We performed a Genome Wide Association Study (GWAS) analysis in 458,577 UKB participants13 (
link) (
Supplementary Methods). These consist of 408,951 individuals from UKB genotyped at 825,927 variants with a custom Affymetrix UK Biobank Axiom Array chip and 49,626 individuals genotyped at 807,411 variants with a custom Affymetrix
UK BiLEVE Axiom Array chip from the UK BiLEVE study57 (
link), which is a subset of UKB. SNPs were imputed centrally by UKB using a reference panel that merged the UK10K and 1000 Genomes Phase 3 panel as well as the Haplotype Reference Consortium (HRC) panel58 . For current analysis only SNPs imputed from the HRC panel were considered.
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