Ethyl 2 bromopropionate

Manufactured by Merck Group

Sourced in United States

Ethyl-2-bromopropionate is a chemical compound used in various laboratory applications. It is a colorless liquid with a characteristic odor. The core function of this product is to serve as a versatile reagent and intermediate in organic synthesis and chemical reactions.

Automatically generated - may contain errors

Lab products found in correlation

4 protocols using ethyl 2 bromopropionate

Radiolabeling of [18F]-FDG Tracer

Cited 1 time

Check if the same lab product or an alternative is used in the 5 most similar protocols

All chemicals obtained commercially were used without further purification unless otherwise indicated. [¹⁸F]-FDG was prepared as previously reported [28 (link)]. Ethyl-2-bromopropionate, acetonitrile (MeCN), dimethylsulfoxide (DMSO), N,N-diisopropylethylamine (DIPEA), bis(4-nitrophenyl)carbonate (NPC), tri-fluoroacetic acid (TFA), and Kryptofix 222 (K2.2.2) were purchased from Sigma-Aldrich (Milwaukee, WI, USA). Sep-Pak light QMA cartridges, Sep-Pak plus C18 cartridges, and Oasis HLB cartridges were achieved from Waters Corporation (Milford, MA, USA). Sep-Pak light QMA cartridges were preconditioned with 5 ml NaHCO₃ aqueous (8.4%) and 10 ml H₂O before using. Sep-Pak plus C18 and Oasis HLB cartridges were preconditioned with 10 ml ethanol and water, respectively, before using. High-performance liquid chromatography (HPLC) separation was performed on at the PET-MF-2V-IT-1 synthesizer (PET Co. Ltd., Beijing, China) building HPLC system with a semipreparative reverse-phase C18 column (106 and 250 mm) equipped with a UV detector (Alltech 201, USA) and a radioactivity detector (PET Co. Ltd., China). The mobile phase was 50% solvent A (0.1% TFA in water): 50% solvent B (0.1% TFA in MeCN) with the flow rate of 4 ml/min.

Zhao J., Wang Y.L., Li X.B., Gao S.Y., Liu S.Y., Song Y.K., Wang J.Y., Xiong Y., Ma H., Jiang L., Yang Z.Y., Tang G.H, & Chu J.P. (2018). Radiosynthesis and Preliminary Biological Evaluation of 18F-Fluoropropionyl-Chlorotoxin as a Potential PET Tracer for Glioma Imaging. Contrast Media & Molecular Imaging, 2018, 8439162.

+ Open protocol

+ Expand

Photochemically Activated Polymer Synthesis

Check if the same lab product or an alternative is used in the 5 most similar protocols

Tris(2‐pyridylmethyl)amine (TPMA, 98 %), copper(II)bromide (CuBr₂, 99 %, Aldrich), ethyl α‐bromophenylacetate (EBPA, 97 %), ethyl 2‐bromopropionate (EBP, 99 %), N,N,N′,N′′,N′‐pentamethyldiethylentriamine (PMDETA, 99 %), and α,α‐dimethoxy‐α‐phenylacetophenone (DMPA, 99 %) were purchased from Sigma–Aldrich and used as received. Methyl methacrylate (M8, 99 %, Sigma–Aldrich), phenylacrylate (M6, 98 %, TCI) and cinnamyl methacrylate (M5, Polysciences) are passed through a plug of basic alumina before use to remove the inhibitor. 2‐[3‐(2H‐Benzotriazol‐2‐yl)‐4‐hydroxyphenyl]ethyl methacrylate (M1, 99 %), 2‐(4‐benzoyl‐3‐hydroxyphenoxy)ethyl acrylate (M2, 98 %), 9‐vinylcarbazole (M3, 99 %) and 9‐vinylanthracene (M4, 97 %) were purchased from Sigma–Aldrich and used as received. The NIR sensitizer Sens (5‐(6‐(2‐(3‐ethyl‐1,1‐dimethyl‐1H‐benzo[e]indol‐2(3H)‐ylidene)ethylidene)‐2‐(2‐(3‐ethyl‐1,1‐dimethyl‐1H benzo[e]‐indol‐3‐ium‐2‐yl)vinyl)cyclohex‐1‐en‐1‐yl)‐1,3‐dimethyl‐2,6‐dioxo‐1,2,3,6 tetrahydropyrimidin‐4‐olate) was received from FEW Chemicals GmbH as S2265. N,N‐Dimethylformamide (DMF, anhydrous, 99.8 %) was purchased from Acros Organics and stored over activated molecular sieves. Methanol (99.9 %, Bernd Kraft), tetrahydrofurane (THF, 99.9 %, Carl Roth) and 2‐butanone (99.0 %, Sigma Aldrich) were used as received.

Kütahya C., Meckbach N., Strehmel V., Gutmann J.S, & Strehmel B. (2020). NIR Light‐Induced ATRP for Synthesis of Block Copolymers Comprising UV‐Absorbing Moieties. Chemistry (Weinheim an Der Bergstrasse, Germany), 26(46), 10444-10451.

+ Open protocol

+ Expand

Synthesis of Multifunctional Peptide Polymers

Check if the same lab product or an alternative is used in the 5 most similar protocols

All reagents were used without further purification unless otherwise specified. Dimethyl 2,6-dibromoheptanedioate, ethyl 2-bromopropionate (EBP), copper(I) acetate, copper(I) bromide, N,N,N’N’,N”-pentamethyldiethylenetriamine (PMDETA), tert-butyl acrylate, alumina inhibitor removal column, and trifluoroacetic acid (TFA) were purchased from Sigma-Aldrich (St Louis, MO, USA). tert-Butyl acrylate was purified by passing through an alumina inhibitor removal column. Sodium azide, acetic anhydride, N,N-dimethylformamide (DMF), tetrahydrofuran (THF), methanol, toluene, and dichloromethane (DCM) were purchased from Fisher Scientific (Pittsburgh, PA, USA). Fmoc-L-valine–OH, Fmoc-L-isoleucine–OH, Fmoc-L-glycine–OH, and Fmoc-L-proline–OH were purchased from Protein Technologies, Inc. (Tucson, AZ, USA), and Fmoc-L-propargylglycine–OH was purchased from AnaSpec, Inc. (Fremont, CA). Water was deionized and filtered through a Barnstead NANOpure Diamond water purification system (Thermo Scientific, Dubuque, IA, USA).

Paik B.A., Blanco M.A., Jia X., Roberts C.J, & Kiick K.L. (2015). Aggregation of poly(acrylic acid)-containing elastin-mimetic copolymers. Soft matter, 11(9), 1839-1850.

+ Open protocol

+ Expand

Synthesis of Ethyl 2-Azidopropionate

Check if the same lab product or an alternative is used in the 5 most similar protocols

Ethyl 2-bromopropionate (99%, Sigma Aldrich) and NaN₃ (≥99.5%, Sigma Aldrich) were used to synthesise ethyl 2-azidopropionate according to a procedure in the literature.^{44 (link)} Propargyl alcohol (99%, Alfa Aesar), copper(ii) chloride, copper(ii) sulfate anhydrous, N,N,N′,N′′,N′′-pentamethyldiethylenetriamine (99%, PMDETA), tris[2-(dimethylamino)ethyl]amine (97%, Me₆TREN), 1,5-pentanediamine (≥97%, PDA), diethylamine (≥99.5%, DEA), methyl acrylate (99%) and deuterochloroform (≥99%, CDCl₃) were obtained from Sigma-Aldrich, and were used without further purification. Isopropylthioxanthone (ITX, Fluka, a mixture of 2- and 4-isomers) was used as a photoinitiator.

Yin B., Croutxé-Barghorn C., Delaite C, & Allonas X. (2019). A new synthetic pathway based on one-pot sequential aza-Michael addition and photoCuAAC click reactions. RSC Advances, 9(9), 4824-4831.

+ Open protocol

+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!