In our study, we included all patients with an iatrogenic or post-interventional duodenal leak diagnosed through an endoscopic examination between January 2016 and December 2021. All patients underwent EVT with the EsoSponge® (Aeskulap AG, Melsung, Germany) at our hospitals.
Orbis
ORBIS is a digital radiography system designed for medical imaging applications. It captures high-quality digital X-ray images, which can be used for diagnosis and treatment planning.
36 protocols using orbis
Endoscopic Vacuum Therapy for Duodenal Leaks
In our study, we included all patients with an iatrogenic or post-interventional duodenal leak diagnosed through an endoscopic examination between January 2016 and December 2021. All patients underwent EVT with the EsoSponge® (Aeskulap AG, Melsung, Germany) at our hospitals.
SARS-CoV-2 Infection Rates in Radiotherapy Patients
Clinical data, treatment protocols and virus-related anamnesis were collected from all cancer patients receiving radiotherapy between 13 October 2020 and 11 March 2021. In addition, all SARS-CoV‑2 tests in the stated time period were evaluated. For each test, nasal and pharyngeal respiratory swabs were taken for detecting SARS-CoV‑2 RNA by real-time polymerase chain reaction (RT-PCR). All tests were performed at the Department of Virology, University Hospital Frankfurt.
Test results were documented in the clinical information system ORBIS (Agfa HealthCare) and correlated with individual clinical and anamnestic data at the time of testing, i.e., (i) presence of COVID-19 symptoms and (ii) virus-related anamnesis (see below).
In case of a positive test result, contact tracing was performed and the clinical course of COVID-19 was documented.
Furthermore, SARS-CoV‑2 infection rates in the observation period were assessed by the daily 7‑day incidences within the community of Frankfurt and nationwide.
Evaluating Abdominal Trauma Severity
Retrospective Study of Elective Shoulder Arthroplasty
Exclusion criteria were revision surgery, active inflammation or infection, known inflammatory diseases, neoplasia, liver cirrhosis, and postoperative complications within the three-month follow-up. Patients with elevated preoperative baseline CRP level > 1 mg/dL were also excluded (reference < 0.5 mg/dL).
Retrospective Study of Arthroplasty Outcomes
Demographic, anamnestic and clinical data were collected retrospectively from the hospital’s information technology system (ORBIS, Agfa Healthcare GmbH, Bonn, Germany). Data about the use of allogeneic and autologous blood transfusions were crosschecked using hard copy records. Of the demographic and anamnestic data, we recorded the patient’s age, sex, height and weight as well as the preoperative medication, daily consumption of alcohol or nicotine and comorbidities. Of the preoperative clinical data, we recorded the American Society of Anaesthesiologists (ASA) status and the lab values of the last blood sample before undergoing surgery, including c-reactive protein (mg/dL), haemoglobin concentration (g/dL), haematocrite (%), mean corpuscular volume (MCV) (fl), platelet count (103/µL), creatinine (µmol/L), estimated glomerular filtration rate (eGFR) (mL/min) Quick (%) and partial thromboplastin time (PTT) (sec).
Of the intraoperative data, we collected the type of anaesthesia, the type of surgery, the use of tranexamic acid, duration of surgery, the use of drains and the use of an autologous re-transfusion system (cell saver).
Anonymized Patient Data Analysis
Retrospective Analysis of Nasopharyngeal Carcinoma
The study protocol was reviewed and approved by our local institutional review board and informed consent was given by all participants.
Retrospective Study of Anal SCC
Electronic Clinical Data Extraction
Retrospective Analysis of Esophageal Leaks
Esophageal AL is defined according to the ECCG classification as a full thickness GI defect involving esophagus, anastomosis or staple line irrespective of presentation or method of identification. The leak were further classified as, Type I: local defect requiring no change in therapy or treated medically or with dietary modification; Type II: localized defect requiring interventional but not surgical therapy; Type III: localized defect requiring surgical therapy [20 (link)].
Data were retrieved from our prospectively maintained hospital database “Orbis” (version 08,043,703; Agfa HealthCare N.V., Belgium) and from our prospectively maintained endoscopic database “Clinic WinData” (version 8.06; E&L medical system GmbH, Erlangen, Germany). The following information was collected: demographic and clinical patient characteristics, details of the disease, leak characteristics, time to EVT, duration of EVT, and follow-up treatments.
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