Ketamine hydrochloride

BU224 hydrochloride, 2-BFI hydrochloride, tracizoline oxalate, phenyzoline oxalate and CR4056 were synthesized according to standard procedures at the Research Triangle Institute and fully characterized by NMR and elemental analysis. RS45041 ((4-chloro-2-(imidazolin-2-yl) isoindoline) was kindly provided by National Institute of Mental Health’s Chemical Synthesis and Drug Supply program (Bethesda, MD, USA). Idazoxan hydrochloride, agmatine hydrochloride, clonidine hydrochloride, naltrexone hydrochloride, harmane hydrochloride, haloperidol, and MDL100907 were purchased from Sigma-Aldrich (St. Louis, MO, USA). Ketamine hydrochloride was purchased from Patterson Veterinary (Devens, MA, USA). Morphine sulfate, methadone hydrochloride and methamphetamine hydrochloride were provided by Research Technology Branch, National Institute on Drug Abuse, National Institutes of Health (Rockville, MD, USA). All drugs were dissolved in 0.9% physiological saline except otherwise noted. CR4056 was dissolved in 20% dimethyl sulfoxide (DMSO) with saline and a drop of hydrochloric acid. haloperidol was dissolved in 0.9% physiological saline with a drop of acetic acid. MDL100907 was dissolved in 20% DMSO with saline.