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Bezafibrate beza

Manufactured by Merck Group
Sourced in United States

Bezafibrate (BEZA) is a pharmaceutical compound used in the production of various laboratory equipment. It is a synthetic fibric acid derivative with lipid-regulating properties. Bezafibrate is utilized in the manufacture of specialized laboratory instruments and devices, providing specific functionalities required for various research and analytical applications.

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3 protocols using bezafibrate beza

1

Mitochondrial Function Optimization

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Etomoxir (ETO) and STO-609 was purchased from TOCRIS (Tocris Bioscience, UK). Bezafibrate (BEZA), CCCP, and H2O2 were obtained from Sigma (St. Louis, MO, USA). Oligomycin was purchased from Cell Signaling Technology (USA). cyclosporin A (CsA) was obtained from Selleck Chemicals (USA) and BAPTA-AM was purchased from MedChemexpress Co. (USA). The calcium-sensitive indicator, Fluo-3 AM was purchased from Beyotime Co. (China). XF Palmitate-BSA FAO Substrate was obtained from seahorse Bioscience.
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2

Assessing Occurrence of Pharmaceuticals in Spanish Waters

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PPCPs and dose levels were selected on the basis of a meta-analysis of PPCP occurrence in Spanish freshwaters (details are in S2). The 16 PPCPs included in the present study encompassed (i) antibiotics: erythromycin (ERY, C10; >95%; Fluka) and ofloxacin (OFLO, C11; 99.9%; Sigma Aldrich); (ii) β-blockers: atenolol (ATE, C1; 91%; Sigma Aldrich), bezafibrate (BEZA, C2; ≥98%; Sigma Aldrich), and gemfibrozil (GEM, C4; >99%; Sigma Aldrich); (iii) stimulants: nicotine (NICO, C12; 99%; Sigma Aldrich) and caffeine (CAFE, C13; >99%; Sigma Aldrich); (iv) analgesics: ketoprofen (KETO, C8; >98%; TCI), ibuprofen (IBU, C7; ≥98%; Sigma Aldrich), paracetamol (PARA, C9; 99%; Sigma Aldrich), and diclofenac [DICLO, C6; ≥98% (sodium salt); Sigma Aldrich]; (v) diuretics: furosemide (FURO, C3; ≥98%; Sigma Aldrich) and HYDROchlorothiazide (HYDRO, C5; ≥99%; Sigma Aldrich); (vi) an antidepressant: venlafaxine (VENLA, C14; >98%; TCI); and (vii) anticonvulsants: carbamazepine (CARBA, C16; ≥98%; Sigma Aldrich) and primidone (PRIMI, C15; ≥98%; Sigma Aldrich). The Chemical Abstracts Service number and pharmacological family are summarized in S3. Additional information on preparation, handling of stock solutions, and chemical stability can be found in S2.
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3

PPAR Agonist Effects on Ethanol Drinking

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The PPARα agonist fenofibrate (feno) (Sigma-Aldrich, St. Louis, MO), pan-PPAR agonist bezafibrate (beza) (Sigma-Aldrich, St. Louis, MO) and dual PPARα-PPARγ agonist tesaglitazar (tesa) (Tocris Bioscience, Minneapolis, MN) were freshly prepared as suspensions in saline with 4–5 drops of Tween-80 and injected in a volume of 0.05 ml/10 g of body weight. We administered (p.o.) PPAR agonist (150 mg/kg, 75 mg/kg, or 1.5 mg/kg of feno, beza, and tesa, respectively) or saline for eight days. Doses of drugs and routes of administration were based on published biological activity in vivo. Tesa was only delivered for six days in the 2BC experiment because its decreased effect on ethanol drinking behavior plateaued at that time-point.
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