L name

Manufactured by Enzo Life Sciences

Sourced in Germany, Switzerland, United Kingdom

L-NAME is a laboratory reagent used for research purposes. It is a nitric oxide synthase inhibitor that can be used to investigate the role of nitric oxide in various biological processes. The core function of L-NAME is to inhibit the production of nitric oxide in experimental settings.

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Lab products found in correlation

8 bromo cgmp, by Biolog (1 mentions) Deta no, by Enzo Life Sciences (1 mentions) Dea no, by Enzo Life Sciences (1 mentions) 3 isobutyl 1 methyl xanthine (ibmx), by Enzo Life Sciences (1 mentions) Hexadecyltrimethylammonium, by Merck Group (1 mentions) Noradrenaline, by Merck Group (1 mentions) Sodium pyruvate, by Carl Roth (1 mentions) Carbachol, by Merck Group (1 mentions) Orthophosphoric acid, by Avantor (1 mentions) Mgso4, by Avantor (1 mentions) Potassium chloride (kcl), by Avantor (1 mentions) Sodium chloride (nacl), by Avantor (1 mentions) Folin ciocalteu reagent, by Carl Roth (1 mentions) Cacl2, by Avantor (1 mentions) Kh2po4, by Avantor (1 mentions) Ethylene diamine tetraacetic acid (edta), by Carl Roth (1 mentions) Gallic acid, by Merck Group (1 mentions) Quercetin, by Merck Group (1 mentions) Thiobarbituric acid, by Merck Group (1 mentions) D glucose, by Merck Group (1 mentions)

3 protocols using l name

Antibody-based detection of sGC subunits

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Polyclonal antibodies specific for sGCα₁ and sGCβ₁ have been described elsewhere (30). Actin monoclonal antibody (Oncogene Research Products, Boston, USA); collagenase type CLS II (Merck, Netherlands); 8-Bromo-cGMP (BIOLOG, Germany); L-NAME, DETA/NO, DEA/NO, IBMX and GTP (Enzo Life Sciences, Netherlands); BAY 58-2667 was synthesized as described^{75 (link)}. All other chemicals were of the highest purity grade available and obtained from Sigma or Merck (Netherlands). DETA/NO and DEA/NO were dissolved in 10 mM NaOH, BAY 58-2667 and YC-1 in DMSO.

Dao V.T., Elbatreek M.H., Deile M., Nedvetsky P.I., Güldner A., Ibarra-Alvarado C., Gödecke A, & Schmidt H.H. (2020). Non-canonical chemical feedback self-limits nitric oxide-cyclic GMP signaling in health and disease. Scientific Reports, 10, 10012.

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Evaluation of Antioxidant and Vasoactive Compounds

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ISO, hexadecyltrimethylammonium, trichloroacetic acid, carbachol, butylated hydroxytoluene, D-glucose, gallic acid, quercetin, thiobarbituric acid, and noradrenaline were purchased from Sigma-Aldrich (Germany). Propranolol was purchased from Teva Santé (France). DMSO, EDTA, NADH, Folin–Ciocalteu reagent, and sodium pyruvate were from Carl-Roth (Kalshur, Germany). L-NAME and glibenclamide were bought from Enzo Life Sciences (Lausen, Switzerland). NaHCO₃ was purchased from Riedel‐de Haën AG. KH₂PO_4, KCl, CaCl₂, MgSO_4, NaCl, and orthophosphoric acid were bought from BDH (chemicals Ltd Poole England).

Nguelefack-Mbuyo E.P., Nokam F., Tchinda N.L., Goumtsa A.F., Tsabang N, & Nguelefack T.B. (2022). Vasorelaxant and Antioxidant Effects of Aframomum pruinosum Gagnep. (Zingiberaceae) Seed Extracts May Mediate Their Cardioprotective Activity against Isoproterenol-Induced Myocardial Infarction. Evidence-based Complementary and Alternative Medicine : eCAM, 2022, 7257448.

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Mast Cell Degranulation Assay

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The following reagents were obtained from the indicated suppliers: Evans blue, bradykinin, anti-dinitrophenol IgE and L-phenylephrine hydrochloride (Sigma-Aldrich, St. Louis, MO, USA); compound 48/80 (Nacalai tesque, Kyoto, Japan) formamide, histamine dihydrochloride, diphenhydramine, and cimetidine (Wako, Osaka, Japan); Y27632 (Roche Diagnostics Gmbh, Mannheim, Germany); 2-pyridylethylamine dihydrochloride (Tocris Bioscience, Bristol, UK); L-NAME (Enzo Life Sciences, New York, NY, USA); bisindolylmaleimide 1 and DNP-human serum albumin (Calbiochem, San Diego, CA, USA); endothelial growth medium-2 and Bulletkit medium (Lonza, Basel, Switzerland).

Ashina K., Tsubosaka Y., Nakamura T., Omori K., Kobayashi K., Hori M., Ozaki H, & Murata T. (2015). Histamine Induces Vascular Hyperpermeability by Increasing Blood Flow and Endothelial Barrier Disruption In Vivo. PLoS ONE, 10(7), e0132367.

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