Leksell gamma knife perfexion unit

Manufactured by Elekta

Sourced in Sweden

The Leksell Gamma Knife Perfexion Unit is a stereotactic radiosurgery device designed for non-invasive treatment of brain disorders. It utilizes multiple, precisely focused gamma radiation beams to deliver a high dose of radiation to a targeted area of the brain while minimizing exposure to surrounding healthy tissue.

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Lab products found in correlation

Leksell model c unit, by Elekta (2 mentions) Leksell gammaplan treatment planning system, by Elekta (2 mentions)

Close spelling variants of this product

Leksell Gamma Knife Perfexion Leksell Gamma Knife Unit Gamma Knife Perfexion Leksell Gamma Knife Gamma Knife unit Perfexion Unit Gamma Knife Perfexion

4 protocols using leksell gamma knife perfexion unit

Stereotactic Radiosurgery for AVMs

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The procedure for GKRS has been previously described [19 (link),20 (link)]. In brief, all patients underwent stereotactic frame placement and stereotactic planning neuroimaging, using MRI and digital subtraction angiography (DSA). Radiosurgery was performed using the Leksell Gamma Knife Perfexion Unit (Elekta AB, Elekta Company, Stockholm, Sweden). The AVM nidus was delineated using stereotactic MRI, including T1-weighted contrast-enhanced and T2-weighted imaging sequences, and DSA. Dose planning was performed by a neurosurgeon and a medical physicist depending on AVM nidus location and calculated lesion volume.

Kim M.J., Park S.H., Park K.Y., Jung H.H., Chang J.H., Chang J.W., Lee J.W, & Chang W.S. (2020). Gamma Knife Radiosurgery Followed by Flow-Reductive Embolization for Ruptured Arteriovenous Malformation. Journal of Clinical Medicine, 9(5), 1318.

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Stereotactic Radiosurgery for Brain Metastases

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Patients were evaluated and consented by a radiation oncologist and neurosurgeon before GKRS. Patients were treated with a Leksell model C unit (Elekta, Norcross, GA) before May 2009 and with a Leksell GammaKnife Perfexion unit (Elekta) thereafter. Before undergoing radiosurgery, the patient underwent a 1.5T or 3T high-resolution contrast-enhanced stereotactic MRI and/or CT study of the brain. Treatment planning was performed using the Leksell GammaPlan treatment planning system (Elekta). Dose prescription was determined according to size and volume of the metastasis, and generally following the guidelines published by Shaw et al (12 (link)) for single-fraction radiosurgical treatment of previously irradiated primary brain tumors and brain metastases.

Lucas JT J.r., Colmer HG I.V., White L., Fitzgerald N., Isom S., Bourland J.D., Laxton A.W., Tatter S.B, & Chan M.D. (2015). Competing Risk Analysis of Neurologic versus Nonneurologic Death in Patients Undergoing Radiosurgical Salvage After Whole-Brain Radiation Therapy Failure: Who Actually Dies of Their Brain Metastases?. International journal of radiation oncology, biology, physics, 92(5), 1008-1015.

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Leksell Gamma Knife Stereotactic Radiosurgery

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Before April 2014, all of the patients were treated with Leksell Gamma Knife Unit B. Leksell Gamma Knife Perfexion Unit (Elekta Instrument, Inc.) was used from April 2014 to the present. Patients were placed with Leksell stereotactic frame G and underwent stereotactic MR imaging with contrast through the entire brain for target delineation. GKRS plan was designed by a radiation oncologist, medical physicist, and neurosurgeon. 4 or 8 mm collimator was used for better conformality.

Fu J., Wu L., Peng C., Yang X., You H., Cao L., Deng Y, & Yu J. (2020). Initial Gamma Knife Radiosurgery for Large or Documented Growth Asymptomatic Meningiomas: Long-Term Results From a 27-Year Experience. Frontiers in Oncology, 10, 598582.

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Stereotactic Radiosurgery for Brain Metastases

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Prior to treatment failure, all patients had been treated with Gamma Knife radiosurgery (Leksell Model C unit prior to May 2009, Leksell Gamma Knife Perfexion unit after May 2009; Elekta AB, Stockholm, Sweden). Prior to radiosurgery, patients underwent a high-resolution contrast-enhanced stereotactic MRI study of the brain. Treatment planning was performed using the Leksell GammaPlan Treatment Planning System (Elekta AB). Dose prescription was determined based on size and volume of each metastasis, generally following the guidelines published by Shaw et al. for single fraction radiosurgical treatment of brain metastases [8 (link)]. The median marginal dose of the previously treated lesion was 18 Gy (range 10– 24 Gy) and the median resected volume at the time of stereotactic radiosurgery failure was 4.9 cc (range 0.2–53 cc).

Mu F., Lucas JT J.r., Watts J.M., Johnson A.J., Bourland J.D., Laxton A.W., Chan M.D, & Tatter S.B. (2015). Tumor resection with carmustine wafer placement as salvage therapy after local failure of radiosurgery for brain metastasis. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 22(3), 561-565.

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