C501 instrument

Manufactured by Roche

Sourced in Switzerland

The C501 instrument is a laboratory equipment designed for automated clinical chemistry analysis. It performs various biochemical tests on biological samples to aid in medical diagnosis and patient management. The C501 instrument is capable of performing a range of analytical procedures, but a detailed description of its core function is not available while maintaining an unbiased and factual approach.

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Lab products found in correlation

E411 analyzer, by Roche (1 mentions) Model 907, by Omron (1 mentions) Automated glycohemoglobin analyzer hlc 723g8, by Tosoh (1 mentions)

3 protocols using c501 instrument

Comprehensive Renal Function Analysis

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Blood samples were collected and centrifuged at 10,000 rpm for 10 min at room temperature (22 °C), and sera were collected and stored at −80 °C for subsequent measurements of renal functions. Serum creatine, blood urea nitrogen and urea levels were measured with the Roche (Basel, Switzerland) C501 instrument, photometrically with the instruction kits, according to the manufacturer’s protocol.

Gunebakan E., Yalcin E., Cikler Dulger E., Yigitbasi A., Ates N., Caglayan A., Beker M.C., Sahin K., Korkaya H, & Kilic E. (2020). Short-Term Diet Restriction but Not Alternate Day Fasting Prevents Cisplatin-Induced Nephrotoxicity in Mice. Biomedicines, 8(2), 23.

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Comprehensive Cardiometabolic Risk Assessment

Cited 2 times

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Participant age, sex, race, past medical history, and smoking status were obtained by questionnaire at the baseline visit. Blood pressure was measured three times after a 5-minute seated rest using an automated BP device (Model 907; Omron Healthcare), and the mean value was used. Body mass index was calculated as weight in kilograms divided by height in meters squared. Serum PTH was measured using an intact PTH immunoassay (e411 analyzer; Roche, Indianapolis, IN), with an interassay coefficient of variation of 4.9% at 35.1 pg/mL and 2.5% at 210.4 pg/mL, with an analytic measurement range of 1.2–5000 pg/mL.³¹ Fasting serum cholesterol, high density lipoprotein (HDL) cholesterol, creatinine, urine albumin, and urine creatinine were measured at the Central Laboratory on a Roche c501 instrument.^{32 (link)} The CKD Epidemiology Collaboration combined creatinine and cystatin C equation^{23 (link)} was used to estimate GFR.

Jovanovich A., Ginsberg C., You Z., Katz R., Ambrosius W.T., Berlowitz D., Cheung A.K., Cho M., Lee A.K., Punzi H., Rehman S., Roumie C., Supiano M.A., Wright C.B., Shlipak M., Ix J.H, & Chonchol M. (2020). FGF23, Frailty, and Falls in SPRINT: FGF23, Frailty, and Falls. Journal of the American Geriatrics Society, 69(2), 467-473.

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Diagnostic Criteria for Type 2 Diabetes

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FPG was measured by the hexokinase method using a Roche Modular P chemistry analyzer (2013–2014) or a Roche Cobas modular C analyzer (2015–2016) (Roche, Basel, Switzerland). HbA1c was measured using a Tosoh Automated Glycohemoglobin Analyzer HLC-723G8 (2013–2016). Insulin was measured by insulin radioimmunoassay. OGTT was measured by the Roche C501 instrument (2013–2014) or Roche C311(2015–2016). T2D was defined according to the harmonized definition as the presence of at least one of the following: (1) FPG ≥ 7.0 mmol/L (126 mg/dL); (2) HbA1c ≥ 6.5% (48 mmol/mol); (3) oral glucose tolerance test (OGTT) ≥200 mg/dL (11.1 mmol/L); (4) current use of medication to treat T2D; and/or (5) self-reported diabetes or sugar diabetes [13 (link)].

Yang J., Chen E., Choi C., Chan K., Yang Q., Rana J., Yang B., Huang C., Yang A, & Lo K. (2022). Cross-Sectional Association of Blood Selenium with Glycemic Biomarkers among U.S. Adults with Normoglycemia in the National Health and Nutrition Examination Survey 2013–2016. Nutrients, 14(19), 3972.

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