High performance liquid chromatography grade methanol

Manufactured by Tedia

Sourced in United States

High-performance liquid chromatography (HPLC)-grade methanol is a pure solvent used as a mobile phase component in HPLC analysis. It is a colorless, volatile liquid with a high degree of purity and low levels of impurities.

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Lab products found in correlation

Acetonitrile, by Tedia (3 mentions) Milli q purification system, by Merck Group (2 mentions) Fentanyl, by Cerilliant (1 mentions) Ammonium hydroxide, by Merck Group (1 mentions) Formic acid, by Merck Group (1 mentions) Polyethylene glycol 400 peg400, by Sinopharm (1 mentions) Isopropyl myristate, by BASF (1 mentions) Ethyl oleate, by Gattefosse (1 mentions) Oleic acid, by Gattefosse (1 mentions) Medium chain triglycerides, by Gattefosse (1 mentions) Cremophor rh40, by BASF (1 mentions) Cremophor el35, by BASF (1 mentions) Efv d5, by LGC (1 mentions) Ammonium acetate, by Tedia (1 mentions) Methoxyamine hydrochloride, by Merck Group (1 mentions) Bstfa 1 tmcs, by Merck Group (1 mentions) Pyridine, by Merck Group (1 mentions)

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Methanol (197 citations)

6 protocols using high performance liquid chromatography grade methanol

Quantification of Synthetic Opioids in Blood

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Fentanyl and ²H₅-Fentanyl were purchased from Cerilliant (Round Rock, TX). Carfentanil, sufentanil, and their corresponding N-phenyl-²H₅ labeled forms, as well as ¹³C₆-alfentanil HCl were custom synthesized by Battelle (Columbus, OH). Lofentanil, alfentanil, 3-methyl Fentanyl, and α-methyl Fentanyl, were generous gifts from a variety of sources listed in the Acknowledgements. Structures of all target analytes are shown in Figure 1. High-performance liquid chromatography (HPLC)-grade methanol and acetonitrile were purchased from Tedia Company, Inc. (Fairfield, OH). Formic acid (99%) and ammonium hydroxide (28.6%) were purchased from Sigma Aldrich (Pittsburgh, PA). Deionized (DI) water (>18MΩ·cm) was prepared on-site using an installed water purification system (Aqua Solutions, Inc., Jasper, GA). Pooled whole blood and a convenience set of individual whole blood samples were purchased from Tennessee Blood Services (Memphis, TN). Use of deidentified spiked blood from a commercial source was not deemed to constitute human subject research.

Shaner R.L., Schulze N.D., Seymour C., Hamelin E.I., Thomas J.D, & Johnson R.C. (2017). Quantitation of Fentanyl Analogs in Dried Blood Spots by Flow-Through Desorption Coupled to Online Solid Phase Extraction Tandem Mass Spectrometry. Analytical methods : advancing methods and applications, 9, 3876-3883.

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Formulation and Evaluation of Warfarin Capsules

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ITZ was purchased from Shouguang Fukang Pharmaceutical Co, Ltd (Jinan, People’s Republic of China). LAA was obtained from Tianjin Guangfu Fine Chemical Research Institute (Tianjin, People’s Republic of China). HPMC (3.23 mPa.s), F127, and hard gelatin capsules (clear, size 00) were purchased by Sigma-Aldrich (St Louis, MO, USA). Warfarin was provided by the Central Research Institute, Shanghai Pharmaceuticals Holding Co, Ltd (Shanghai, People’s Republic of China). High-performance liquid chromatography (HPLC)-grade methanol was purchased from Tedia (Fairfield, OH, USA). CO₂ (purity: 99.9%) was obtained from Huaming Gas Sales Co, Ltd (Tianjin, People’s Republic of China). Dichloromethane (analytical grade) was purchased from Sinopharm Chemical Reagent Co, Ltd (Shanghai, People’s Republic of China). Deionized water was prepared using a Milli-Q purification system (Millipore, Billerica, MA, USA). All other chemicals were of analytical grade and used as received.

Yin X., Daintree L.S., Ding S., Ledger D.M., Wang B., Zhao W., Qi J, & Wu W. (2015). Itraconazole solid dispersion prepared by a supercritical fluid technique: preparation, in vitro characterization, and bioavailability in beagle dogs. Drug Design, Development and Therapy, 9, 2801-2810.

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Transdermal Delivery of 8-MOP: A Comprehensive Study

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8-MOP were purchased from Japharm (Nanjing, China). 8-MOP tincture (1 mg mL⁻¹ 8-MOP in ethanol–water) was purchased from Huapont Pharm (Chongqing, China). Isopropyl myristate, Cremophor EL35, and Cremophor RH40 were purchased from BASF (Ludwigshafen, Germany). Ethyl oleate, oleic acid, oleoyl macrogolglycerides (Labrafil M 1944 CS), and medium-chain triglycerides were obtained from Gattefossé (France). Polyoxyethylene stearate (Solutol) and polyethylene glycol 400 (PEG₄₀₀) were purchased from Sinopharm Chemical Reagent (Shanghai, China). Cabomer-940 was purchased from Shin-Etsu Chemical Japan. Lactate chitosan (LC), carboxymethyl chitosan (CC), acetic chitosan (AC), and hydroxypropyl chitosan (HC) were purchased from Sinopharm Chemical Reagent (Shanghai, China). 4,8,5′-Trimethylpsoralen (TMP) was purchased from Tauto Biotech (Shanghai, China). High-performance liquid chromatography (HPLC)-grade methanol and acetonitrile were obtained from Tedia (Fairfield, OH, USA). Double-distilled water was used throughout the study. All other chemical reagents and solvents were of analytical grade.

Wu J.Y., Li Y.J., Liu T.T., Ou G., Hu X.B., Tang T.T., Wang J.M., Liu X.Y, & Xiang D.X. (2019). Microemulsions vs chitosan derivative-coated microemulsions for dermal delivery of 8-methoxypsoralen. International Journal of Nanomedicine, 14, 2327-2340.

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HPLC-MS/MS Quantification of HIV Drugs

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Standards, 3TC, AZT, NVP, EFV, RTV, and LPV were purchased from TargetMol (Shanghai, China); corresponding deuterated internal standards (IS), 3TC-d3, AZT-d4, NVP-d3, EFV-d5, RTV-d6, and LPV-d8 were obtained from Toronto Research Chemicals (Toronto, ON, Canada). Ammonium acetate and high-performance liquid chromatography (HPLC)-grade methanol were supplied by Tedia (Fairfield, OH, USA) and Sigma Aldrich (St. Louis, MO, USA), respectively. Tri-distilled water was from Watsons (Hong Kong, China).
Stock solutions of 3TC, NVP, and their corresponding ISs were individually dissolved in methanol at a concentration of 1 mg/mL. AZT, EFV, RTV, and LPV were used at a concentration of 400 μg/mL, with 50 μg/mL IS concentrations. They were all stored at −20°C. The working solutions with mixed six drug standards were obtained by diluting stock solutions with methanol to final concentrations at 0.1–10000 ng/mL. IS solutions were diluted with methanol at 5 ng/mL for 3TC-d3, NVP-d3, RTV-d6 and LPV-d8, 20 ng/mL for AZT-d4, and 100 ng/mL for EFV-d5.

Wu Y., Chu L., Yang H., Wang W., Zhang Q., Yang J., Qiao S., Li X., Shen Z., Zhou Y., Liu S, & Deng H. (2021). Simultaneous Determination of Six Antiretroviral Drugs in Human Hair Using an LC-ESI+-MS/MS Method: Application to Adherence Assessment. Therapeutic drug monitoring, 43(6), 756-765.

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Isolation and Characterization of Bioactive Compounds from P. perfoliatum

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P. perfoliatum was taken from Guiyang, Guizhou Province, China and identified by Professor Sun Qingwen, Guizhou University of Traditional Chinese Medicine. Benzene datatum is purchased from Beijing Sun Pharmaceutical Co., Ltd. Bifendatatum were purchased from Beijing Taiyang Pharmaceutical Co. LTD. Alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), acetaldehyde dehydrogenase (ALDH) and alcohol dehydrogenase (ADH) kits were acquired from Shanghai enzyme linked Biotechnology Co., Ltd. (Shanghai, China). High performance liquid chromatography grade methanol and acetonitrile were purchased from TEDIA company (Fairfield, CA, USA). Mass-grade formic acid was purchased from Roy Science Inc. (Charlotte, NC, USA). Ultrapure water was prepared using Millipore milliq purification system (Bedford, MA, USA), and all other chemicals were analytical.

Chen H., Peng L., Zhao C., Cai Z, & Zhou X. (2022). Protective Mechanism of Polygonum perfoliatum L. Extract on Chronic Alcoholic Liver Injury Based on UHPLC-QExactive Plus Mass Spectrometry Lipidomics and MALDI-TOF/TOF Mass Spectrometry Imaging. Foods, 11(11), 1583.

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Metabolite Derivatization for GC-MS Analysis

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BSTFA+1% TMCS (N, O-bis (trimethylsilyl) trifluoroacetamide with 1% trimethylchlorosilane), methoxyamine hydrochloride and pyridine, internal standard cis-10-nonadecenoic acid (C19:1, >99% purity), and the other 21 chemical standards of metabolites (shown in Table 2) were purchased from Sigma-Aldrich (Saint Louis, MO, USA). High-performance liquid chromatography grade methanol was purchased from Tedia Co., Inc. (Fairfield, USA).

Feng D., Xia Z., Zhou J., Lu H., Zhang C., Fan R., Xiong X., Cui H., Gan P., Huang W., Peng W., He F., Wang Z., Wang Y, & Tang T. (2017). Metabolomics reveals the effect of Xuefu Zhuyu Decoction on plasma metabolism in rats with acute traumatic brain injury. Oncotarget, 8(55), 94692-94710.

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