Purelab classic uvf

Manufactured by Elga LabWater

Sourced in United Kingdom

The Purelab Classic UVF is a water purification system designed to produce ultra-pure water for laboratory applications. It utilizes a combination of filtration, ion-exchange, and UV treatment to remove impurities and ensure the highest quality of water.

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Lab products found in correlation

Whatman, by Cytiva (3 mentions) Lc ms grade acetonitrile, by Thermo Fisher Scientific (2 mentions) Methanol, by Avantor (2 mentions) Formic acid, by Merck Group (2 mentions) Hexobarbital, by Merck Group (1 mentions) Efavirenz, by LGC (1 mentions) Nevirapine, by LGC (1 mentions)

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Purelab Classic (10 citations)

3 protocols using purelab classic uvf

Quantitative Bioanalysis of ARV Drugs

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Lamivudine (3TC) and internal standard (IS) lamivudine-¹⁵N₂,¹³C (3TC-IS), emtricitabine (FTC) and emtricitabine-¹³C,¹⁵N₂ (FTC-IS) and tenofovir (TFV) were obtained from TRC Canada (North York, Ontario). LC–MS grade acetonitrile was obtained from Fisher Scientific (Loughborough, Leicestershire, UK), methanol from VWR International (Lutterworth, Leicestershire, UK), formic acid from Sigma-Aldrich (Gillingham, Dorset, UK) and water was produced from an Elga Option 4 water purifier (Elga LabWater, High Wycombe, Buckinghamshire, UK) and was further purified to 18.2 MΩ with a Purelab Classic UVF (Elga LabWater, High Wycombe, Buckinghamshire, UK). Whatman 903 Protein Saver cards were obtained from Scientific Laboratory Supplies (Hessle, East Yorkshire, UK). Blank whole blood was collected into EDTA tubes from drug-free healthy volunteers and blank BM samples were obtained from the Wirral Mothers’ Milk Bank, Clatterbridge Hospital, Wirral, UK; the University of Liverpool Research Ethics Committee approved these processes.

Waitt C., Diliiy Penchala S., Olagunju A., Amara A., Else L., Lamorde M, & Khoo S. (2017). Development, validation and clinical application of a method for the simultaneous quantification of lamivudine, emtricitabine and tenofovir in dried blood and dried breast milk spots using LC–MS/MS. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 1060, 300-307.

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Quantification of Efavirenz in Breast Milk

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Reference standard of efavirenz was obtained from Toronto Research Chemicals
Inc. (North York, ON, Canada) and hexobarbital, used as an internal standard (IS),
was obtained from Sigma-Aldrich (Gillingham, Dorset, UK). LC-MS grade acetonitrile
was obtained from Fisher scientific (Loughborough, Leicestershire, UK), methanol
from VWR International (Lutterworth, Leicestershire, UK) and water was produced from
an Elga Option 4 water purifier (Elga Labwater, High Wycombe, Buckinghamshire, UK)
and was further purified to 18.2 MΩ with a Purelab Classic UVF (Elga
LabWater, High Wycombe, Buckinghamshire, UK). Whatman 903 Protein Saver cards were
obtained from Scientific Laboratory Supplies (Hessle, East Yorkshire, UK). Blank
breast milk samples were obtained (with ethics approval) from Wirral Mothers’
Milk Bank, Clatterbridge Hospital, Wirral, UK and whole blood was obtained from
drug-free healthy volunteers.

Olagunju A., Bolaji O.O., Amara A., Waitt C., Else L., Soyinka J., Adeagbo B., Adejuyigbe E., Siccardi M., Back D., Owen A, & Khoo S. (2014). Development, validation and clinical application of a novel method for the quantification of efavirenz in dried breast milk spots using LC-MS/MS. The Journal of antimicrobial chemotherapy, 70(2), 555-561.

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Quantitative Analysis of Nevirapine in Whole Blood and Breast Milk

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Nevirapine and Nevirapine-d5 (internal standard, IS) reference standards were
obtained from Toronto Research Chemicals Inc. (North York, ON, Canada). LC-MS grade
acetonitrile was obtained from Fisher Scientific (Loughborough, Leicestershire, UK),
methanol from VWR International (Lutterworth, Leicestershire, UK), formic acid from
Sigma-Aldrich (Gillingham, Dorset, UK) and water was produced from an Elga Option 4
water purifier (Elga Labwater, High Wycombe, Buckinghamshire, UK) and was further
purified to 18.2 MΩ with a Purelab Classic UVF (Elga LabWater, High Wycombe,
Buckinghamshire, UK). Whatman 903 Protein Saver cards were obtained from Scientific
Laboratory Supplies (Hessle, East Yorkshire, UK). Blank whole blood was obtained
from drug-free healthy volunteers and blank breast milk samples were obtained (with
ethical approval) from Wirral Mothers’ Milk Bank, Clatterbridge Hospital,
Wirral, UK.

Olagunju A., Amara A., Waitt C., Else L., Penchala S.D., Bolaji O., Soyinka J., Siccardi M., Back D., Owen A, & Khoo S. (2015). Validation and clinical application of a method to quantify nevirapine in dried blood spots and dried breast milk spots. The Journal of antimicrobial chemotherapy, 70(10), 2816-2822.

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