Poly ethylene glycol methyl ether mpeg

PES was provided by JiDa High Performance Materials Co., Ltd. (Jilin, China) and dried before using. Fluorocarbon surfactant (HO(CH₂CH₂O)_x(CF₂CF₂)_yF, fPEG, Mn = 950, 95%) was purchased from DuPont (Shanghai, China). Poly(ethylene glycol) methyl ether (mPEG, M_n = 1000, 98%) was purchased from Sigma-Aldrich (Shanghai, China) and used as received. 2-hydroxyethyl methacrylate (HEMA, 98%), bromoisobutyryl bromide (BiBB, 98%), L-ascorbic acid (AsAc, 99%), copper bromide (CuBr₂, 99%), N,N,N′,N″,N″-pentamethyldiethylenetriamine (PMDETA, 99%), succinic anhydride (SA, 99%), 3-aminopropyltrimethoxysilane (APTMS, 99%), triethylamine (TEA, 99%), 4-Dimethylaminopyridine (DMAP, 99%), sodium dodecyl sulfate (SDS, 99%), and thionylchloride (SOCl₂, 99%) were purchased from Aladdin (Shanghai, China) and used without further purification. Dichloromethane (CH₂Cl₂), toluene, tetrahydrofuran (THF), dimethylacetamide (DMAc), and 1,4-dioxane were obtained from Aladdin (Shanghai, China) and purified by distillation from sodium hydride.

D,L-lactide (3,6-dimethyl-1,4-dioxane-2,5-dione, 99%) was purchased from Corbion (Netherlands) and recrystallized in butyl acetate before use. Poly(ethylene glycol) methyl ether (mPEG) with a molecular weight of 5000 Da, stannous (II) 2-ethylhexanoate (SnOct₂) were purchased from Sigma-Aldrich and used as received. All organic solvents were of analytical grade and used without further purification. Double distilled water was used for all experiments. Oxaliplatin (trans-R,R-cyclohexane-1,2-diamine)oxalatoplatinum(II)) was synthesized using a procedure described in literature [56 (link)].

Ethylenediamine (EDA, Mw 60.10 Da) and toluene were purchased from Merck (Darmstadt, Germany). Methyl acrylate (MA, Mw 86.09 Da), poly (ethylene glycol) methyl ether (mPEG, Mw: 5 kDa), 4-Nitrophenyl chloroformate (NPC, Mw 201.56 Da), tetrahydrofuran (THF), and diethyl ether were purchased from Sigma-Aldrich (St. Louis, MO, USA). Methanol was supplied by Fisher Scientific (Waltham, MA, USA). Carboplatin (CAR) was received from TCI (Tokyo, Japan). Spectra/Por® Dialysis Membrane (MWCO 3.5 kDa and 12–14 kDa) was purchased from Spectrum Laboratories, Inc. (Rancho Dominguez, CA, USA). All reagents and solvents were used as received without further purification.