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Minocycline hydrochloride

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Minocycline hydrochloride is a chemical compound that is used as a laboratory reagent. It is a member of the tetracycline class of antibiotics. Minocycline hydrochloride is often used in research applications, but its core function is as a chemical agent without further interpretation on its intended use.

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Lab products found in correlation

D 2 amino 5 phosphonopentanoic acid ap 5, by Merck Group (1 mentions) M tuberculosis h37ra, by BD (1 mentions) Apocynin, by Bio-Techne (1 mentions) Incomplete freund s adjuvant, by Merck Group (1 mentions) Il 1β, by R&D Systems (1 mentions)

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Minocycline (3 citations)

2 protocols using minocycline hydrochloride

1

Analyzing Neuroprotective Compounds

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The chemicals and drugs used in this study were as follows: D-(-)-2-amino-5-phosphonopentanoic acid (AP5) was purchased from Sigma (St. Louis). (RS)-2-Amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl) propanoic acid (ATPA) and minocycline hydrochloride were purchased from Tocris Cookson (Bristol, UK). Drugs were prepared as stock solutions for frozen aliquots at -20°C. All these drugs were diluted from the stock solution to the final desired concentration in the artificial cerebrospinal fluid (ACSF) before immediate use.
Song Q., Liu M.G, & Zhuo M. (2015). Minocycline does not affect long-term potentiation in the anterior cingulate cortex of normal adult mice. Molecular Pain, 11, 25.
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2

Freund's Adjuvant-Induced Inflammation

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Freund’s incomplete adjuvant was purchased from Sigma-Aldrich (Milan, Italy); desiccated mycobacteria, M. tuberculosis H37Ra and M. butyricum, were from Difco laboratories (Detroit, U.S.A.); minocycline hydrochloride and apocynin were from Tocris Bioscience (Bristol, U.K.); IL-1β (60 pg/ml) was from R&D Systems (Minneapolis, U.S.A.).
Di Filippo M., de Iure A., Giampà C., Chiasserini D., Tozzi A., Orvietani P.L., Ghiglieri V., Tantucci M., Durante V., Quiroga-Varela A., Mancini A., Costa C., Sarchielli P., Fusco F.R, & Calabresi P. (2016). Persistent activation of microglia and NADPH drive hippocampal dysfunction in experimental multiple sclerosis. Scientific Reports, 6, 20926.
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