Microferret

Manufactured by Cook Medical

Sourced in United States

The Microferret is a compact and versatile lab equipment designed for precision fluid handling. It features a high-precision pipetting mechanism capable of accurately dispensing small volumes of liquids. The Microferret is suitable for various laboratory applications that require accurate liquid transfer and sample preparation.

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Lab products found in correlation

Lipiodol, by Guerbet (3 mentions) Progreat, by Terumo (1 mentions) Radiofocus, by Terumo (1 mentions) 5 french catheter, by Cook Medical (1 mentions)

4 protocols using microferret

Transarterial Chemoembolization for Hepatocellular Carcinoma

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Details regarding the TACE procedure have been described previously [11 (link)]. Briefly, conventional TACE was selectively performed by infusion of a mixture of 10–60 mg of doxorubicin emulsion and 2–12 mL of iodized oil contrast medium (Lipiodol; Guerbet LLC, Bloomington, IN, USA) through a microcatheter (Microferret; Cook, Bloomington, IN, or Progreat; Terumo, Tokyo, Japan), followed by embolization using absorbable gelatin sponge particles 1 mm in diameter (Gelfoam; Upjohn, Kalamazoo, MI, or Cutanplast; Mascia Brunelli, Milano, Italy) soaked in a mixture of 10–20 mg doxorubicin hydrochloride and 10 mL of nonionic contrast medium.
Contrast-enhanced computed tomography (CT) was performed 4–8 weeks after TACE to assess the need for subsequent treatment. Repeated TACE was performed every 8–12 weeks if viable HCC (i.e., contrast enhancement during the arterial phase, washout in the portal, and delayed phase) was detected on imaging without liver function deterioration.

Cho E.J., Yu S.J., Lee Y.B., Lee J.H., Kim Y.J, & Yoon J.H. (2022). Prognostic Values of Inflammation-Based Scores and Fibrosis Markers in Patients with Hepatocellular Carcinoma Treated with Transarterial Chemoembolization. Diagnostics, 12(5), 1170.

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Hepatic Artery Infusion and Embolization

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With the patient under local anesthesia, right femoral access was obtained, and angiography of the superior mesenteric and common hepatic arteries was performed using a 5-Fr Rösch hepatic catheter (Radiofocus; Terumo, Tokyo, Japan). A 3-Fr microcatheter (MicroFerret; Cook, Indiana, USA) was coaxially placed into the proper, lobar, segmental, or subsegmental hepatic artery, and 500 to 1000 mg 5-fluorouracil was infused through the microcatheter for 10 to 15 min. Subsequently, 20 to 40 mg doxorubicin mixed at a 1:1 ratio in an emulsion of iodized oil (Lipiodol; Guerbet, France) was infused, which was followed by embolization with gelatin sponge pledgets (Gelfoam; Upjohn, Missouri, USA) until stasis or near stasis of arterial flow was achieved. Hemostasis at the access site was achieved by manual compression.

Zhao H., Tsauo J., Zhang X., Ma H., Weng N., Yang Z, & Li X. (2022). Prevalence and prognostic impact of hepatopulmonary syndrome in patients with unresectable hepatocellular carcinoma undergoing transarterial chemoembolization: a prospective cohort study. Chinese Medical Journal, 135(17), 2043-2048.

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Hepatic Artery Embolization for Hemangioma

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The femoral artery was punctured under local anesthesia using the Seldinger technique. After a celiac and superior mesenteric arteriography through a 5-French catheter (Cook, Bloomington, IN), the hepatic artery was catheterized. Hepatic arteriography was performed to confirm the arteries feeding the hemangiomas. Superselective cannulation of the feeding arteries was performed using a 3-French microcatheter (Microferret, Cook, Letchworth, UK). Then, the emulsion consisting of pingyangmycin (PYM, Zhejiang Hisun Pharmaceutical Co., Ltd., Taizhou City, China) and iodized oil (Lipiodol, Andre Gurbet, Aulnaysous-Bois, France Guerbet, France) was slowly injected for embolization under fluoroscopic guidance, followed by injection of gelatin sponge particles (1-2 mm in diameter) (Gelfoam1, Upjohn, Kalamazoo, MI), until the tumor-feeding arteries were saturated. The PLYin-lipiodol emulsion was prepared by emulsifying 2 mL of 5% glucose solution with 8 mg of PYL in 20 mL of iodized oil. After embolization, angiography was performed to assess the extent of vascular embolization and identify the presence of any residual lesion staining.

Shi Y., Song J., Ding M., Tang X., Wang Z., Chi J., Wang T., Ji J, & Zhai B. (2020). Microwave ablation versus transcatheter arterial embolization for large hepatic hemangiomas: clinical outcomes. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 37(1).

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Selective TACE Procedure for Liver Tumors

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All TACE procedures were performed by one of three interventional radiologists with at least 10 years' experience in interventional radiology. Depending on tumour size, location and arterial supply of the tumour, a 3-Fr microcatheter (Microferret ® ; Cook, Bloomington, Indiana, USA) was advanced towards the tumour-feeding arteries for selective embolization. TACE of the feeding arteries was achieved by further superselective catheterization as close to the tumour as possible. A mixture of doxorubicin hydrochloride (Adriamycin; Ildong, Seoul, Korea) and an emulsion of iodized oil (Lipiodol ® ; Laboratoire Guerbet, Aulnay-sous-Bois, France) was used for chemoembolization. The dose was determined according to lesion size and number, feeding vessels and liver function. After embolization, angiography was performed to determine the extent of vascular occlusion and to assess blood flow in other arterial vessels. Lesions exceeding 1 cm in diameter were embolized superselectively, whereas those measuring less than 1 cm were treated non-selectively. Complications were defined and graded according to the Society of Interventional Radiology guidelines 19 .

Lei J.Y., Zhong J.J., Yan L.N., Zhu J.Q., Wang W.T., Zeng Y., Li B., Wen T.F, & Yang J.Y. (2016). Response to transarterial chemoembolization as a selection criterion for resection of hepatocellular carcinomas. The British journal of surgery, 103(7).

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