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Female nod scid γc nsg mice

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Female NOD-SCID-γc−/− (NSG) mice are a genetically engineered mouse model. They lack mature T cells, B cells, and natural killer cells, making them highly immunodeficient.

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NOD-SCID-γc−/− (NSG) mice NOD/SCID/γc−/− (NSG) NSG (NOD-SCID) mice Female NOD/SCID mice Female NSG mice NOD/SCID mice Female SCID mice Female NOD mice NOD/SCID NSG mice

3 protocols using female nod scid γc nsg mice

1

Adoptive Cell Therapy for Leukemia

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Female NOD-SCID-γc−/− (NSG) mice (6 to 8 weeks old) were purchased from the Jackson laboratory and housed at the Baylor College of Medicine Animal Facility. Sublethally irradiated (120 cGy) mice were infused intravenously (tail vein) with 3 × 106 BV173.ffluc cells per mouse 4 to 6 hours later. Leukemia burden was monitored by bioluminescence imaging (BLI) (photons/second/cm2/sr) using the Xenogen in vivo imaging system (IVIS) (Caliper Life Sciences). Three T cell infusions (5 × 106 transgenic cells or controls per mouse, every 2 to 3 days) were administered intravenously (tail vein or retro-orbital) beginning 24 hours after tumor injection. Leukemia growth was monitored weekly by BLI.
Rath J.A., Bajwa G., Carreres B., Hoyer E., Gruber I., Martínez-Paniagua M.A., Yu Y.R., Nouraee N., Sadeghi F., Wu M., Wang T., Hebeisen M., Rufer N., Varadarajan N., Ho P.C., Brenner M.K., Gfeller D, & Arber C. (2020). Single-cell transcriptomics identifies multiple pathways underlying antitumor function of TCR- and CD8αβ-engineered human CD4+ T cells. Science Advances, 6(27), eaaz7809.
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2

Adoptive Transfer of VST for Leukemia

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Female NOD-SCID-γc−/− (NSG) mice (6 to 8 weeks old) were purchased from the Jackson Laboratory and housed at the Baylor College of Medicine Animal Facility. Mice were irradiated with 120 cGy and infused with 3×106 BV173.ffLuc cells/mouse through the tail vein 4 to 6 hours later. Leukemia burden was monitored by bioluminescent imaging (BLI) (photons/s/cm2/sr) using the Xenogen in vivo imaging system (Caliper Life Sciences). Two VST injections (2×106/mouse, 3 days apart) were administered through the tail vein or the retro-orbital vein plexus beginning 24 hours after tumor injection. Leukemia growth was monitored weekly by BLI and survival recorded.
Bajwa G., Lanz I., Cardenas M., Brenner M.K, & Arber C. (2020). Transgenic CD8αβ co-receptor rescues endogenous TCR function in TCR-transgenic virus-specific T cells. Journal for Immunotherapy of Cancer, 8(2), e001487.
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3

Engrafting Murine and Primate Models

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Female NOD/SCID/γc−/− (NSG) mice were purchased from The Jackson Laboratory (Bar Harbor, ME), and housed in a specific pathogen-free facility in micro-isolator cages. Mice were used at 8-12 weeks. Mouse protocols were approved by IACUC at the University of Minnesota. This study used specific pathogen-free, juvenile rhesus macaques (4.6 to 10.4 years of age) that were housed at the Yerkes National Primate Research Center and the Washington National Primate Research Center. All animals were treated in accordance with IACUC regulations.
Hippen K.L., Watkins B., Tkachev V., Lemire A.M., Lehnen C., Riddle M.J., Singh K., Panoskaltsis-Mortari A., Vanhove B., Tolar J., Kean L.S, & Blazar B.R. (2016). Preclinical testing of anti-human CD28 Fab’ antibody in a novel nonhuman primate (NHP) small animal rodent model of xenogenic graft-versus-host disease (GVHD). Transplantation, 100(12), 2630-2639.
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