Log In Sign up
The largest database of trusted experimental protocols

Dexamethasone (dex)

Manufactured by Baxter
Visit Supplier
Sourced in United States

Dexamethasone is a synthetic glucocorticoid medication used in a variety of medical applications. It functions as an anti-inflammatory and immunosuppressant agent.

Automatically generated - may contain errors

Lab products found in correlation

Sterile round 5 mm glass cover slip, by Electron Microscopy Sciences (2 mentions) Carprofen, by Pfizer (2 mentions) Naloxone hydrochloride dihydrate, by Merck Group (1 mentions)

3 protocols using dexamethasone (dex)

1

Neuroendocrine Response to Drug Administration

Check if the same lab product or an alternative is used in the 5 most similar protocols
Naloxone hydrochloride dihydrate and oCRH were purchased from Sigma-Aldrich Co., St. Louis, MO, USA. ACTH (Cortrosyn; 0.25 mg/vial reconstituted with sterile saline; Amphastar Pharmaceuticals, Inc., Rancho Cucamonga, CA, USA) and dexamethasone (10 and 4 mg/ml for the ACTH and dexamethasone profiles, respectively; Baxter, Deerfield, IL, USA) were obtained in a commercial formulation from the Wake Forest University Baptist Medical Center pharmacy. All drugs were diluted in sterile saline to make the appropriate concentrations. Ethanol (95%, Warner-Graham, Cockeysville, MD, USA) was diluted in tap water to a concentration of 20% (w/v) for the 1.0 g/kg dose and 30% (w/v) for the 1.5 g/kg dose to keep volume constant across both doses.
Jimenez V.A., Porcu P., Morrow A.L, & Grant K.A. (2017). Adaptations in Basal and Hypothalamic–Pituitary–Adrenal-Activated Deoxycorticosterone Responses Following Ethanol Self-administration in Cynomolgus Monkeys. Frontiers in Endocrinology, 8, 19.
+ Open protocol
+ Expand
2

Chronic Glass-Covered Cranial Window Implantation

Cited 1 time
Check if the same lab product or an alternative is used in the 5 most similar protocols
Chronic glass-covered cranial windows were implanted as previously described 53 , 54 (link). Briefly, PND 14 mice were anesthetized with isoflurane (5% induction, 2% maintenance via nose cone) and placed in a stereotaxic frame over a warm water re-circulating blanket. Dexamethasone (0.2 mg/kg; Baxter Healthcare Corp.) and carprofen (5 mg/kg; Pfizer) were administered subcutaneously to reduce brain edema and local tissue inflammation. A 2–3 mm craniotomy was performed with a pneumatic dental drill. The center of the craniotomy was placed over the left hemisphere barrel cortex. A sterile round 5 mm glass cover slip (#1; Electron Microscopy Sciences) was gently laid over the dura matter and glued to the skull with cyanoacrylate-based glue. Dental acrylic was then applied to the skull surface and up to the wound edges. A titanium bar (0.125 × 0.375 × 0.05 inch) was embedded in the dental acrylic to secure the mouse on to the stage for imaging. Following recovery for ~1 h, mouse pups were returned to their cages with their dam and littermates.
He Q., Arroyo E.D., Smukowski S.N., Xu J., Piochon C., Savas J.N., Portera-Cailliau C, & Contractor A. (2018). Critical Period Inhibition of NKCC1 Rectifies Synapse Plasticity in the Somatosensory cortex and Restores Adult Tactile Response Maps in Fragile X Mice. Molecular psychiatry, 24(11), 1732-1747.
+ Open protocol
+ Expand
3

Chronic Glass-Covered Cranial Window Implantation

Cited 1 time
Check if the same lab product or an alternative is used in the 5 most similar protocols
Chronic glass-covered cranial windows were implanted as previously described 53 , 54 (link). Briefly, PND 14 mice were anesthetized with isoflurane (5% induction, 2% maintenance via nose cone) and placed in a stereotaxic frame over a warm water re-circulating blanket. Dexamethasone (0.2 mg/kg; Baxter Healthcare Corp.) and carprofen (5 mg/kg; Pfizer) were administered subcutaneously to reduce brain edema and local tissue inflammation. A 2–3 mm craniotomy was performed with a pneumatic dental drill. The center of the craniotomy was placed over the left hemisphere barrel cortex. A sterile round 5 mm glass cover slip (#1; Electron Microscopy Sciences) was gently laid over the dura matter and glued to the skull with cyanoacrylate-based glue. Dental acrylic was then applied to the skull surface and up to the wound edges. A titanium bar (0.125 × 0.375 × 0.05 inch) was embedded in the dental acrylic to secure the mouse on to the stage for imaging. Following recovery for ~1 h, mouse pups were returned to their cages with their dam and littermates.
He Q., Arroyo E.D., Smukowski S.N., Xu J., Piochon C., Savas J.N., Portera-Cailliau C, & Contractor A. (2018). Critical Period Inhibition of NKCC1 Rectifies Synapse Plasticity in the Somatosensory cortex and Restores Adult Tactile Response Maps in Fragile X Mice. Molecular psychiatry, 24(11), 1732-1747.
+ Open protocol
+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required

Sign up now

Revolutionizing how scientists
search and build protocols!