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Propylene glycol

Manufactured by Chempur
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Sourced in Poland

Propylene glycol is a colorless, odorless, and viscous liquid. It is a common ingredient used in various laboratory applications due to its chemical and physical properties.

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Lab products found in correlation

Phospholipon 90g, by Lipoid (4 mentions) K2s2o8, by Chempur (2 mentions) Quercetin, by Merck Group (2 mentions) Fetal bovine serum (fbs), by PAN Biotech (2 mentions) Formic acid, by Merck Group (2 mentions) Sodium hydrogen carbonate, by Chempur (2 mentions) Acetic acid, by Avantor (2 mentions) Sodium chloride (nacl), by Chempur (2 mentions) Ethanol, by Chempur (2 mentions) Disodium phosphate, by Merck Group (2 mentions) Sodium sulphate anhydrous, by Chempur (2 mentions) Methanol, by Chempur (2 mentions) Trolox, by Merck Group (2 mentions) Potassium dihydrogen phosphate, by Merck Group (2 mentions) Hydrochloric acid (hcl), by Chempur (2 mentions) Gallic acid, by Merck Group (2 mentions) Dulbecco s modified eagle s medium dmem high glucose, by Merck Group (1 mentions) Hacat immortalized human keratinocytes, by CLS Cell Lines Service (1 mentions) Neutral red solution 3.3 g l, by Merck Group (1 mentions) L tyrosine, by Merck Group (1 mentions)

12 protocols using propylene glycol

1

Highly Concentrated Iron Formulation for Anemia

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Example 6

A highly concentrated iron formulation for use as an additive or dietary supplement in the treatment of anemia was prepared having the following ingredients:

ItemNameAmount [mg]
1.Purified soybean phosphatidylcholine220.0
3.Iron (III) diphosphate20.0
4.Vitamin E10.0
5.Phosphate buffer560.0
6.Natural aroma5.0
7.Sweetening substance5.0
Total:1000.0

The product was prepared by dissolving 220 mg Phospholipon 90G (Lipoid AG) in 180 mg propylene glycol (Chempur) and stirring this mixture (4 h, RT, 60 RPM) until a homogeneous lipid yellow solution was obtained. Said solution was mixed (12 h, RT, 200 RPM) with 580 mg of an aqueous phase containing 20 mg iron(III)diphosphate buffered with phosphate buffer (0.01 M, pH 7.2). The resulting mixture was extruded through a polycarbonate filter with a pore diameter of 100 nm in one cycle. Vitamin E as an antioxidant, natural aroma, and a sweetening substance were sequentially added and stirred (0.5 h, RT, 60 RPM) in order to obtain the final product.

US11759424B2. High-efficiency encapsulation of hydrophilic compounds in unilamellar liposomes (2023-09-19). LIPID SYSTEMS SP. Z.O.O. [PL]. Inventors: Magdalena Przybylo [PL], Marek Langner [PL], Tomasz Borowik [PL].
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2

Melanoma and Keratinocyte Cell Lines Characterization

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A375 (ATCC CRL-1619) human malignant melanoma cell line was purchased from LGC Standards (Łomianki, Poland). HaCaT immortalized human keratinocytes were purchased from CLS Cell Lines Service GmbH (Eppelheim, Germany). Fetal bovine serum (FBS) was obtained from Pan-Biotech (Aidenbach, Germany). Dulbecco’s modified Eagle’s medium (DMEM)/high glucose, Dulbecco’s phosphate buffered saline (DPBS), mushroom tyrosinase from Agaricus bisporus, L-tyrosine, 3,4-dihydroxy-l-phenylalanine (L-DOPA), 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), zinc oxide, L-ascorbic acid, neutral red solution (3.3 g/L) and standards of caffeic acid, chlorogenic acid and quercetin were purchased from Sigma Aldrich (St. Louis, MO, USA). The purity of the reference compounds exceeded 95%. Propylene glycol (>99.8% purity) and K2S2O8 were obtained from Chempur (Piekary Slaskie, Poland). The solvents used for compositional study of the extracts by HPLC-MS, namely water, acetonitrile and formic acid were purchased from Merck (Darmstadt, Germany).
Gaweł-Bęben K., Strzępek-Gomółka M., Czop M., Sakipova Z., Głowniak K, & Kukula-Koch W. (2020). Achillea millefolium L. and Achillea biebersteinii Afan. Hydroglycolic Extracts–Bioactive Ingredients for Cosmetic Use. Molecules, 25(15), 3368.
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3

Alginate-Based Bioplastic Formulation

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Sodium alginate (Brookfield viscosity 350–550 mPa × s, c = 1%, w/w at 20 °C) was supplied by Across Organics (Geel, Belgium). Chestnut extract Farmatan (≥ 76% tannins) was provided by Tanin Sevnica (Sevnica, Slovenia). Calcium chloride (purity ≥ 96%) and acetic acid (99.5–99.9%) were purchased from Avantor Performance Materials (Gliwice, Poland). Glycerol was supplied by Merck (Darmstadt, Germany), while epoxidized soybean oil and epoxidized palm oil were from Inbra Indústrias Químicas LTDA (Sao Paulo, Brasil) and Malaysian Palm Oil Board (Kajang, Malaysia), respectively. Propylene glycol, cyclohexene and toluene (both pure p.a.), formic acid (85.0%), hydrogen peroxide (30.0%), disodium hydrogen phosphate dihydrate and sodium hydrogen carbonate (pure p.a.) were purchased from Chempur (Piekary Śląskie, Poland). Oleic acid (90.0%) was supplied by Alfa Aesar (Ward Hill, MA, USA), and succinic acid (≥ 99.5%) by POL-AURA (Zabrze, Poland). Methanesulfonic acid (> 99.0%) was provided by TCI (Zwijndrecht, Belgium).
Janik W., Nowotarski M., Ledniowska K., Shyntum D.Y., Krukiewicz K., Turczyn R., Sabura E., Furgoł S., Kudła S, & Dudek G. (2023). Modulation of physicochemical properties and antimicrobial activity of sodium alginate films through the use of chestnut extract and plasticizers. Scientific Reports, 13, 11530.
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4

Highly Concentrated Iron Formulation for Anemia

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Example 6

A highly concentrated iron formulation for use as an additive or dietary supplement in the treatment of anemia was prepared having the following ingredients:

ItemNameAmount [mg]
1.Purified soybean phosphatidylcholine220.0
3.Iron (III) diphosphate20.0
4.Vitamin E10.0
5.Phosphate buffer560.0
6.Natural aroma5.0
7.Sweetening substance5.0
Total:1000.0

The product was prepared by dissolving 220 mg Phospholipon 90G (Lipoid AG) in 180 mg propylene glycol (Chempur) and stirring this mixture (4 h, RT, 60 RPM) until a homogeneous lipid yellow solution was obtained. Said solution was mixed (12 h, RT, 200 RPM) with 580 mg of an aqueous phase containing 20 mg iron(III)diphosphate buffered with phosphate buffer (0.01 M, pH 7.2). The resulting mixture was extruded through a polycarbonate filter with a pore diameter of 100 nm in one cycle. Vitamin E as an antioxidant, natural aroma, and a sweetening substance were sequentially added and stirred (0.5 h, RT, 60 RPM) in order to obtain the final product.

US11426349B2. High-efficiency encapsulation of hydrophilic compounds in unilamellar liposomes (2022-08-30). LIPID SYSTEMS SP. Z.O.O. [PL]. Inventors: Magdalena Przybylo [PL], Marek Langner [PL], Tomasz Borowik [PL].
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5

Antioxidant and Anti-inflammatory Assays

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2,2-diphenyl-1-picrylhydrazyl (DPPH), 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox), ibuprofen, lidocaine hydrochloride, and caffeine were purchased from Sigma Aldrich (Poznań, Poland); disodium phosphate and potassium dihydrogen phosphate from Merck, Darmstadt (Germany); Biobase, beeswax were purchased from Mazidła.com (Poznań, Poland); grape seed oil was purchased from Monini (Spoleto, Italy); sodium acetate anhydrous, potassium persulfate, potassium acetate, xylene, 99.5% acetic acid, aluminium chloride, 36% hydrochloric acid, sodium chloride, potassium chloride, sodium sulphate anhydrous as well as propylene glycol, ethanol, and methanol were from Chempur (Piekary Śląskie, Poland), whereas acetonitrile for HPLC from J.T. Baker, (Landsmeer, The Netherlands). All reagents were of analytical grade.
Nowak A., Duchnik W., Makuch E., Kucharski Ł., Ossowicz-Rupniewska P., Cybulska K., Sulikowski T., Moritz M, & Klimowicz A. (2021). Epilobium angustifolium L. Essential Oil—Biological Activity and Enhancement of the Skin Penetration of Drugs—In Vitro Study. Molecules, 26(23), 7188.
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6

Vitamin C Cancer Treatment Formulation

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Example 5

A highly concentrated vitamin C product for use as an additive or dietary supplement in the treatment of cancer was prepared having the following ingredients:

ItemNameAmount [mg]
1.Purified soybean phosphatidylcholine210.0
3.Vitamin C210.0
4.EDTA10.0
5.Phosphate buffer380.0
6.Natural aroma5.0
7.Sweetening substance5.0
Total:1000.0

The product was prepared by dissolving 210 mg Phospholipon 90G (Lipoid AG) in 180 mg propylene glycol (Chempur) and stirring this mixture (4 h, RT, 60 RPM) until a homogeneous lipid yellow solution was obtained. Said solution was mixed (12 h, RT, 200 RPM) with 590 mg of an aqueous phase containing 210 mg vitamin C buffered with phosphate buffer (0.01 M, pH 7.2). The resulting mixture was extruded through a polycarbonate filter with a pore diameter of 100 nm in one cycle. EDTA, natural aroma and a sweetening substance were sequentially added and stirred (0.5 h, RT, 60 RPM) in order to obtain the final product.

US11759424B2. High-efficiency encapsulation of hydrophilic compounds in unilamellar liposomes (2023-09-19). LIPID SYSTEMS SP. Z.O.O. [PL]. Inventors: Magdalena Przybylo [PL], Marek Langner [PL], Tomasz Borowik [PL].
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7

Vitamin C Supplement for Cancer Treatment

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Example 5

A highly concentrated vitamin C product for use as an additive or dietary supplement in the treatment of cancer was prepared having the following ingredients:

ItemNameAmount [mg]
1.Purified soybean phosphatidylcholine210.0
3.Vitamin C210.0
4.EDTA10.0
5.Phosphate buffer380.0
6.Natural aroma5.0
7.Sweetening substance5.0
Total:1000.0

The product was prepared by dissolving 210 mg Phospholipon 90G (Lipoid AG) in 180 mg propylene glycol (Chempur) and stirring this mixture (4 h, RT, 60 RPM) until a homogeneous lipid yellow solution was obtained. Said solution was mixed (12 h, RT, 200 RPM) with 590 mg of an aqueous phase containing 210 mg vitamin C buffered with phosphate buffer (0.01 M, pH 7.2). The resulting mixture was extruded through a polycarbonate filter with a pore diameter of 100 nm in one cycle. EDTA, natural aroma and a sweetening substance were sequentially added and stirred (0.5 h, RT, 60 RPM) in order to obtain the final product.

US11426349B2. High-efficiency encapsulation of hydrophilic compounds in unilamellar liposomes (2022-08-30). LIPID SYSTEMS SP. Z.O.O. [PL]. Inventors: Magdalena Przybylo [PL], Marek Langner [PL], Tomasz Borowik [PL].
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8

Chitosan-Tannin Composite Hydrogel Synthesis

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Chitosan 0.03–0.1 Pa × s (MW = 250 kg/mol, DD ≥ 90%) was purchased from Sigma-Aldrich (Steinheim, Germany). Acetic acid was purchased from Avantor (Gliwice, Poland) (99.5–99.9%), and Farmatan chestnut extract (≥76% tannins) was provided by Tanin Sevnica (Sevnica, Slovenia). Propylene glycol, cyclohexene (pure p.a.) and sodium hydrogen carbonate (pure p.a.) were purchased from Chempur (Piekary Śląskie, Poland). Methanesulfonic acid (>99.0%) was provided by TCI (Zwijndrecht, Belgium). Nanofibrillated cellulose (10–20 nm wide, 2–3 µm length) was purchased from Nanografi Nano Technology (Ankara, Türkiye).
Janik W., Nowotarski M., Ledniowska K., Biernat N., A.b.d.u.l.l.a.h., Shyntum D.Y., Krukiewicz K., Turczyn R., Gołombek K, & Dudek G. (2023). Effect of Time on the Properties of Bio-Nanocomposite Films Based on Chitosan with Bio-Based Plasticizer Reinforced with Nanofiber Cellulose. International Journal of Molecular Sciences, 24(17), 13205.
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9

Bioactive Compounds Extraction and Analysis

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Propylene glycol (PG, >99.8% purity), Folin–Ciocalteu reagent and K2S2O8 were obtained from Chempur (Piekary Śląskie, Poland). Ethanol (EtOH, >99.8% purity) was obtained from Honeywell. Trolox, quercetin (>95% purity), gallic acid (>97.5% purity), 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), tyrosinase from Agaricus bisporus, 3,4-dihydroxy-l-phenylalanine (L-DOPA), kojic acid (≥98.5% purity), TiO2, Dulbecco’s phosphate buffered saline (DPBS), Dulbecco’s modified Eagle’s medium (DMEM), bovine serum albumin (BSA), and Neutral Red Solution in DPBS (3.3 g/L) were purchased from Sigma Aldrich (Merck, Darmstadt, Germany). Fetal bovine serum (FBS) was obtained from Pan-Biotech (Aidenbach, Germany). The solvents used for the compositional study of the extracts by HPLC-MS (water, acetonitrile and formic acid) and were purchased from Merck (Darmstadt, Germany).
Gaweł-Bęben K., Czech K., Strzępek-Gomółka M., Czop M., Szczepanik M., Lichtarska A, & Kukula-Koch W. (2022). Assessment of Cucurbita spp. Peel Extracts as Potential Sources of Active Substances for Skin Care and Dermatology. Molecules, 27(21), 7618.
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10

Formulation and Characterization of Resveratrol-Loaded Nanoparticles

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Trans-resveratrol (RSV, purity >99%) was purchased from Mega Resveratrol (Danbury, CT, USA). Polyvinyl alcohol (PVA, Mowiol® 56–98, Mw ~195.000 Da; degree of hydrolysis ~98.4 ± 0.4mol%) was obtained from Merck (Warsaw, Poland). Propylene glycol (PG) was acquired from Chempur (Piekary Śląskie, Poland). Labrasol (L) was kindly donated by Gattefossé (Saint-Priest, France). Tween 80 was purchased from Croda (Cracow, Poland). Cremophor RH40 was obtained from BASF (Warsaw, Poland). Potassium dihydrogen phosphate, disodium hydrogen phosphate, and sodium chloride were purchased from Avantor Performance Materials (Gliwice, Poland). All these reagents were of the analytical grade.
Górska A., Krupa A., Majda D., Kulinowski P., Kurek M., Węglarz W.P, & Jachowicz R. (2021). Poly(Vinyl Alcohol) Cryogel Membranes Loaded with Resveratrol as Potential Active Wound Dressings. AAPS PharmSciTech, 22(3), 109.
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