Lcms it tof

Manufactured by JEOL

Sourced in Japan

The LCMS-IT-TOF is a liquid chromatography-mass spectrometry (LC-MS) system that combines an ion trap (IT) and time-of-flight (TOF) mass analyzer. It is designed to provide accurate mass measurements and reliable structural information for a wide range of analytes. The LCMS-IT-TOF offers high sensitivity, resolution, and mass accuracy for applications in various fields, such as pharmaceutical research, environmental analysis, and metabolomics.

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Lab products found in correlation

Lcms 2010ev, by Shimadzu (2 mentions) Gcmate 2, by JEOL (2 mentions) 70pf 254 plate, by Fujifilm (2 mentions) Av 300 spectrometer, by Bruker (1 mentions) Sepa 300 polarimeter, by Horiba (1 mentions) Ascend 500 spectrometer, by Bruker (1 mentions) P 2200 polarimeter, by Jasco (1 mentions) Av 300, by Bruker (1 mentions) Sx 102a, by JEOL (1 mentions) Rp 18 f254, by Merck Group (1 mentions) Spd 20avp uv vis detector, by Shimadzu (1 mentions) Rp 18 wf254s, by Merck Group (1 mentions) Cosmosil 140c18 opn, by Nacalai Tesque (1 mentions)

3 protocols using lcms it tof

Analytical Techniques for Compound Characterization

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Silica gel 70PF 254 Plate-Wako was used for TLC (thin layer chromatography) and column chromatography was performed on Wakogel®, 60 N, (particle size, 63–212 μm) or Wakogel®, C-300E, (particle size, 45–75 μm). Melting points were obtained on a Yanaco micro melting point apparatus and are uncorrected. Low-resolution mass spectra (LRMS) were recorded on Shimadzu LCMS-2010EV (ESI) and high-resolution mass spectra (HRMS) were recorded on Shimadzu LCMS-IT-TOF (ESI) or JEOL GC mate II (EI). ¹H NMR spectra were recorded using Bruker AV 300 spectrometer, chemical shifts (δ) are quoted in parts per million (ppm) referenced to tetramethylsilane (0 ppm) or the residual solvent peak. ¹³C NMR spectra were recorded on the same spectrometer at 75 MHz, using the residual solvent peak as the internal reference. Optical rotations were recorded using a HORIBA SEPA-300 polarimeter.

Ohnishi K., Hattori Y., Kobayashi K, & Akaji K. (2018). Evaluation of a non-prime site substituent and warheads combined with a decahydroisoquinolin scaffold as a SARS 3CL protease inhibitor. Bioorganic & Medicinal Chemistry, 27(2), 425-435.

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Analytical Techniques for Compound Characterization

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Silica gel 70PF 254 Plate-Wako was used for TLC and column chromatography was performed on Wakogel® 60 N (particle size, 63–212 μm) or Wakogel® C-300E (particle size, 45–75 μm). Low-resolution mass spectroscopy (LRMS) was recorded on Shimadzu LCMS-2010EV (ESI) and high-resolution mass spectroscopy (HRMS) was recorded on Shimadzu LCMS-IT-TOF (ESI) or JEOL GC mate II (EI) or JEOL SX-102A (FAB). ¹H NMR spectroscopy was recorded on a Bruker AV300 or Ascend500 spectrometer. Chemical shifts (δ) are quoted in parts per million (ppm) and referenced to tetramethylsilane (0 ppm) or the residual solvent peak. ¹³C NMR spectroscopy was recorded on the same spectrometer at 75 or 125 MHz using the residual solvent peak as an internal reference. Optical rotations were recorded using a Jasco P-2200 Polarimeter.

Yoshizawa S.I., Hattori Y., Kobayashi K, & Akaji K. (2019). Evaluation of an octahydroisochromene scaffold used as a novel SARS 3CL protease inhibitor. Bioorganic & Medicinal Chemistry, 28(4), 115273.

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Analytical Characterization of Compounds

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The following instruments were used to obtain physical data: specific rotations, a Horiba (Kyoto, Japan) SEPA-300 digital polarimeter (l = 5 cm); IR spectra, JASCO (Tokyo, Japan) FT/IR-4600 Fourier Transform Infrared Spectrometer; ESIMS, Agilent Technologies (CA, US) Quadrupole LC/MS 6130; HRESIMS, SHIMADZU LCMS-IT-TOF; ¹H NMR spectra, JEOL (Tokyo, Japan) JNM-LA 500 (500 MHz) spectrometer; ¹³C-NMR spectra, JEOL JNM-LA 500 (125 MHz) spectrometer; NOESY spectra, JNM-ECA 600 (600 MHz) spectrometer; HPLC, a Shimadzu (Kyoto, Japan) SPD-20AVP UV-VIS detector. YMC-triart C18 (250 × 4.6 mm i.d. and 250 × 10 mm i.d.) and YMC-triart PFP (250 × 4.6 mm i.d. and 250 × 10 mm i.d.) columns were used for analytical and preparative purposes. The following experimental materials were used for chromatography: normal-phase silica gel column chromatography, silica gel BW-200 (Fuji Silysia Chemical, Ltd. (Aichi, Japan, 150–350 mesh); reversed-phase silica gel column chromatography, Cosmosil 140C₁₈-OPN [Nacalai Tesque (Kyoto, Japan)], TLC, precoated TLC plates with silica gel 60F₂₅₄ [Merck (NJ, US), 0.25 mm] (ordinary phase), and silica gel RP-18 F_254S (Merck, 0.25 mm) (reversed phase); reversed-phase HPTLC, precoated TLC plates with silica gel RP-18 WF_254S. Detection was achieved by spraying with 1% Ce (SO₄) 2–10% aqueous H₂SO₄ followed by heating.

Fukaya M., Nakamura S., Hayashida H., Noguchi D., Nakashima S., Yoneda T, & Matsuda H. (2020). Structures of Cyclic Organosulfur Compounds From Garlic (Allium sativum L.) Leaves. Frontiers in Chemistry, 8, 282.

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