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¹H and ¹³C NMR spectra were recorded on a JEOL ECZ500 (500 MHz for ¹H NMR) or a JEOL ECZ400 (400 MHz for ¹H NMR) spectrometers. Chemical shifts are denoted in δ (ppm) relative to residual solvent peaks as internal standard (DMSO-d₆, ¹H δ 2.50, ¹³C δ 39.5). ESI-MS spectra were measured by a Thermo Scientific Exactive mass spectrometer or a SHIMADZU LCMS-2050 spectrometer. Optical rotations were recorded on a JASCO P-1030 polarimeter. High-performance liquid chromatography (HPLC) experiments were performed with a SHIMADZU HPLC system equipped with a LC-20AD intelligent pump. MS/MS analysis was performed with amaZon SL-NPC (Bruker Daltonics) using helium gas with an amplitude value 1.0 V. The chemical structures of enzyme substrates and enzymatic reaction products are analyzed by MS/MS (Supplementary data 1) and/or NMR (Supplementary data 2). All reagents were used as supplied unless otherwise noted.

All chemicals were purchased from Wako Pure Chemical Industries (Osaka, Japan), Kanto Chemicals (Tokyo, Japan) and Nacalai Tesque (Kyoto, Japan).
Optical rotations were measured on a JASCO P-1030 polarimeter. NMR spectra were recorded on a JEOL ECA 500 (500 MHz) spectrometer. Chemical shifts are denoted in δ (ppm) relative to residual solvent peaks as internal standards (CD₃OD: δ_H 3.31, δ_C 49.0). LC–MS experiments and ESI–TOF MS/MS analyses were performed with an amaZon SL-NPC (Bruker Daltonics) or LCMS-2020 (Shimadzu) spectrometer coupled with a Shimadzu HPLC system equipped with an LC-20AD intelligent pump. GC–MS experiments were performed with a Shimadzu-QP2010 Ultra system. HRESIMS analyses were performed with a Thermo Scientific LTQ Orbitrap XL (LTQ XL coupled with LTQ QR) spectrometer.