QFPD granules were a gift from Renmin Hospital of Wuhan University. The 21 raw materials were purchased from Yifeng Pharmacy Chain Co., Ltd. (Changde, China). Acetonitrile (HPLC grade) and methanol (HPLC grade) were purchased from Merck (Darmstadt, Germany). Formic acid was purchased from Thermo Fisher Scientific (Waltham, MA, USA). Watsons distilled water was obtained from Jingdong Mall (Beijing, China).
Authentic standards of cytosine, sucrose, citric acid, uridine, adenosine, 2-pyrrolidinecarboxylic acid, and guanosine were purchased from Sigma-Aldrich (St. Louis, MO, USA). Nicotinic acid was obtained from Sinopharm Chemical Reagent Co., Ltd. (Shanghai, China). Nicotinamide and tangeretin were purchased from Shanghai Aladdin Bio-Chem Technology Co., Ltd. (Shanghai, China). Salicylic acid was acquired from Ascender Chemical Co., Ltd. (Shanghai, China). Glycyrrhizic acid, 18-β-glycyrrhetinic acid, isoliquiritigenin, baicalin, and narirutin were purchased from Shanghai Macklin Biochemical Co., Ltd. (Shanghai, China). Chlorogenic acid was a gift from Thermo Fisher Scientific.
Authentic standards of cytosine, sucrose, citric acid, uridine, adenosine, 2-pyrrolidinecarboxylic acid, and guanosine were purchased from Sigma-Aldrich (St. Louis, MO, USA). Nicotinic acid was obtained from Sinopharm Chemical Reagent Co., Ltd. (Shanghai, China). Nicotinamide and tangeretin were purchased from Shanghai Aladdin Bio-Chem Technology Co., Ltd. (Shanghai, China). Salicylic acid was acquired from Ascender Chemical Co., Ltd. (Shanghai, China). Glycyrrhizic acid, 18-β-glycyrrhetinic acid, isoliquiritigenin, baicalin, and narirutin were purchased from Shanghai Macklin Biochemical Co., Ltd. (Shanghai, China). Chlorogenic acid was a gift from Thermo Fisher Scientific.