Grip strength apparatus

Manufactured by Bioseb

Sourced in France

The Grip-strength apparatus is a laboratory device designed to measure the grip strength of users. It provides a quantitative assessment of the force exerted by the user's hand and fingers.

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Lab products found in correlation

Rotarod test, by Ugo Basile (1 mentions) Prism 9, by GraphPad (1 mentions) Accurotor four channel, by Omnitech Electronics (1 mentions)

20 protocols using grip strength apparatus

Assessing Compound 14's Neuropharmacological Effects

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In this study, we used adult male Swiss albino mice (Kołacz, Laboratory Animals Breeding, Warszawa, Poland) license no. 106/2019 (Local Ethical Committee in Lublin). In studies assessing the acute effect of compound 14 on neuromuscular strength, body temperature, and seizure threshold, compound 14 was suspended in a 1% solution of Tween 80 and administered i.p., 30 min before the tests.
The timed ivPTZ test was employed to evaluate the acute effect of compound 14 on the seizure thresholds for (1) the first myoclonic twitch, (2) generalized clonic seizure with loss of righting reflex, and (3) forelimb tonus. The experimental procedure was described in detail elsewhere [26 (link)]. The changes in temperature were recorded using an electronic thermometer (ThermoWorks, Alpine, UT, USA). Mice were gently restrained and a rectal probe was inserted to a depth of ~2 cm into the rectum.
The probe remained in the rectum for several second, allowing for temperature stabilization. The temperature was recorded just before injection of compound 14 or vehicle and 30 min later. The difference between the pre- and post-injection temperature value was then calculated (Δ °C).
The acute effect of compound 14 on neuromuscular strength was quantified using the grip-strength apparatus (BIOSEB, Chaville, France) according to the method described elsewhere [26 (link)].

Abram M., Jakubiec M., Rapacz A., Mogilski S., Latacz G., Szulczyk B., Szafarz M., Socała K., Nieoczym D., Wyska E., Wlaź P., Kamiński R.M, & Kamiński K. (2021). Identification of New Compounds with Anticonvulsant and Antinociceptive Properties in a Group of 3-substituted (2,5-dioxo-pyrrolidin-1-yl)(phenyl)-Acetamides. International Journal of Molecular Sciences, 22(23), 13092.

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Grip Strength Modulation by AED Combinations

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The effects of combinations of modafinil (50 mg kg⁻¹), sulfone and acid metabolites (50 mg kg⁻¹), or GBR 12909 (25 mg kg⁻¹) with different classical AEDs at doses corresponding to their ED₅₀ values from the MES test on skeletal muscular strength in mice were quantified by the grip strength test of Meyer et al. (1979 (link)). The grip strength apparatus (BioSeb, Chaville, France) comprised a wire grid (8 × 8 cm) connected to an isometric force transducer (dynamometer). The mice were lifted by the tails so that their forepaws could grasp the grid. The mice were then gently pulled backward by the tail until the grid was released. The maximal force exerted by the mouse before losing grip was recorded. The mean of three measurements for each animal was calculated, and subsequently, the mean maximal force of eight animals per group was determined. The muscular strength in mice is expressed in N (newtons) as the means ± S.E.M. of at least eight determinations.

Zolkowska D., Andres-Mach M., Prisinzano T.E., Baumann M.H, & Luszczki J.J. (2015). Modafinil and its metabolites enhance the anticonvulsant action of classical antiepileptic drugs in the mouse maximal electroshock-induced seizure model. Psychopharmacology, 232(14), 2463-2479.

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Measuring Skeletal Muscle Strength in Mice

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The effect of hypoxia on skeletal muscular strength was assessed by a grip-strength test [44 (link)]. The grip-strength apparatus (BioSeb, Chaville, France) consisted of a wire crossbar connected to an isometric force transducer or dynamometer. Male mice at P90 were lifted by their tails until their forepaws could grasp the grid. The mice were then gently pulled backward by the tail until the bar was released. The maximal force exerted by the mouse before losing grip was recorded. The mean of three measurements for each animal was calculated and normalized to the animal’s body weight, with the resulting data expressed as Newtons per gram (N/g) [45 (link)].

Watzlawik J.O., Kahoud R.J., O’Toole R.J., White K.A., Ogden A.R., Painter M.M., Wootla B., Papke L.M., Denic A., Weimer J.M., Carey W.A, & Rodriguez M. (2015). Abbreviated Exposure to Hypoxia Is Sufficient to Induce CNS Dysmyelination, Modulate Spinal Motor Neuron Composition, and Impair Motor Development in Neonatal Mice. PLoS ONE, 10(5), e0128007.

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Grip Strength Evaluation of Neuroactive Compounds

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The effects of single doses of TC-G 1008, ZnCl₂, or VPA or repeated doses of these compounds and PTZ kindling on skeletal and muscular strength were evaluated in Swiss Albino or C57BL/6/Tar × CBA/Tar mice using the grip-strength test [46 (link)]. The grip-strength apparatus (BioSeb, Chaville, France) consisted of a steel wire grid (8 × 8 cm) connected to an isometric force transducer. A mouse was lifted by its tail to grasp the grid with its forepaws. The mouse was then gently pulled back until it released the grid, and the maximal force in newtons (N) exerted by the mouse before losing grip was measured. The procedure was repeated three times, and the mean force exerted by each mouse before losing grip was recorded. The mean force was normalized to body weight and expressed in mN/g ± SEM.

Doboszewska U., Socała K., Pieróg M., Nieoczym D., Sawicki J., Szafarz M., Gawel K., Rafało-Ulińska A., Sajnóg A., Wyska E., Esguerra C.V., Szewczyk B., Maćkowiak M., Barałkiewicz D., Mlyniec K., Nowak G., Sowa I, & Wlaź P. (2023). TC-G 1008 facilitates epileptogenesis by acting selectively at the GPR39 receptor but non-selectively activates CREB in the hippocampus of pentylenetetrazole-kindled mice. Cellular and Molecular Life Sciences, 80(5), 133.

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Comprehensive Neurobehavioral Assessment in Mice

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All behavioral experiments were performed at the UCSF Neurobehavioral Core for Rehabilitation Research. Mice were habituated to the experimenter through handling, weighting and cage change starting one week prior to behavioral testing. Experiments were all performed at the same time of the day for each day of testing. The rotarod test (Ugo Basile) was performed to assess motor coordination and motor learning. Mice were placed onto a rotating rod accelerating from 0-40 rotations per minute during 5 minutes. Animals were tested 3 times per day (T1, T2, T3) for 3 consecutive days (D1, D2, D3) and the latency to fall from the apparatus at each trial was measured. Forelimb grip strength was measured using a grip strength apparatus (Bioseb). The grip strength of each mouse was measured on 3 trials per day for 3 consecutive days and the average peak force per animal was computed. The open field test (Kinder-Scientific) was used to assay overall locomotor activity. Mice were let to freely explore an open arena connected to a video tracking software for 10 min. Data collected includes distance traveled and number of rearings (exploratory behavior where mice stands on its hind legs).

Haim L.B., Schirmer L., Zulji A., Sabeur K., Tiret B., Ribon M., Chang S., Lamers W.H., BoillEée S., Chaumeil M.M, & Rowitch D.H. (2021). Evidence for glutamine synthetase function in mouse spinal cord oligodendrocytes. Glia, 69(12), 2812-2827.

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Assessing Mouse Grip Strength

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The grip-strength apparatus (BioSeb, Chaville, France) comprised of a wire grid (8 × 8 cm) connected to an isometric force transducer (dynamometer). Mice were lifted by the tail so that their forepaws could grasp the grid. The mice were then gently pulled backward by the tail until the grid was released. The mean of three consecutive measurements for each mouse was calculated. The muscular strength was expressed in Newton (N) as mean ± SEM.

Gangarossa G., Laffray S., Bourinet E, & Valjent E. (2014). T-type calcium channel Cav3.2 deficient mice show elevated anxiety, impaired memory and reduced sensitivity to psychostimulants. Frontiers in Behavioral Neuroscience, 8, 92.

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Grip Strength in Mice: Tadalafil and Antiepileptics

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The acute effects of tadalafil, antiepileptic drugs, and their combinations with tadalafil on skeletal muscular strength in mice were quantified in the grip-strength test. The grip-strength apparatus (BioSeb, Chaville, France) consisted of a steel wire grid (8 × 8 cm) connected to an isometric force transducer. The animal was lifted by its tail so that it could grasp the grid with its forepaws. The mouse were then gently pulled backward until it released the grid and the maximal force in newtons (N) exerted by the mouse before losing grip was measured. The procedure was repeated three times and the mean force exerted by each mouse before losing grip was recorded. The mean force was then normalized to body weight and expressed in mN/g ± SE.

Socała K., Nieoczym D., Pieróg M., Wyska E., Szafarz M., Doboszewska U, & Wlaź P. (2018). Effect of Tadalafil on Seizure Threshold and Activity of Antiepileptic Drugs in Three Acute Seizure Tests in Mice. Neurotoxicity Research, 34(3), 333-346.

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Grip Strength Measurement in Mice

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The grip-strength apparatus (BioSeb, Chaville, France) consisted of a steel wire grid (8 cm × 8 cm) connected to an isometric force transducer. Animals were lifted by their tails so that they could grasp the grid with their forepaws. The mice were then gently pulled backward until they released the grid. The maximal force in newtons (N) exerted by the mouse before losing grip was measured. The procedure was repeated three times and the mean force exerted by each mouse before losing grip was recorded. Since body weight affects the grip force, the mean force was normalized to body weight and expressed in mN/g and SEM.

Pieróg M., Socała K., Nieoczym D., Wyska E., Samorek-Pieróg M, & Wlaź P. (2023). Anticonvulsant Profile of Selected Medium-Chain Fatty Acids (MCFAs) Co-Administered with Metformin in Mice in Acute and Chronic Treatment. Molecules, 28(9), 3810.

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Measuring Sensorimotor Deficits in Focal Cerebral Ischemia

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We used the grip strength test as the second assessment to measure sensorimotor deficits associated with fCI, following a previous study’s protocol [35 (link)]. Briefly, after completing the NDS, mice (n = 10 per group) were placed on a wire grid connected to a grip strength apparatus (BioSeb, Chaville, France), and their grip strength was measured as they grasped the grid with both forepaws and were gently pulled until they released their grip. The maximum force exerted was recorded in grams (g). The average values for each group were expressed as a percentage of the SO group. All tests were conducted in triplicate.

Eom S.H., Hong G.L., Kang H.B., Lee N.S., Kim D.K., Jeong Y.G., Kim C.S., Yoo Y.C., Lee B.H., Jung J.Y., Kim D.S, & Han S.Y. (2023). Neuroprotective Effects of Water Extract from Brown Algae Petalonia binghamiae in an Experimental Model of Focal Cerebral Ischemia In Vitro and In Vivo. Current Issues in Molecular Biology, 45(10), 8427-8443.

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Grip Strength Analysis of GFP-PR28 Mice

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The muscular strength of 20-day-old GFP-PR₂₈ homozygous mice, 6-month-old GFP-PR₂₈ heterozygous mice, and control mice were measured with a grip strength apparatus (Bioseb). After the mice grasped the grid with its hind paws or four paws, pulled backward gently until the mice released, the strength measured in gram was recorded, and the average strength of each mice was calculated in five intermittent measures.

Hao Z., Liu L., Tao Z., Wang R., Ren H., Sun H., Lin Z., Zhang Z., Mu C., Zhou J, & Wang G. (2019). Motor dysfunction and neurodegeneration in a C9orf72 mouse line expressing poly-PR. Nature Communications, 10, 2906.

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