Synapt g2 si hrms esi q tof device

Manufactured by Waters Corporation

The Synapt G2-Si HRMS ESI-Q-TOF device is a high-resolution mass spectrometer that combines electrospray ionization (ESI), quadrupole (Q), and time-of-flight (TOF) technologies. It is designed to provide accurate mass measurements and high-resolution analysis of a wide range of molecular compounds.

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Lab products found in correlation

Acquity uplc csh c18, by Waters Corporation (2 mentions) Masslynx, by Waters Corporation (2 mentions) Acquity uplc 1 class system, by Waters Corporation (2 mentions)

Spelling variants of this product

Synapt G2-Si (145 citations) Synapt G2 (120 citations) Synapt G2-Si Q-TOF (21 citations) ESI-Q-TOF (9 citations)

2 protocols using synapt g2 si hrms esi q tof device

LC-MS Steroid Metabolite Analysis

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Steroid metabolites were analyzed by an Acquity I-class UPLC system (Waters) using an Acquity UPLC CSH C18 (1.7 μm, 2.1 × 100 mm) column coupled to a Synapt G2-Si HRMS ESI-Q-TOF device (Waters). The acetonitrile gradient was as described above. Samples were measured in positive mode with a capillary voltage of 3 kV, 100°C source temperature, 450°C desolvation temperature, 750 liter min⁻¹ N₂ desolvation gas flow, and 30 liter min⁻¹ N₂ cone gas flow. LC-MS metabolites were evaluated using MassLynx (Waters). Metabolites were identified by their retention times, UV-vis spectra, by comparison with authentic standards, and m/z values.

Jacoby C., Krull J., Andexer J., Jehmlich N., von Bergen M., Brüls T, & Boll M. (2020). Channeling C1 Metabolism toward S-Adenosylmethionine-Dependent Conversion of Estrogens to Androgens in Estrogen-Degrading Bacteria. mBio, 11(4), e01259-20.

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UPLC-HRMS Metabolite Profiling

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Metabolites were analysed by an Acquity I-class UPLC system (Waters) using an Acquity UPLC CSH C18 (1.7 µm, 2.1 × 100 mm) column coupled to a Synapt G2-Si HRMS ESI-Q-TOF device (Waters). For separation, an aqueous 10 mM NH₄OAc/acetonitrile gradient was applied. Samples were measured in positive mode with a capillary voltage of 2 kV, 100 °C source temperature, 450 °C desolvation temperature, 1000 L min^–1 N₂ desolvation gas flow, and 30 L min^–1 N₂ cone gas flow. Evaluation of LC-MS metabolites was performed using MassLynx (Waters). Metabolites were identified by their retention times, UV-vis spectra, m/z values.

Jacoby C., Ferlaino S., Bezold D., Jessen H., Müller M, & Boll M. (2020). ATP-dependent hydroxylation of an unactivated primary carbon with water. Nature Communications, 11, 3906.

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