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Il1r1 24 link mice

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The IL1R1−/−24 (link) mice are a genetically modified mouse model that lacks the gene for the interleukin-1 receptor type 1 (IL1R1). This receptor is important for mediating the biological effects of the pro-inflammatory cytokine interleukin-1 (IL-1). The IL1R1−/−24 (link) mice can be used in research to study the role of the IL-1 signaling pathway in various biological processes and disease models.

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Il1r1−/− (26 citations) Il1r1−/− mice (21 citations)

2 protocols using il1r1 24 link mice

1

Deletion of A20 in Myeloid Cells

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A20myel-KO mice with a lysosome M-Cre-targeted deletion of A20 in myeloid cells were described2 (link). Nlrp3−/−22 (link) and Casp1−/−23 (link) mice have been described, and were kindly provided by Dr. V. Dixit (Genentech) and Dr. R. Flavell (Yale University). IL1R1−/−24 (link) mice were purchased from Jackson Laboratories and bred in-house. In vivo experiments were controlled with age- and sex-matched littermates. The sample size was chosen so as to validate statistical analyses. Mice were housed in individually ventilated cages and kept under pathogen-free conditions at animal facilities of Ghent University. All animal experiments were conducted with permission of the Ethical committees on laboratory animal welfare of Ghent University.
Walle L.V., Van Opdenbosch N., Jacques P., Fossoul A., Verheugen E., Vogel P., Beyaert R., Elewaut D., Kanneganti T.D., van Loo G, & Lamkanfi M. (2014). Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis. Nature, 512(7512), 69-73.
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2

Deletion of A20 in Myeloid Cells

Check if the same lab product or an alternative is used in the 5 most similar protocols
A20myel-KO mice with a lysosome M-Cre-targeted deletion of A20 in myeloid cells were described2 (link). Nlrp3−/−22 (link) and Casp1−/−23 (link) mice have been described, and were kindly provided by Dr. V. Dixit (Genentech) and Dr. R. Flavell (Yale University). IL1R1−/−24 (link) mice were purchased from Jackson Laboratories and bred in-house. In vivo experiments were controlled with age- and sex-matched littermates. The sample size was chosen so as to validate statistical analyses. Mice were housed in individually ventilated cages and kept under pathogen-free conditions at animal facilities of Ghent University. All animal experiments were conducted with permission of the Ethical committees on laboratory animal welfare of Ghent University.
Walle L.V., Van Opdenbosch N., Jacques P., Fossoul A., Verheugen E., Vogel P., Beyaert R., Elewaut D., Kanneganti T.D., van Loo G, & Lamkanfi M. (2014). Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis. Nature, 512(7512), 69-73.
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