224Ra/
212Pb generator (VMT-a-GEN) was manufactured by Viewpoint Molecular Targeting, Inc. (Coralville, IA, USA) using
228Th stock obtained from the US Department of Energy Oak Ridge National Laboratory (Oak Ridge, TN, USA).
203PbCl
2 was provided by the Cyclotron Facility at the University of Alberta (Edmonton, AB, Canada).
68GaCl
3 was kindly provided by Dr. David Dick from the Department of Radiology at the University of Iowa (Iowa City, IA, USA). H-threoninol(But)-2-Cl-Trt-resin,
Fmoc-protected amino acids, Fmoc-NH-PEG
2-propionic acid and [Bis(dimethylamino)methylene]-1H-1,2,3-triazolo [4,5-b]pyridinium 3-oxide hexafluorophosphate (HATU) were purchased from AnaSpec (Fremont, CA, USA). Instant thin layer chromatography (iTLC) paper was purchased from Agilent (Santa Clara, CA, USA). Pb and RE2 resins were provided by Eichrom Technologies (Lisle, IL, USA). Empty polypropylene SPE tubes with 20 μm PE frits were obtained from Millipore Sigma (Burlington, MA, USA). Sep-Pak
® C18 cartridges were purchased from Waters Corporation (Milford, MA, USA). Other chemicals were purchased from Thermo Fisher Scientific (Waltham, MA, USA). CD1-Elite SOPF mice were purchased from Charles River Laboratory (Wilmington, MA, USA).
Athymic nude mice were obtained from Envigo (Indianapolis, IN, USA). SSTR2-positive rat pancreatic cancer cell line AR42J was purchased from ATCC (Manassas, VA, USA).
Li M., Baumhover N.J., Liu D., Cagle B.S., Boschetti F., Paulin G., Lee D., Dai Z., Obot E.R., Marks B.M., Okeil I., Sagastume E.A., Gabr M., Pigge F.C., Johnson F.L, & Schultz M.K. (2023). Preclinical Evaluation of a Lead Specific Chelator (PSC) Conjugated to Radiopeptides for 203Pb and 212Pb-Based Theranostics. Pharmaceutics, 15(2), 414.