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Bafilomycin b1

Manufactured by Merck Group
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Bafilomycin B1 is a potent and selective inhibitor of vacuolar-type H+-ATPase (V-ATPase). It is a macrolide antibiotic that is commonly used as a research tool to study the role of V-ATPase in various cellular processes.

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Lab products found in correlation

Penicillin streptomycin, by Thermo Fisher Scientific (1 mentions) Dulbecco modified eagle medium (dmem), by Thermo Fisher Scientific (1 mentions) Fetal calf serum (fcs), by Thermo Fisher Scientific (1 mentions) Chloroquine, by Merck Group (1 mentions) Spautin 1, by Merck Group (1 mentions) Wortmannin, by Merck Group (1 mentions) Oxaliplatin, by Abcam (1 mentions) Rapamycin, by Pfizer (1 mentions)

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Bafilomycin (161 citations)

2 protocols using bafilomycin b1

1

Amitriptyline and Autophagy Modulation

Cited 1 time
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The MVEC line EOMA was purchased from ATCC and cultured as described [26 (link)]. In brief, MVECs were maintained in DMEM (Thermo, USA) supplemented with 10% FCS (Thermo, USA) and 1% penicillin/streptomycin (Thermo, USA), and incubated at 37°C and 5%CO2. Cells were treated with indicated dose of amitriptyline, 10 nM bafilomycin B1 (Sigma, MO, USA), 5 μM chloroquine (Sigma, MO, USA) or 10 μM spautin-1 (Sigma, MO, USA) for 6 hr.
Guan Y., Li X., Umetani M., Boini K.M., Li P.L, & Zhang Y. (2018). Tricyclic antidepressant amitriptyline inhibits autophagic flux and prevents tube formation in vascular endothelial cells. Basic & clinical pharmacology & toxicology, 124(4), 370-384.
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2

Cytotoxic Agents Protocol

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Indomethacin (I7378), chloroquine (C6628), bafilomycin B1 (11707), and wortmannin (W1628) were obtained from Sigma-Aldrich. Oxaliplatin (ab141054) was obtained from Abcam. Rapamycin was kindly provided by Pfizer.
Vallecillo-Hernández J., Barrachina M.D., Ortiz-Masiá D., Coll S., Esplugues J.V., Calatayud S, & Hernández C. (2018). Indomethacin Disrupts Autophagic Flux by Inducing Lysosomal Dysfunction in Gastric Cancer Cells and Increases Their Sensitivity to Cytotoxic Drugs. Scientific Reports, 8, 3593.
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