Siemens Healthineers, Erlangen, Germany), using a low-energy high-resolution collimator. Planar images of the abdomen were acquired over 10 min. SPECT/low dose CT scan was initiated 30 min after tracer injection. SPECT acquisition parameters were 32 projections per head with 25 s per projection and a projection matrix of 128 × 128 pixels (4.7952 × 4.7952 mm2). SPECT reconstruction was performed via Hermes (Hermes Medical Solutions, Stockholm, Sweden) using the OSEM algorithm (3 iterations and 16 subsets) with Gaussian post-filtering of 1.10 cm full-width-half-maximum and included CT-based attenuation correction as well as resolution compensation. For further evaluation, SPECT images were transferred to a Hermes workstation.
Symbia t2 spect ct
Manufactured by Siemens
Sourced in Germany
The Symbia T2 is a SPECT/CT imaging system manufactured by Siemens. It combines single-photon emission computed tomography (SPECT) and computed tomography (CT) technologies to provide comprehensive diagnostic imaging capabilities. The system is designed to acquire and integrate functional and anatomical information, enabling healthcare professionals to make informed clinical decisions.
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Lab products found in correlation
4 protocols using symbia t2 spect ct
1
Technetium-99m Damaged RBC Imaging
2
Quantitative 177Lu SPECT/CT Imaging Protocol
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For dose calculation, several 3D datasets were used. All images were acquired on a hybrid Siemens Symbia T2 SPECT/CT. The acquisition and reconstruction were done based on our standard quantitative 177Lu protocol, which is in detail described in Ref. [17 (link)]. For this, only the key points of the protocol are listed in the following:
SPECT
SPECT
Calibrated to kBq/mL based on phantom measurements.
Medium energy collimator.
3° angular sampling, 60 stops (2 projections) for 15 s, 15-min total dwell time.
Iterative ordered subset expectation maximization (OSEM) reconstruction of the 208 keV photopeak data with 16 iteration 8 subsets, matrix 128 × 128.
Point-spread-function modelling in reconstruction.
Triple energy window-based scatter correction.
CT-based attenuation correction (CT taken from 24 h p.i. SPECT/CT).
No post-reconstruction smoothing.
Slice collimation of 2 × 5 mm, pitch of 1.8, time per rotation of 0.8 s, tube voltage of 130 kVp, Siemens CareDose 4D tube-current modulation with 30 mAs reference.
Filtered Back Projection reconstruction with B08s and B41s Kernels, 512 × 512 matrix, 2:5 mm slice thickness.
B08s image was used for attenuation correction of the SPECT data.
Down-sampling of B41s to match the lower resolution of the SPECT image (4.79 × 4.79 × 4.79 mm3).
3
Quantitative SPECT Dosimetry Protocol
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Data for dosimetry were acquired during a routine 4-day in-patient stay following the radiopharmaceutical injection, in conjunction with standard clinical examinations. All patients received a 15-min one-bed abdominal SPECT scan and a 20-min whole-body planar scintigraphy at 24, 48, and 72 h post-injection (p. i.) on a dual-headed Symbia T2 SPECT/CT (Siemens Medical Solutions, Erlangen, Germany). Counts were detected for the photopeak window of 208 keV (width 15%) by the usage of a medium-energy low-penetration collimator. Two additional scatter windows were measured at 170 keV (width 15%) and 240 keV (width 10%). A low-dose AC-CT was acquired at the first image acquisition session for anatomical correlation and attenuation correction during quantitative SPECT reconstruction. For the determination of the absorbed dose to the bone marrow from the activity circulating in the blood, five venous blood samples were drawn from the site contralateral to injection at 30 and 80 min p. i. and 24, 48, and 72 h p. i. [9 (link), 20 (link)].
4
Quantitative 99mTc-MAA SPECT/CT Protocol
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2.2.2.1. 99m Tc-MAA-SPECT/CT. Within 1.5 h post injection of 99m Tc-MAA into the (right and/or left) hepatic artery according to the planned catheter position for radioembolization, the patients were examined on a dual-head Symbia T2 SPECT/CT (Siemens Healthcare, Germany) with a low-energy-high-resolution collimator. SPECT projections were acquired with an energy window centered at the 99m Tc photopeak of 140 keV (±7.5%) and with an additional scatter window at 115 keV (±10%) in a 128x128 matrix with 32 angular steps per head with 25 s per step [2] . Quantitative SPECT reconstruction was performed (5 MAP iterations, 16 subsets, penalty of 0.001, collimator-specific depth-dependent detector response, voxel size (4.7952 mm) 3 ) [32] using the corresponding low dose CT (voxel size 0.9766 × 0.9766 × 5.0 mm 3 ) for attenuation correction and the dual energy window method for scatter correction. A previously determined nuclide-, collimator-and cameraspecific calibration factor, derived from a cylindrical phantom, was used for converting the measured counts per second per voxel to Becquerel per milliliter.
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