B6 cg tg itgax cre 1 1reiz j mice

Manufactured by Jackson ImmunoResearch

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B6.Cg-Tg(Itgax-cre)1-1Reiz/J mice are a transgenic mouse strain that expresses Cre recombinase under the control of the Itgax (CD11c) promoter. The Itgax gene encodes the integrin alpha X (CD11c) protein, which is expressed on the surface of dendritic cells and some macrophage populations. This strain can be used to study the role of dendritic cells in various biological processes.

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Lab products found in correlation

Cd11c cre, by Jackson ImmunoResearch (1 mentions) C57bl 6j mice, by Jackson ImmunoResearch (1 mentions) B6.129 hif1atm3rsjo j mice, by Jackson ImmunoResearch (1 mentions) C57bl 6j, by Jackson ImmunoResearch (1 mentions)

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B6.Cg-Tg(Itgax-cre)1-1Reiz/J (8 citations) Itgax-Cre (4 citations) Itgax-Cre mice (3 citations) Itgax-cre-Tg (2 citations) B6.Cg-Tg(Itgax-cre)1-1Reiz/J (CD11c-Cre) mice (2 citations)

3 protocols using b6 cg tg itgax cre 1 1reiz j mice

Generation and Use of E2-2 Knockout Mice

Cited 1 time

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C57BL/6 (B6) male mice were purchased from Taconic (Ejby, Denmark). IFNAR^−/− mice were kindly provided by B. Johansson-Lindbom, Lund University (Lund, Sweden). B6.E2-2^fl/fl mice were generated as previously detailed [23 (link)] and B6.Cg-Tg(Itgax-cre)1-1Reiz/J mice were purchased from Jackson Laboratory (Bar Harbor, ME, USA). B6.E2-2^fl/fl and B6.Cg-Tg(Itgax-cre)1-1Reiz/J mice were paired; the offspring were screened for flox-sites and cre-recombinase and were bred to produce the B6.E2-2^fl/flItgax.cre⁺ and B6.E2-2^fl/flItgax.cre⁻ mice used in this study.
B6.E2-2^fl/flItgax.cre mice were bred in a specific pathogen-free animal facility at Lund University and kept under standard conditions with ad libitum access to water and food during experiments. The experiments were conducted in compliance with the National Institutes of Health guidelines, and all animal experimental procedures were approved by the ethical committee of Lund University Animal Care and Use.

Hannibal T.D., Schmidt-Christensen A., Nilsson J., Fransén-Pettersson N., Hansen L, & Holmberg D. (2017). Deficiency in plasmacytoid dendritic cells and type I interferon signalling prevents diet-induced obesity and insulin resistance in mice. Diabetologia, 60(10), 2033-2041.

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Conditional Knockout of Stat3 in CD11c+ Cells

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C57BL/6J mice were acquired from The Jackson Laboratory. B6.Cg-Tg (Itgax-cre)1-1Reiz/J mice (CD11c-Cre; 008068; The Jackson Laboratory) were bred with Stat3^f/f mice (Caton et al., 2007 (link); Takeda et al., 1998 (link)) to generate CD11c-Cre⁺Stat3^f/f mice (Stat3^Δ/Δ) and Cre-negative Stat3^f/f littermate controls (termed herein, Stat3^+/+). All mice were maintained in a specific pathogen–free animal facility at MD Anderson Cancer Center. Mice of both sexes were analyzed, ranging in age from 7 through 13 wk. Age- and sex-matched littermates were chosen randomly for inclusion in treatment groups and were used in accordance with MD Anderson Cancer Center Institutional Animal Care and Use Committee–approved protocols.

Zhou Y., Medik Y.B., Patel B., Zamler D.B., Chen S., Chapman T., Schneider S., Park E.M., Babcock R.L., Chrisikos T.T., Kahn L.M., Dyevoich A.M., Pineda J.E., Wong M.C., Mishra A.K., Cass S.H., Cogdill A.P., Johnson D.H., Johnson S.B., Wani K., Ledesma D.A., Hudgens C.W., Wang J., Wadud Khan M.A., Peterson C.B., Joon A.Y., Peng W., Li H.S., Arora R., Tang X., Raso M.G., Zhang X., Foo W.C., Tetzlaff M.T., Diehl G.E., Clise-Dwyer K., Whitley E.M., Gubin M.M., Allison J.P., Hwu P., Ajami N.J., Diab A., Wargo J.A, & Watowich S.S. (2022). Intestinal toxicity to CTLA-4 blockade driven by IL-6 and myeloid infiltration. The Journal of Experimental Medicine, 220(2), e20221333.

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Genetically Modified Mice for EAE

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Adult female mice were used on a C57Bl/6J background (The Jackson Laboratory, 000664), except for HIF-1α reporter FVB.129S6-Gt(ROSA)26Sortm2(HIF1A/luc)Kael/J mice (The Jackson Laboratory, 006206). B6.Cg-Tg(Itgax-cre)1–1Reiz/J mice (The Jackson Laboratory, 008068) were bred with B6.129-Hif1a^tm3Rsjo/J mice (The Jackson Laboratory, 007561) to generate Itgax^CreHIF-1α^fl mice. Itgax^CreXBP1^fl mice^{26 (link)} were a gift from J. R. Cubillos Ruiz and L. Glimcher. C57BL/6-Tg(Tcra2D2, Tcrb2D2)1Kuch/J mice^{51 (link)} (The Jackson Laboratory, 006912) were used for co-co-culture with DCs. All mice were housed in sterile autoclaved cages with irradiated food and acidified, autoclaved water. Mouse handling and weekly cage changes were performed by staff wearing sterile gowns, masks and gloves in a sterile biosafety hood. All mice were kept in a specific-pathogen-free facility at the Hale Building of Transformative Medicine at the Brigham and Women’s Hospital. All mice were 8–10 weeks old at the time of EAE induction. All procedures were reviewed and approved under the guidelines of the Institutional Animal Care and Use Committee (IACUC) at Brigham and Women’s Hospital.

Zhu Y., Traub L.M, & Kornfeld S. (1999). High-Affinity Binding Of The AP-1 Adaptor Complex to Trans-Golgi Network Membranes Devoid Of Mannose 6-Phosphate Receptors. Molecular Biology of the Cell, 10(3), 537-549.

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