Geistlich bio oss collagen

Manufactured by Geistlich Pharma

Sourced in Switzerland

Geistlich Bio-Oss® Collagen is a xenograft bone substitute material composed of natural bovine bone mineral and collagen. It is designed to be used as a bone grafting material in dental procedures.

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Lab products found in correlation

Geistlich mucograft seal, by Geistlich Pharma (2 mentions) Geistlich bio gide, by Geistlich Pharma (1 mentions)

Spelling variants of this product

Bio-Oss (60 citations) Bio-Oss® Collagen (13 citations) Geistlich Bio‐Oss (9 citations)

3 protocols using geistlich bio oss collagen

Alveolar Ridge Preservation Techniques Comparison

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The study protocol was approved by the medical ethical committee, the central committee on human subjects (MEC‐2015‐016; NL49965.078.14) and registered in the Dutch trial register (NL6497). This research was conducted according the principles of the Declaration of Helsinki. The CONSORT statement was used for reporting (Moher et al., 2010). The study was designed as a randomized controlled clinical trial with patients being randomly allocated to one of two ARP techniques or a negative control group:
CM‐group: Demineralized bovine bone mineral with added 10% collagen (Geistlich Bio‐Oss^® Collagen, Geistlich Pharma: DBBM‐C), and covered with a collagen matrix (Geistlich Mucograft^® Seal, Geistlich Pharma: CM).
PG‐group: Demineralized bovine bone mineral with added 10% collagen (DBBM‐C) covered with an autogenous soft tissue “punch” graft harvested from the palate (PG).
Control: Spontaneous healing.

Jonker B.P., Gil A., Naenni N., Jung R.E., Wolvius E.B, & Pijpe J. (2020). Soft tissue contour and radiographic evaluation of ridge preservation in early implant placement: A randomized controlled clinical trial. Clinical Oral Implants Research, 32(1), 123-133.

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Bone Regeneration after Tooth Extraction

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The study was designed as a RCT. The study protocol was approved by the medical ethical committee, the central committee on human subjects (MEC‐2015–016; NL49965.078.14) and registered in the Dutch trial register (NL6497). This research was conducted according to the principles of the Declaration of Helsinki. The CONSORT statement was used for reporting (Moher et al., 2010 (link)).
Study design with inclusion and exclusion criteria, together with the results of the soft tissue contour and radiographic evaluation at implant placement, has been previously reported in detail (Jonker et al., 2021 (link)). In brief, after tooth extraction patients were randomly allocated to one of the following treatment modalities:

CM: Demineralized bovine bone mineral with 10% collagen (DBBM‐C, Geistlich Bio‐Oss® Collagen, Geistlich Pharma) and covered with a collagen matrix (CM, Geistlich Mucograft® Seal, Geistlich Pharma).

PG: DBBM‐C covered with an autogenous soft tissue “punch” graft (PG) harvested from the palate.

Control: Spontaneous healing.

Jonker B.P., Strauss F.J., Naenni N., Jung R.E., Wolvius E.B, & Pijpe J. (2021). Early implant placement with or without alveolar ridge preservation in single tooth gaps renders similar esthetic, clinical and patient‐reported outcome measures: One‐year results of a randomized clinical trial. Clinical Oral Implants Research, 32(9), 1041-1051.

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Ridge Preservation with Bovine Bone and Collagen

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An experienced oral surgeon did all the extractions and alveolar ridge preservations. Extractions were performed under local anesthesia. Periotomes and elevators were used with great care to preserve the buccal bone plate and the surrounding soft and hard tissues. When it was necessary, the teeth were sectioned by a handpiece with diamond burs. No flap was elevated. After tooth extraction, the sockets were carefully debrided to remove all soft tissue remnants. Thereafter, the extraction sockets were randomly assigned to the following two treatment modalities: i) Test group: the sockets were completely filled with deproteinized bovine bone mineral with 10% collagen (DBBM-C; Geistlich Bio-Oss ® Collagen, Geistlich Pharma AG, Wolhusen, Switzerland), then covered with a native bilayer collagen membrane (NBCM; Geistlich Bio-Gide ® , Geistlich Pharma AG, Wolhusen, Switzerland). The membrane was shaped in a way to overlap the margins of the extraction sockets by 2-3mm and placed slightly underneath the marginal mucosa. Subsequently, a cross suture was performed to keep the membrane in place.
ii) Control group: the sockets healed spontaneously without any graft materials and with no sutures.
All the patients were instructed to rinse with 0.12% chlorhexidine for 1 minute, twice a day, for ten days. The sutures of the test site were removed 7-10 days after extraction.

Jung R.E., Sapata V.M., Hämmerle C.H.F., Wu H., Hu X.L, & Lin Y. (2018). Combined use of xenogeneic bone substitute material covered with a native bilayer collagen membrane for alveolar ridge preservation: A randomized controlled clinical trial. Clinical oral implants research, 29(5).

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