The SPECT/CT system (Precedence 6; Philips) consisted of a variable-angle dual-detector with low-energy high-resolution collimators and a multislice spiral CT component optimized for rapid rotation. SPECT/CT imaging was conducted at 6 h after injection of 131I-rhein or 131I-Hyp (as a positive control agent), MI model rats and sham operation rats were anaesthetized with intraperitoneal injection of 10% chloral hydrate. The SPECT acquisition (128 × 128 matrix, 30 frames) was performed using 6° angular steps in a 25-s time frame. For CT (120 kV, 240 mA, 0.75 s/r), 1 mm slices were obtained. After reconstruction, SPECT images were corrected for attenuation and scatter. Both SPECT and CT axial 1-mm slices were generated using an Astonish bone application package and were transferred to a picture archiving and communication systems after generation of DICOM files. SPECT/CT images were fused using the Syntegra software.
Precedence 6
Manufactured by Philips
Sourced in United States
Precedence 6 is a lab equipment product from Philips. It is designed for routine laboratory tasks. The core function of Precedence 6 is to provide consistent and reliable performance in a laboratory setting.
Automatically generated - may contain errors
Lab products found in correlation
3 protocols using precedence 6
1
SPECT/CT Imaging of Radioiodinated Compounds in MI Rats
2
Comparison of State-of-the-Art SPECT/CT Systems
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Data were acquired on five state-of-the-art SPECT/CT systems from three manufacturers: a Discovery NM/CT 670 Pro (GE Healthcare, Milwaukee, USA), a Precedence 6 (Philips Healthcare, Best, The Netherlands), a Symbia Intevo 6, and two Symbia T16’s (Siemens Healthineers, Erlangen, Germany) (Table 1 ).
Characteristics of all used SPECT/CT systems with LEHR collimator
| System | Discovery NM/CT 670 Pro | Precedence 6 | Symbia Intevo 6 | Symbia T16 |
|---|---|---|---|---|
| Detector crystal | 3/8” NaI | 3/8” NaI | 3/8” NaI | 3/8” NaI |
| PMT* | 59 | 55 | 59 | 59 |
| FOV* | 40 × 54 cm | 38.1 × 50.8 cm | 38.7 × 53.3 cm | 38.7 × 53.3 cm |
| Hole shape | Hexagonal | Hexagonal | Hexagonal | Hexagonal |
| Number of holes (× 1000) | Not specified | 86.4 | 148 | 148 |
| Collimator hole diameter | 1.50 mm | 1.40 mm | 1.11 mm | 1.11 mm |
| Hole length | 35 mm | 32.8 mm | 24.05 mm | 24.05 mm |
| Septal thickness | 0.2 mm | 0.152 mm | 0.16 mm | 0.16 mm |
| Sensitivity for 99mTc @ 10 cm | 72 cps/MBq | 66 cps/MBq | 91 cps/MBq | 91 cps/MBq |
| Septal penetration @ 140 keV | 0.3% | 1.3% | 1.5% | 1.5% |
| Planar resolution† | 7.4 mm | 7.4 mm | 7.5 mm | 7.5 mm |
| SPECT central resolution† | 6.4 mm | 4.4 mm | 4.4 mm | 4.4 mm |
| SPECT peripheral radial resolution† | 5.7 mm | 4.2 mm | 4.0 mm | 4.0 mm |
| SPECT peripheral tangential resolution† | 5.1 mm | 4.3 mm | 3.9 mm | 3.9 mm |
* (C)FOV (center) field of view, PMT photomultiplier tube
† Spatial resolution without scatter (LEHR collimator at 10 cm, (full width at half maximum (FWHM) in CFOV [mm], 3/8” crystal)
3
Noninvasive Cardiac Imaging in Myocardial Infarction
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Rats with MI or sham operation were anesthetized by intraperitoneal injection of 10 % chloral hydrate and placed in supine position. SPECT/CT imaging was performed at 4 h after intravenous administration of 7.4 MBq of [ 131 I]HD or [ 131 I]Hyp. The SPECT/CT system (Philips Precedence 6; Philips, Eindhoven, The Netherlands) consisted of a variable angle dual detector equipped with pinhole collimators and a multislice spiral CT component. Images were acquired by the following acquisition parameters: static image matrix size 128 × 128, continuous acquisition 30 frames × 25 s/ frame, and CT (120 kV, 240 mA). SPECT/CT images were fused using Syntegra software.
After the scan of SPECT/CT, rats were immediately sacrificed and organs of interest were collected, weighed, and counted for radioactivity as described above. The hearts isolated from rats with MI were rinsed with saline and cut into slices of 2 mm in the axial plane. After incubation in 2 % triphenyltetrazolium chloride (TTC) solution at 37 °C for 15 min, the TTC-stained slices were digitally photographed and then cut into 30-μm slices for autoradiography studies as described above.
After the scan of SPECT/CT, rats were immediately sacrificed and organs of interest were collected, weighed, and counted for radioactivity as described above. The hearts isolated from rats with MI were rinsed with saline and cut into slices of 2 mm in the axial plane. After incubation in 2 % triphenyltetrazolium chloride (TTC) solution at 37 °C for 15 min, the TTC-stained slices were digitally photographed and then cut into 30-μm slices for autoradiography studies as described above.
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