Microselectron

All patients were treated with definitive RT consisting of external beam RT (EBRT) and intracavitary brachytherapy (ICBT). EBRT was performed using 10 MV x-rays at 2 Gy per fraction with 5 fractions per week. Whole-pelvic irradiation was performed at a total dose of 50 Gy in 25 fractions with the final 20 or 30 Gy delivered through a 3-cm-wide central shielding, depending on the clinical stage. The pelvic field expanded into the metastatic area in patients with para-aortic lymph node metastases. Patients with lymph node metastases received additional irradiation of 6 to 8 Gy in 3 to 4 fractions. ICBT was performed once per week concurrently with central shielding EBRT. EBRT was skipped on the day of ICBT administration. Three-dimensional image guided brachytherapy was performed on all patients using an ¹⁹²Ir remote afterloading system (microSelectron; Elekta, Stockholm, Sweden). ICBT was performed to cover 90% of the high-risk clinical target volume, at a total dose of 6 Gy per fraction. Bulky and/or asymmetrical tumors were treated with additional interstitial brachytherapy.¹² (link) ICBT was performed 4 times. Concurrent chemotherapy with cisplatin was administered weekly at a dose of 40 mg/m² to 67.0% of patients (45/67).