Tranylcypromine

Manufactured by Enzo Life Sciences

Sourced in United States

Tranylcypromine is a chemical compound used in research and scientific applications. It is a monoamine oxidase inhibitor (MAOI) that functions by inhibiting the enzyme monoamine oxidase, which is responsible for the breakdown of certain neurotransmitters. The specific core function of Tranylcypromine is to serve as a research tool for studying monoamine oxidase and related biological processes.

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Lab products found in correlation

4 protocols using tranylcypromine

Antibodies and Reagents for Cell Analysis

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Antibodies to YY1AP1 (HPA006986) from Sigma; antibody to EpCAM (MAB960) from R&D Systems; anti-DDK monoclonal antibody (TA50011-100) from Origen; antibody to p53 from Santa Cruz Biotechnology (sc-126); antibodies to TCF4 (#2953), E-Cadherin (#5296), AFP (#2137), cleaved caspase 3 (Asp175, #9961), c-Myc (#5605), Sox2 (#3579), β-catenin (#8480), Histone H2B (#12364), ub-Histone H2B (#5546), Methyl-Histone H3 (#9847) and Acetyl-Histone H3 (#9933) antibody sample kits, Tri-Mehyl-Histone H3 (Lys4) (#9751) and Tri-Methyl-Histone H3 (Lys27) (#9733) were from Cell Signaling Technology. Tet-system approved FBS and Doxycycline were from Clontech Laboratories. Caspase inhibitor Z-VAD was from Calbiochem. Daminozide was purchased from Sigma. Tranylcypromine and 2,4-PDCA were purchased from ENZO Life Sciences.

Zhao X., Parpart S., Takai A., Roessler S., Budhu A., Yu Z., Blank M., Zhang Y.E., Jia H.L., Ye Q.H., Qin L.X., Tang Z.Y., Thorgeirsson S.S, & Wang X.W. (2015). Integrative Genomics Identifies YY1AP1 as an Oncogenic Driver in EpCAM+ AFP+ Hepatocellular Carcinoma. Oncogene, 34(39), 5095-5104.

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Compound Validation in Cell Culture

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Lovastatin (Enzo Life Sciences), Tranylcypromine (Enzo Life Sciences), Chloroquine Phosphate (CQ, Enzo Life Sciences), Acetylsalicylic Acid (AA, Sigma-Aldrich), Sulindac (Enzo Life Sciences), Mycophenolate Mofetil (MMF, Enzo Life Sciences), and Amifostine (Enzo Life Sciences) were prepared for validation as a stock solution in DMSO or H₂O and dilutions were produced to obtain working concentrations in cell culture medium.

Zanni E.D., Bianchi G., Ravazzolo R., Raffaghello L., Ceccherini I, & Bachetti T. (2017). Targeting of PHOX2B expression allows the identification of drugs effective in counteracting neuroblastoma cell growth. Oncotarget, 8(42), 72133-72146.

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Pharmacological Excitotoxic Model in Brain

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(RS)-(Tetrazol-5-yl)glycine (5 μM, TZG; Tocris Bioscience, Ellisville, MO, USA), a potent N-Methyl-D-aspartate (NMDA) agonist, was dissolved in phosphate-buffered saline (PBS) (pH 7.4; Thermo Fisher Scientific, Waltham, MA, USA) to induce pharmacological excitotoxic lesions in the brain. NS-398 (2 mg/kg; Cayman Chemical Company, Ann Arbor, MI, USA) and MRE-269 (1 mg/kg; Cayman Chemical Company) were dissolved in dimethyl sulfoxide before being further diluted in PBS. Tranylcypromine (10 mg/kg; Enzo Life Sciences Inc., Farmingdale, NY, USA) was dissolved in PBS (pH 7.4). Antibodies used for immunohistochemistry were rabbit anti-mouse PGI₂ synthase (PGIS) (Abcam, Cambridge, MA, USA), rat anti-mouse CD45 (BD Biosciences, San Jose, CA, USA), biotinylated anti-mouse Ly6G (BD Biosciences), and rat anti-mouse F4/80 (ABD Serotec, Raleigh, NC, USA). Antibodies used for flow cytometry were fluorescein isothiocyanate-conjugated anti-Ly6G and peridinin chlorophyll protein-conjugated anti-Gr1 (BD Biosciences).

An Y., Belevych N., Wang Y., Zhang H., Nasse J.S., Herschman H., Chen Q., Tarr A., Liu X, & Quan N. (2014). Prostacyclin mediates endothelial COX-2-dependent neuroprotective effects during excitotoxic brain injury. Journal of Inflammation Research, 7, 57-67.

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Antibodies and Reagents for Cell Analysis

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