Optima LC/MS grade acetonitrile, methanol and water, N,N-dimethylformamide (DMF), and 4-(4, 6-dimethoxy-1, 3, 5-triazin-2-yl)-4-methylmorpholinium chloride (DMTMM) were purchased from Fisher Scientific (Fair Lawn, NJ). N-methylmorpholine (NMM) was purchased from TCI America (Tokyo, Japan). 12 Metabolite standards (histidine, valine, tyrosine, leucine, lysine, phenylalanine, tryptophan, alanine, serotonin, dopamine, γ-aminobutyric acid, and norepinephrine), 3-aminoquinoline, and triethylammonium bicarbonate (TEAB) was purchased from Sigma (St. Louis, MO). Formic acid (FA) (≥98%) was obtained from Fluka (Büchs, Switzerland). C18 and OMIX SCX Ziptips were purchased from Millipore and Agilent, respectively. Deionized water (18.2 MΩ·cm) was prepared with a Milli-Q Millipore system (Billerica, MA).
3 aminoquinoline
Manufactured by Merck Group
Sourced in United States
3-aminoquinoline is a chemical compound that serves as a precursor in the synthesis of various pharmaceutical and agrochemical products. It is a heterocyclic aromatic organic molecule composed of a benzene ring fused to a pyridine ring, with an amino group attached to the quinoline structure. This compound is commonly used as an intermediate in the production of more complex chemical substances, though its specific applications may vary depending on the needs of the end-user.
Automatically generated - may contain errors
Lab products found in correlation
Nmr spectrophotometer, by Bruker (2 mentions)
Ftir spectrophotometer, by PerkinElmer (2 mentions)
Triethylammonium bicarbonate, by Merck Group (1 mentions)
N n dimethylformamide (dmf), by Thermo Fisher Scientific (1 mentions)
N methylmorpholine, by Tokyo Chemical Industry (1 mentions)
Millipore milli q system, by Merck Group (1 mentions)
Optima lc ms grade acetonitrile, by Thermo Fisher Scientific (1 mentions)
Model 2400 chnso analyzer, by PerkinElmer (1 mentions)
Model 2400 chnso analyser, by PerkinElmer (1 mentions)
3 protocols using 3 aminoquinoline
1
Metabolite Quantification by LC-MS
2
Spectroscopic Analysis of 3-Aminoquinoline Derivatives
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Melting points were uncorrected and determined in an open capillary on a Gallen Kamp melting point apparatus (Sanyo Gallen Kamp, UK). Precoated silica gel plates (Kieselgel 0.25 mm, 60 F254, Merck, Germany) were used for thin layer chromatography. A developing solvent system of chloroform/methanol (8:2) was used and the spots were detected by UV light. IR spectra (KBr disc) were recorded using an FT-IR spectrophotometer (Perkin Elmer, USA). 1 H NMR spectra were scanned on a NMR spectrophotometer (Bruker AXS Inc., Switzerland) operating at 500 MHz for 1 H-and 125.76 MHz for 13 C. Chemical shifts are expressed in d-values (ppm) relative to TMS as an internal standard, using DMSO-d 6 as a solvent. Elemental analyses were done on a model 2400 CHNSO analyzer (Perkin Elmer, USA). All the values were within ± 0.4 % of the theoretical values. All reagents used were of analytical grade. The starting material 3-aminoquinoline was purchased from Sigma (USA) and was directly used for the preparation of target compounds.
3
Synthesis and Characterization of 3-Aminoquinoline Derivatives
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Melting points (uncorrected) were determined in an open capillary in a Gallenkamp melting point apparatus (Sanyo Gallenkamp, UK). Precoated silica gel plates (Kieselgel 0.25 mm, 60 F254, Merck, Germany) were used for thin layer chromatography. A developing solvent system of chloroform/methanol (8:2) was used and the spots were detected by ultraviolet light. IR spectra (KBr disc) were recorded using an FT-IR spectrophotometer (Perkin Elmer, USA). 1 H NMR spectra were scanned on a NMR spectrophotometer (Bruker AXS Inc., Switzerland), operating at 500 MHz for 1 H-and 125.76 MHz for 13 C NMR. Chemical shift s are expressed in d values (ppm) relative to TMS as an internal standard, using DMSO-d 6 as a solvent. Elemental analyses were done on a model 2400 CHNSO analyser (Perkin Elmer, USA). All values were within ±0.4 % of the theoretical values. All reagents used were of AR grade. The starting material 3-aminoquinoline was purchased from Sigma (USA) and was directly used for the preparation of target compounds.
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