The hardness measurements were performed using an SBT apparatus (Erweka, Germany) at room temperature (22 ± 0.5 °C) to evaluate the mechanical resistance of the suppositories to crushing, i.e., to determine the mass at which the suppository breaks or crushes at room temperature [21 (link)]. One suppository of each dosage per formula was placed between two jaws applying a mass of 600 g, and a mass of 200 g was added to the rod attached to the upper jaw every minute until the suppository was crushed. The time taken to crush each tested suppository was recorded. This test was adapted from monograph 2.9.24 of the Ph. Eur. [22 ].
Sbt apparatus
Manufactured by Erweka
Sourced in Germany
The SBT apparatus is a laboratory equipment designed for the disintegration testing of solid dosage forms, such as tablets and capsules. It operates based on the disintegration test method specified in pharmacopoeial regulations. The apparatus provides a standardized environment for the test, ensuring consistent and reproducible results.
Automatically generated - may contain errors
Lab products found in correlation
2 protocols using sbt apparatus
1
Evaluation of Suppository Hardness
2
Uniformity, Softening, and Disintegration of Suppositories
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
The uniformity of mass of single-dose preparation test was carried out as follows: twenty suppositories were individually weighted (Mettler AT201 FACT Switzerland) from each formula. Average mass and standard deviation (SD) were calculated.
The softening time determination of lipophilic suppositories test was conducted using apparatus for measuring the softening time of suppositories (n = 3).
The disintegration of suppositories test was performed in water maintained at 37 °C ± 0.5 °C using ST30 apparatus (Erweka, Germany) (n = 3).
The resistance to rupture of suppositories test was carried out on 10 suppositories using SBT apparatus (Erweka, Germany) at room temperature (22 °C ± 0.5 °C). Results of above tests are shown inTable 2 .
The softening time determination of lipophilic suppositories test was conducted using apparatus for measuring the softening time of suppositories (n = 3).
The disintegration of suppositories test was performed in water maintained at 37 °C ± 0.5 °C using ST30 apparatus (Erweka, Germany) (n = 3).
The resistance to rupture of suppositories test was carried out on 10 suppositories using SBT apparatus (Erweka, Germany) at room temperature (22 °C ± 0.5 °C). Results of above tests are shown in
About PubCompare
Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.
We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.
However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.
Ready to get started?
Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required
Revolutionizing how scientists
search and build protocols!