Cyclen

Manufactured by Strem Chemicals

Sourced in United States

Cyclen is a macrocyclic organic compound with the chemical formula C₄H₁₂N₄. It is a tetradentate ligand that can coordinate to metal ions, forming complexes with a wide range of applications in chemistry and materials science.

Automatically generated - may contain errors

Lab products found in correlation

Deuterated nmr solvents, by Cambridge Isotopes (1 mentions) Vnmrs 500 nmr spectrometer, by Agilent Technologies (1 mentions) Mq60 nmr analyzer, by Agilent Technologies (1 mentions) Eucl3, by Thermo Fisher Scientific (1 mentions) Nmr system 500, by Agilent Technologies (1 mentions) Cyclam, by Thermo Fisher Scientific (1 mentions) 1100 series, by Agilent Technologies (1 mentions)

4 protocols using cyclen

Lanthanide Complex Synthesis and Characterization

Check if the same lab product or an alternative is used in the 5 most similar protocols

All air- and water sensitive procedures were carried out using standard Schlenk techniques. Deuterated NMR solvents were purchased from Cambridge Isotope Laboratories (MA) and used as received. Hexahydrates of GdCl₃, YCl₃, and EuCl₃ were obtained from Alfa Aesar (REacton, Ward Hill, MA). Cyclen and DOTA were purchased from Strem Chemicals (Newburyport, MA). All other organic solvents and bulk inorganic reagents were purchased from EM Science (Gibbstown, NJ) and used as received, except where indicated. Distilled water was purchased from Arrowhead (Louisville, KY). Dionized water was generated from a PURELAB Ultra Mk2 water purifier (Elga). ¹H T₁ measurements were acquired on a Varian 400MR NMR Spectrometer at 9.4 T, or on a Bruker mq 60 NMR Analyzer at 1.4 T. ¹⁹F-NMR spectra were acquired on a Varian VNMRS 500 NMR Spectrometer at 11.7 T. Chemical shifts were referenced to residual solvent (¹H) or C₆F₆ (¹⁹F).

Wu X., Dawsey A.C., Siriwardena-Mahanama B.N., Allen M.J, & Williams T.J. (2014). A (Fluoroalkyl)Guanidine Modulates the Relaxivity of a Phosphonate-Containing T1-Shortening Contrast Agent. Journal of fluorine chemistry, 168, 177-183.

+ Open protocol

+ Expand

Synthesis and Purification of Cyclen and DOTA

Check if the same lab product or an alternative is used in the 5 most similar protocols

Cyclen (1,4,7,10-tetraazacyclododecane) was purchased from Strem Chemicals, MA, USA. DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) was purchased from Sigma-Aldrich. Dry DMF was purchased from Fluka. Dry acetonitrile was purchased from Acros. Potassium carbonate was dried at 105 °C for 1 h before use. 4A and 3A (for alcohols only) molecular sieves were activated in a furnace at 300 °C for 3 h before use. Tetrahydrofuran was distilled from potassium and benzophenone, dioxane was distilled from lithium aluminium hydride, chloroform, and chlorobenzene were distilled from calcium hydride. All solvents were distilled under nitrogen and stored over 4A molecular sieves.

Bruce J.I., O’Connell P.J., Taylor P.G., Smith D.P., Adkin R.C, & Pearson V.K. (2020). Synthesis of Organosilicon Ligands for Europium (III) and Gadolinium (III) as Potential Imaging Agents. Molecules, 25(18), 4253.

+ Open protocol

+ Expand

Lanthanide-Based Organic Synthesis

Check if the same lab product or an alternative is used in the 5 most similar protocols

All chemicals and solvents were used as supplied from commercial sources. The lanthanide salts and cyclen were purchased from Strem Chemicals, Newburyport, MA, USA. All other chemicals were supplied by Sigma Aldrich, St. Louis, MO, USA or Alfa Aesar, Haverhill, MA, USA. Silicon wafer (110) was supplied by Siltronix, Archamps, France.

Bahuleyan B.K., Toussaint K., Rinnert H., Vallon R., Molinari M., Chuburu F, & Cadiou C. (2019). Silicon Wafer Functionalization with a Luminescent Tb(III) Coordination Complex: Synthesis, Characterization, and Application to the Optical Detection of NO in the Gas Phase. Molecules, 24(10), 1914.

+ Open protocol

+ Expand

Spectroscopic Characterization of Compounds

Check if the same lab product or an alternative is used in the 5 most similar protocols

¹H and ¹³C NMR spectra were recorded on a Varian 500 NMR system. LC-MS was performed by using an Agilent 1100 Series apparatus with an LC/MSD trap and Daly conversion dynode detector with UV detection at λ=220, 254, and 280 nm. Chemicals were supplied by Aldrich Chemical, TCI America, and Acros, and were used without further purification. Solvents (HPLC grade) were purchased from various commercial suppliers and used as received. Cyclam was received from Alfa Aesar; cyclen was obtained from Strem Chemicals. Purification of intermediates by HPLC was performed by using the HPLC method after injection of the filtered, crude mixture onto preparative HPLC (Rainin, Dynamax, column: 250 mm Phenomenex C18).

Boros E., Holland J.P., Kenton N., Rotile N, & Caravan P. (2016). Macrocycle-Based Hydroxamate Ligands for Complexation and Immunoconjugation of 89Zirconium for Positron Emission Tomography (PET) Imaging. ChemPlusChem, 81(3), 274-281.

+ Open protocol

+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!