400 or500 mhz nmr spectrometer

Manufactured by Agilent Technologies

The 400 or 500 MHz NMR spectrometer is a laboratory instrument used for nuclear magnetic resonance (NMR) spectroscopy. It operates at a frequency of either 400 or 500 MHz, providing high-resolution analysis of molecular structures and compositions.

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Lab products found in correlation

Exactive orbitrap plus spectrometer, by Thermo Fisher Scientific (1 mentions) Ninhydrin, by Merck Group (1 mentions) Phosphomolybdic acid, by Merck Group (1 mentions) Silica gel plate, by Merck Group (1 mentions)

2 protocols using 400 or500 mhz nmr spectrometer

Synthesis and NMR Characterization of Novel Compounds

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The reagents and solvents were obtained from
commercial suppliers and used without further purification. ¹H and ¹³C NMR spectra were recorded on a Varian 400 or
500 MHz NMR spectrometer with dimethyl sulfoxide (DMSO)-d₆ as a solvent. Chemical shifts are referenced to the
residual solvent peak and reported in parts per million (ppm) (δ
scale), and all coupling constant (J) values are
given in hertz. Electrospray ionization-high-resolution mass spectrometry
(ESI-HRMS) data were measured on a Thermo Exactive Orbitrap plus spectrometer.
Melting points were determined on a Yanaco MP-J3 microscope melting
point apparatus. All microwave reactions were carried out in single-mode
CEM Explorer SP 48. Substrates 1, 2, and 11 were prepared according to the reported procedures.^{36 (link)−40 (link)}

Chen H., Li P., Qin R., Yan H., Li G, & Huang H. (2020). DMAP-Catalyzed One-Pot Synthesis of Quinazoline-2,4-diones from 2-Aminobenzamides and Di-tert-butyl Dicarbonate. ACS Omega, 5(16), 9614-9623.

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Characterization of Organic Compounds

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¹H and ¹³C NMR spectra were measured on a Bruker or Varian 400 or 500 MHz NMR spectrometer. Melting points were measured on a Mettler Toledo capillary melting point apparatus and are uncorrected. Specific rotations were measured on a RUDOLPH AUTOPOL IV-T. ESI high-resolution mass spectra (HRMS) was recorded on an Autospec Ultima-TOF spectrometer. A CEM Discovery Microwave Reactor was used for microwave synthesis. All reactions were monitored by thin layer chromatography (TLC) carried out on Merck silica-gel plates (0.25 mm thick, 60 F254), visualized by using UV (254 nm) or dyes such as ninhydrin or phosphomolybdic acid. Buffer salts (reagent grade or better), solvents (HPLC grade or better), and all the other chemicals were purchased from Fisher Scientific Co. The chemicals were purchased from Aldrich Co. and Sigma and purified before use by standard methods.

Li Z., Bao X., Bai X., Zhang G., Wang J., Zhu M., Wang Y., Shang J., Sheng C., Zhang D, & Wang Y. (2019). Design, Synthesis, and Biological Evaluation of Phenol Bioisosteric Analogues of 3-Hydroxymorphinan. Scientific Reports, 9, 2247.

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