Hpmc k4m

Manufactured by Colorcon

Sourced in United Kingdom, India

HPMC K4M is a type of hydroxypropyl methylcellulose (HPMC) that is commonly used in pharmaceutical and food applications. It is a water-soluble, non-ionic cellulose ether that functions as a binder, thickener, and film-forming agent.

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Lab products found in correlation

Hpmc k15m, by Colorcon (2 mentions) Kollidon sr, by BASF (1 mentions) Sodium dihydrogen phosphate, by Merck Group (1 mentions) Deuterium oxide, by Apollo Scientific (1 mentions) Sodium hydroxide (naoh), by Merck Group (1 mentions) Glacial acetic acid, by Merck Group (1 mentions) Sodium chloride (nacl), by Merck Group (1 mentions) Hydrochloric acid (hcl), by Thermo Fisher Scientific (1 mentions) Hpmc e4m, by Colorcon (1 mentions) Hpmc k 15, by Colorcon (1 mentions) Hpmc k200m, by Colorcon (1 mentions) Microcrystalline cellulose, by FMC Biopolymer (1 mentions) Magnesium stearate, by Loba Chemie (1 mentions) Polyvinylpyrrolidone pvp k30, by Merck Group (1 mentions) Methanol, by SD Fine Chemicals (1 mentions) Acetonitrile, by SD Fine Chemicals (1 mentions) Proloc 15, by Henkel Adhesive Technologies (1 mentions) Hpmc k100m, by Colorcon (1 mentions) Acetonitrile, by Merck Group (1 mentions) Methanol, by Merck Group (1 mentions)

Close spelling variants of this product

Hydroxypropyl methyl cellulose (HPMC) K4M (5 citations) HPMC (Methocel K4M) (2 citations)

13 protocols using hpmc k4m

Sustained-Release Tablet Formulation

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Itopride hydrochloride (ITP) was kindly gifted by Abbott Laboratories (Pakistan) Limited.
Hydroxypropyl methylcellulose (HPMC-K4M, K100M) and ethylcellulose (EC-10 cps) were purchased from Colorcon Limited (Kent, England). Kollidon ® SR was provided by BASF (Ludwigshafen, Germany). Microcrystalline cellulose (MCC, Avicel pH 101) was procured from Dow Chemical Company (USA). Talc was purchased from the BDH Laboratories Suppliers, England. Magnesium stearate was provided by FMC Corporation, USA. All other materials used were analytical grades.

Siraj A., Nasiri M.I., Naqvi S.A.A., Ali T., Yousaf R.I., Sarwar H., & Asghar M.A. (2021). FORMULATION DEVELOPMENT AND EVALUATION OF HIGHLY WATER-SOLUBLE DRUG-LOADED CONTROLLED RELEASE MATRIX TABLETS. Bulletin of Pharmaceutical Sciences Assiut, 44(1), 15-29.

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Pharmaceutical Excipient Characterization

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HPMC-K4M and PVP-Kollidon 30 were kindly donated by Colorcon (UK) and BASF (Germany), respectively. Sodium Taurocholate with 99% purity was purchased from Prodotti chimici e alimentari SPA (Italy). Deuterium oxide with 99% purity was purchased from Apollo Scientific (UK). All reagents and chemical including sodium hydroxide with purity 97%, sodium chloride with purity 99%, sodium dihydrogen phosphate with purity 99% and glacial acetic acid with purity ≥ 99% were purchased from Sigma Aldrich (UK).

Pigliacelli C., Belton P., Wilde P, & Qi S. (2019). Probing the molecular interactions between pharmaceutical polymeric carriers and bile salts in simulated gastrointestinal fluids using NMR spectroscopy. Journal of colloid and interface science, 551.

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Formulation and Evaluation of AZM Ocular Gel

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AZM was procured from M/s
Sun Pharma, Paonta Sahib, India. Carbopol 934P (Lot No. 9003-01-4)
(Loba Chemicals, Mumbai), HPMC K4M (Lot No. 9004-64-2) (Colorcon,
UK), SBE-β-CD (Cydex Pharmaceuticals, USA), edetate disodium
(Lot No. 6381-92-6) (Loba Chemicals, Mumbai), benzalkonium chloride
(Ases Chemicals Works, Jodhpur), citric acid (Ases Chemicals Works,
Jodhpur), disodium hydrogen phosphate (Lot No. 10028-24-7), potassium
dihydrogen orthophosphate (Lot No. 7778-77-0), and sodium hydroxide
(Lot No. 1310-73-2) were purchased from Loba Chemicals, Mumbai. Whatman’s
filter paper-41 (Lot No. WHA1441125) (M/s Whatman Int. Ltd., England), Bacillus subtilis (Cat. No. - MCC 2010; National
Centre for Microbial Resource, Pune, India), and purified water (in house laboratory) were used as is for the experiments.
Albino rabbits for testing were obtained from the central animal house,
Lachoo Memorial College of Science and Technology (Autonomous), Jodhpur,
Rajasthan.

Thakur A., Jain S., Pant A., Sharma A., Kumar R., Singla N., Suttee A., Kumar S., Barnwal R.P., Katare O.P, & Singh G. (2022). Cyclodextrin Derivative Enhances the Ophthalmic Delivery of Poorly Soluble Azithromycin. ACS Omega, 7(27), 23050-23060.

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Formulation and Evaluation of Nizatidine Tablets

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Strides Pharma Science Limited (Formerly Strides Shasun Limited, Bangalore, India) provided nizatidine as a gift sample. Colorcon UK generously gifted HPMC K4M, HPMC E4M, HPMC K15 and HPMC K200M. All other tableting excipient including carbopol 934P, sodium bicarbonate, magnesium stearate and lactose were of research grade and were sourced from BDH Laboratory (UK). Hydrochloric acid (37%) was sourced from Fisher Scientific (UK). All the experiments were performed using de-ionised water that was prepared at in-house facility.

Shahzad Y., Ibrar N., Hussain T., Yousaf A.M., Khan I.U., & Rizvi S.A.A. (2021). Relevancy of Nizatidine’s Release from Floating Tablets with Viscosity of Various Cellulose Ethers. Sci, 3(2), 22-22.

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Bioavailability Study of Paroxetine Hydrochloride Hemihydrate

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PHH was purchased from Zhejiang Linhai Jinqiao Chemical Co., Ltd. (Zhejiang, China). HPMC K4M was obtained from Colorcon Co., Ltd. (Shanghai, China). CMC-Na was provided by Guangzhou Qihua Medical Equipment Co., Ltd. (Guangdong, China). Polyvinylpyrrolidone (PVP K30) was purchased from International Specialty Products Inc. (Wayne, NJ, USA). Microcrystalline cellulose (MCC) and magnesium stearate were purchased from Huzhou Pharmaceuticals Co., Ltd. (Zhejiang, China). Lactose (Granulac 200) was obtained from Molkerei Meggle Wasserburg GmbH & Co. Kg. (Wasserburg, Germany). Methacrylic resin (Eudragit L30D-55) was received from Evonik Röhm GmbH (Darmstadt, Germany). The reference substance of PHH, desfluoroparoxetine and N-methyl-paroxetine were supplied by the National Institutes for Food and Drug Control (Beijing, China). PAXIL^® CR was purchased from GlaxoSmithKline plc. (Brentford, UK) and applied as the reference formulation. Clozapine was obtained from Shandong Qilu Pharmaceuticals Co., Ltd. (Shandong, China). Methanol, acetonitrile and n-hexane were of chromatographic grade. All other chemicals used were of analytical grade. Beagle dogs (male, 4-year old) were purchased from Kangda Experimental Animal Technology Co., Ltd. (Guangdong, China). Dogs were maintained in separate cages and food and water were provided ad libitum.

Yang Y., Huang Z., Zhang X., Li J., Huang Y., Chen W., Pan X, & Wu C. (2018). Development of Paroxetine Hydrochloride Single Layer Controlled-Release Tablets Based on 32 Factorial Design. Pharmaceutics, 10(4), 243.

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Formulation and evaluation of capecitabine tablets

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Capecitabine was obtained as a gift sample from Divi's Laboratories, Hyderabad, India. HPMC K4M, HPMC K15M and HPMC LVCR 100, partially pre gelatinized starch were obtained from Colorcon Ltd, India. Sodium bicarbonate and calcium carbonate were purchased from CDH Pvt Ltd, India. Micro crystalline cellulose was obtained from FMC biopolymer, USA and spray dried lactose with maize starch was obtained from Roquette Pharma, France. Dicalcium phosphate, talc and magnesium stearate were purchased from Loba Chemie, India. All other reagents of analytical grade and all the solvents in HPLC are of HPLC grade.

Shaik S., Maddela S., & Nalluri B.N. (2020). Development of Capecitabine Floating Tablet Dosage Forms for Treating Stomach Cancer. Journal of Drug Delivery and Therapeutics, 10(3-s), 199-205.

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Venlafaxine HCl Sustained-Release Formulation

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Venlafaxine HCl was generously gifted by Ranbaxy Labs. Ltd., Gurgaon, India. Various excipients like sodium alginate, HPMC (K4M, K15M, K100M) were provided by Colorcon, Goa, India, whereas CaCl₂, carbopol 974P and chitosan provided by Evonik, Mumbai, India. While all other chemicals and reagents like sodium hydroxide, potassium dihydrogen phosphate used was of analytical reagent grade. Deionized distilled water was used throughout the experimental procedure.

Swain S., Behera A., Dinda S.C., Patra C.N., Jammula S., Beg S, & Rao M.E. (2014). Formulation Design, Optimization and Pharmacodynamic Evaluation of Sustained Release Mucoadhesive Microcapsules of Venlafaxine HCl. Indian Journal of Pharmaceutical Sciences, 76(4), 354-363.

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Isolation and Characterization of Crocin Markers

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Reference marker
compounds, trans-4-GG-crocin (also named as crocin-1), trans-3-Gg-crocin, trans-2-gg-crocin, and cis-4-GG-crocin, were isolated from the IIIM-141 extract
using semipreparative HPLC. These markers were used for standardization
of extracts by HPLC. Acetonitrile (SD Fine Chemicals), methanol (SD
Fine Chemicals), formic acid (Rankem), and ethanol were used in the
semipreparative isolation of markers by HPLC. Polyvinylpyrrolidone
(PVP)-K30 and ethyl cellulose 10 cps were procured from Sigma-Aldrich.
HPMC-K4M and HPMC-K15M were obtained as gift samples from Colorcon
Asia Pvt. Ltd. (Goa). Eudragit RS100 was received from Evonik Industries
as a gift sample. Empty hard gelatin capsules were obtained from Natural
Capsules Ltd. Bengaluru, India as a gift sample.

Bharate S.S., Kumar V., Singh G., Singh A., Gupta M., Singh D., Kumar A., Vishwakarma R.A, & Bharate S.B. (2018). Preclinical Development of Crocus sativus-Based Botanical Lead IIIM-141 for Alzheimer’s Disease: Chemical Standardization, Efficacy, Formulation Development, Pharmacokinetics, and Safety Pharmacology. ACS Omega, 3(8), 9572-9585.

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Topical Ophthalmic Formulation Development

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AZM was procured ex gratis from Sun Pharma, Poanta Sahib,India. Carbopol 934P (Loba Chemicals, Mumbai), HPMC K4M (Colorcon), SBE-β-CD (Cydex Pharmaceuticals,), Edetate disodium (Loba Chemicals, Mumbai), Benzalkonium chloride (Ases chemicals works, Jodhpur), Citric acid (Ases chemicals works, Jodhpur), Disodium hydrogen phosphate (Loba Chemicals, Mumbai), Whatman's filter paper-41 (Whatmann Int. Ltd, England), Purified water (In house Laboratory) were used as it is for the experiments. Albino rabbits were obtained from the central animal house, Lachoo Memorial College of Science and Technology (Autonomous), Jodhpur, Rajasthan for the testing.

Thakur A., Jain S., Pant A., Sharma A., Kumar R., Sharma G., Singla N., Suttee A., Kumar S., Barnwal R.P., Katare O.P., & Singh G. (2020). CYCLODEXTRIN DERIVATIVE ENHANCES THE OPHTHALMIC DELIVERY OF POORLY SOLUBLE AZITHROMYCIN.

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Rizatriptan Benzoate Formulation Optimization

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Rizatriptan benzoate (Emcure Pharmaceuticals, Ahmedabad, India), Proloc 15 (Henkel Corporation, Rocky Hill, CT, USA), HPMC F4M, HPMC K4M and HPMC K100M (Colorcon Limited, Goa, India) were obtained as a gift. Tween 80, propylene glycol and polyethylene glycol 200 (PEG 200) were procured (Sigma Aldrich, St. Louis, MO, USA). All other chemicals and reagents utilized in this research were commercially obtained from local traders with the highest quality.

Nair A.B., Shah J., Jacob S., Al-Dhubiab B.E., Patel V., Sreeharsha N, & Shinu P. (2021). Development of Mucoadhesive Buccal Film for Rizatriptan: In Vitro and In Vivo Evaluation. Pharmaceutics, 13(5), 728.

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