Photon 2

The single crystals of 1, 2, and 4 were immersed in FOMBLIN oil (HVAC 140/13, Sigma-Aldrich), mounted on a glass fiber, and examined on a Bruker D8 VENTURE diffractometer equipped with an Oxford Cryostream 800 low-temperature device using a nickel-filtered Cu K¦Á radiation source (λ = 1.54178 Å) and a Bruker PHOTON II detector at 150 K and 298 K, respectively. All data were integrated with SAINT and a multi-scan absorption correction using TWINABS was applied. The structures were solved by direct methods using SHELXT and refined by full-matrix least-squares methods against F² by SHELXL-2018/1. All non-hydrogen atoms were refined with anisotropic displacement parameters. The hydrogen atoms were refined their pivot atoms for terminal sp³ carbon atoms and 1.2 times for all other carbon atoms.

Single-crystal diffraction
data were collected using a Bruker D8 VENTURE diffractometer equipped
with a Bruker PHOTON II detector at 150 K using graphite monochromated
Mo Kα radiation (λ = 0.71073). Data reduction was done
using the APEX3 program. Absorption correction based on multiscan
was obtained by SADABS. The structure was solved and refined using
SHELXT and SHELXL packages correspondingly, using the OLEX2 program.^{51 (link)−53 (link)} The electron density within the voids was accounted for using the
SQUEEZE program implemented in PLATON.^{54 (link)}Crystal data for ZIF-UC-6: C_13.59H_12.78N_8.39Zn₂, M_r =
424.36, crystal dimensions 0.195 × 0.156 × 0.077 mm, Orthorhombic, a = 15.839(2) Å, b = 15.599(2) Å, c = 17.984(2) Å, α = β = γ = 90°, V = 4443.3(9) ų, space group, Pbca, (no. 61), T = 150 K, Z = 8, 24514
measured reflections, 4524 independent reflections (R_int = 0.0593), which were used in all calculations. The
final R₁ = 0.053 for 3285 observed data R[F² > 2σ(F²)] and wR(F²) = 0.139 (all data). CSD deposition 2115059.

Tibia cortical mineral crystallinity and crystal orientation were measured by X-ray diffraction (XRD), as described in more detail in [22 (link)]. A 1-cm² portion of cortical bone that was cut from the tibia mid-shaft was analysed in transmission mode with a X-ray single crystal diffractometer (D8 VENTURE, Bruker) equipped with an area detector (PHOTON II) and a Mo radiation (0.2 mm collimator). Measurements related to bone mineral crystallinity (maturity) and mineral organization (apatite crystal orientation) were determined from XRD data, as described in Table 1.