Wehi 539

Manufactured by ChemScene

Sourced in United States

WEHI-539 is a selective Bcl-2 inhibitor. It functions by binding to and inhibiting the anti-apoptotic protein Bcl-2.

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Lab products found in correlation

Thiazolyl blue tetrazolium bromide, by Merck Group (2 mentions) Hoechst 33588, by Merck Group (2 mentions) Dimethyl sulfoxide (dmso), by Merck Group (2 mentions) Propidium iodide, by Merck Group (2 mentions) Fetal bovine serum (fbs), by Merck Group (2 mentions) Rpmi 1640 medium, by Merck Group (2 mentions) Dmem medium, by Lonza (2 mentions) Venetoclax, by Active Motif (1 mentions) Tetramethylrhodamine methyl ester tmrm, by Thermo Fisher Scientific (1 mentions) 2 deoxy d glucose, by Merck Group (1 mentions) D glucose, by Merck Group (1 mentions) Sodium pyruvate, by Merck Group (1 mentions) Paclitaxel, by Selleck Chemicals (1 mentions) Cisplatin, by Selleck Chemicals (1 mentions) Abt 199, by Active Motif (1 mentions) P nitrophenyl phosphate substrate, by Merck Group (1 mentions) Dmem f12, by Thermo Fisher Scientific (1 mentions) Insulin, by Merck Group (1 mentions) A 1210477, by Abbvie (1 mentions)

2 protocols using wehi 539

Cytotoxicity Evaluation of Venetoclax and WEHI-539

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Fetal bovine serum, RPMI 1640 medium, Thiazolyl Blue Tetrazolium Bromide (MTT), dimethyl sulfoxide (DMSO), sodium pyruvate, D-glucose, 2-deoxy-D-glucose, Hoechst 33588 and propidium iodide (PI) came from Sigma-Aldrich (Dublin, Ireland). DMEM medium was purchased from Lonza (Analab Ltd, Lisburn, United Kindom). Tetramethylrhodamine methyl ester (TMRM) was from Invitrogen (Biosciences, Ireland). Venetoclax was purchased from Active Biochem (Maplewood, NJ, USA), WEHI-539 from ChemScene (South Brunswick, NJ, USA).

Lucantoni F., Düssmann H., Llorente-Folch I, & Prehn J.H. (2018). BCL2 and BCL(X)L selective inhibitors decrease mitochondrial ATP production in breast cancer cells and are synthetically lethal when combined with 2-deoxy-D-glucose. Oncotarget, 9(40), 26046-26063.

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Cytotoxicity evaluation of anti-apoptotic inhibitors

Check if the same lab product or an alternative is used in the 5 most similar protocols

Fetal bovine serum, RPMI 1640 medium, insulin, p-Nitrophenyl Phosphate Substrate (pNPP), Thiazolyl Blue Tetrazolium Bromide (MTT), dimethyl sulfoxide (DMSO), Hoechst 33588, and propidium iodide (PI) came from Sigma-Aldrich (Dublin, Ireland). DMEM medium was purchased from Lonza (Analab Ltd, Lisburn, United Kindom) and DMEM/F12 from Gibco (Biosciences, Dún Laoghaire, Ireland). ABT199 was purchased from Active Biochem (Maplewood, NJ, USA), WEHI-539 from ChemScene (South Brunswick, NJ, USA) and A-1210477 was obtained from AbbVie (North Chicago, IL, USA). Cisplatin and paclitaxel were purchased from Selleckchem (Stratech Scientific Ltd, Newmarket, United Kindom).

Lucantoni F., Lindner A.U., O’Donovan N., Düssmann H, & Prehn J.H. (2018). Systems modeling accurately predicts responses to genotoxic agents and their synergism with BCL-2 inhibitors in triple negative breast cancer cells. Cell Death & Disease, 9(2), 42.

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