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Nod ltsz scid il2rγ cnull nsg mice

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The NOD/LtSz-scid/IL2Rγ cnull (NSG) mouse is a severely immunodeficient mouse strain. It lacks functional T cells, B cells, and natural killer cells, making it a useful model for xenograft studies and other applications requiring a highly immunocompromised host.

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Lab products found in correlation

Bromodeoxyuridine (brdu), by Merck Group (2 mentions)

Spelling variants of this product

NSG mice (401 citations) NOD/SCID mice (263 citations) NOD/SCID (81 citations) NOD mice (59 citations) SCID mice (40 citations) NOD/SCID/IL2Rγ−/− (NSG) mice (25 citations) NOD/SCID/IL2Rγ−/− mice (8 citations) NOD/scid/IL2rγ−/− (NSG) (4 citations) NSG (NOD-SCID) mice (2 citations)

2 protocols using nod ltsz scid il2rγ cnull nsg mice

1

Engrafting human AML in NSG mice

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NOD/LtSz-scid/IL2Rγ cnull (NSG) mice were purchased from the Jackson Laboratory (Bar Harbor, ME) and maintained in a breeding colony under specific pathogen-free conditions in the animal care facilities at both institutions. 8-12 week old mice were irradiated with 200-250 cGy from a cesium irradiator immediately prior to transplant. Human AML cells (1-3×106 cells per mouse) or AML-derived ECFCs (1-3×105 cells per mouse) were injected intravenously. Mice were allowed to drink freely for 6 days from water bottles containing 0.8mg/ml Bromodeoxy uridine (BrdU; Sigma), freshly prepared every other day.
Cogle C.R., Goldman D.C., Madlambayan G.J., Leon R.P., Masri A.A., Clark H.A., Asbaghi S.A., Tyner J.W., Dunlap J., Fan G., Kovacsovics T., Liu Q., Meacham A., Hamlin K.L., Hromas R.A., Scott E.W, & Fleming W.H. (2014). Functional Integration of Acute Myeloid Leukemia into the Vascular Niche. Leukemia, 28(10), 1978-1987.
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2

Engrafting human AML in NSG mice

Check if the same lab product or an alternative is used in the 5 most similar protocols
NOD/LtSz-scid/IL2Rγ cnull (NSG) mice were purchased from the Jackson Laboratory (Bar Harbor, ME) and maintained in a breeding colony under specific pathogen-free conditions in the animal care facilities at both institutions. 8-12 week old mice were irradiated with 200-250 cGy from a cesium irradiator immediately prior to transplant. Human AML cells (1-3×106 cells per mouse) or AML-derived ECFCs (1-3×105 cells per mouse) were injected intravenously. Mice were allowed to drink freely for 6 days from water bottles containing 0.8mg/ml Bromodeoxy uridine (BrdU; Sigma), freshly prepared every other day.
Cogle C.R., Goldman D.C., Madlambayan G.J., Leon R.P., Masri A.A., Clark H.A., Asbaghi S.A., Tyner J.W., Dunlap J., Fan G., Kovacsovics T., Liu Q., Meacham A., Hamlin K.L., Hromas R.A., Scott E.W, & Fleming W.H. (2014). Functional Integration of Acute Myeloid Leukemia into the Vascular Niche. Leukemia, 28(10), 1978-1987.
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